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This resulted in an opnion-based rather than evidence-based position statement. Following suggestions were made on how to treat couples who are distressed by SDD (i) normalize and depathologize variation in sexual desire; (ii) educate about the natural course of sexual desire; (iii) emphasize the dyadic, age-related, and relative nature of SDD; (iv) challenge the myth of spontaneous sexual desire; (v) promote open sexual communication; (vi) assist in developing joint sexual scripts that are mutually satisfying in addition to search for personal sexual needs; (vii) deal with relationship issues and unmet relationship needs; and (viii) stimulate self-differentiation. CONCLUSION More research is needed on the conceptualization and underlying mechanisms of SDD to develop clinical guidelines to treat couples with SDD. Marieke D, Joana G, Giovanni C, et al. Sexual Desire Discrepancy A Position Statement of the European Society for Sexual Medicine. J Sex Med 2020;XXXXX-XXX. Targeting the transmissible stages of the Plasmodium parasite that develop in the human and mosquito host is a crucial strategy for malaria control and elimination. Medicinal plants offer a prolific source for the discovery of new antimalarial compounds. The recent identification of the gametocytocidal activity of lophirone E, obtained from the African plant Lophira lanceolata (Ochnaceae), inspired the evaluation of the plant also against early sporogonic stages of the parasite development. The bioassay-guided phytochemical study led to the isolation of two known lanceolins and of a new glycosylated bichalcone, named glucolophirone C. Its stereostructure, including absolute configuration of the bichalcone moiety, was elucidated by means of NMR, HRMS, ECD and computational calculations. Lanceolin B proved to be a potent inhibitor of the development of Plasmodium early sporogonic stages indicating that the plant produces two different stage-specific antimalarial agents acting on transmissible stages in the human and mosquito host. This work presents examples of non-sterile mixed culture fermentation of food waste with a cultivated indigenous consortium (IC) gained from food waste, which produces lactic and acetic acids, combined with Saccharomyces cerevisiae, which produces ethanol. All results are flanked by microbial analysis to monitor changes in microbial community. At pH 6 and inoculated with yeast or IC, or both mixed sugars conversion was equal to 71%, 51%, or 67%, respectively. Under pH unregulated conditions metabolic yields were 71%, 67%, or up to 81%. While final titer of acetic acid was not affected by pH (100-200 mM), ethanol and lactic acid titers were. Using mixed culture and pH 6, sugars were almost equally used for formation of ethanol and lactic acid (400-500 mM). However, under pH unregulated conditions 80% of the substrate was converted into ethanol (900-1000 mM). A novel partial nitrification-Anammox biofilm reactor (PNABR) operated under high dissolved oxygen (DO) with pre-anoxic - aerobic - anoxic operational mode was developed for efficient denitrogenation from mature landfill leachate. With DO concentration gradually increasing to 4.03 ± 0.03 mg/L, the ammonia oxidation rate (AOR) was enhanced to 25.8 mgNH4+-N/(L h), while nitrite oxidation bacteria (NOB) was inhibited effectively by alternating free ammonia (FA) and oxygen starvation. DO micro-distribution revealed that estimated 1900 μm of aerobic biofilm could protect anammox biofilm underneath from being inhibited by high DO. qPCR analysis further suggested that ammonia oxidation bacteria (AOB) abundance in whole biofilm was 6.12 × 109 gene copies/(g dry sludge), which was twice than found in the floc. Anammox bacteria accounted for 2.39% of total bacteria in whole biofilm, contributing 90.0% to nitrogen removal. Nitrogen removal rate (NRR) and nitrogen removal efficiency (NRE) finally reached 396.6 gN/(m3 d) and 96.1%, respectively. Aerobic granular sludge (AGS) technology is increasingly considered for wastewater treatment. AGS stability particularly under lower COD/N ratios is an impediment for AGS technology. This study evaluated AGS stability and nitrogen removal at different loading rates of 0.03 to 4 kg NH4+-N m-3 d-1 and COD/N ratios of 18.3 to 0.13. Ammoniacal and total nitrogen removals were high at 99.9% and 99.3%, respectively, during 440 days. Zelavespib MiSeq sequencing revealed a reduction in bacterial diversity and enrichment of ammonia oxidizing bacteria (AOB), anammox and denitrifying bacteria. Quantitative PCR showed enrichment of AOB, anammox bacteria, Nitrospira and denitrifiers. Chemical data and bacterial community supported occurrence of nitritation and anammox pathways. AGS had stable granular structure with excellent settling properties at lower COD/N ≤ 1. Removal of high-strength ammonium could be partly explained by the existing nitrogen pathways suggesting novel mechanisms. Nevertheless, results presented here support implementation of AGS process for ammonium wastewaters. A biorefinery approach was implemented to produce a superantixoident, i.e., astaxanthin, and biofuels, i.e., ethanol and biogas, from the biomass of microalga Haematococcus pluvialis. The hydrolysis of residual biomass obtained from astaxanthin extraction was conducted using α-amylase and glucoamylase for hydrolysis of α-glucans and a mixture of cellulases for β-glucan hydrolysis. Four different hyudrolysis processes were employed and the efficiency of 97.2% over the total residual glucan was obtained, which was then fermented to produce 0.21 g ethanol/g residual biomass. The residuals obtained from astaxanthin extraction and fermentation were anaerobically digested to produce biomethane. The yield of biomethane was 264.8 ml/g volatile solids, 2.9 fold greater than methane yield from raw microalgal biomass. Overall, the process of astaxanthin extraction and consecutive production of ethanol and biogas from H. pluvialis biomass was recognized as a promising process to produce 45.8 g astaxanthin and 7095.3 KJ energy per Kg of raw biomass. This study assessed the effect of different swine manure (SM)/corn stover (CS) mixtures based on total solids (TS) content with respect to hygienization, microbial community dynamics and methane yields on batch anaerobic co-digestion performance. Different ratios of SM and CS with TS content between 0.69 and 6% digested at 75 d revealed SM had the greatest methane yield at 403.9 mL g-1 volatile solids added (VS) and 86.31% VS reduction. BIOLOG AN microplates and lignocellulolytic enzyme assays proved to be rapid tools for characterizing microbial community metabolism as noted by the different carbon source utilization patterns between TS loadings. Hygienization of fecal indicator bacteria groups was achieved with some (E. coli) but not all groups (Clostridia spp.). The results showed that colorimetric biochemical assays and culture-based techniques can rapidly assess microbial community dynamics during co-digestion, and that TS- in the form of lignocellulosic biomass- influences microbial metabolic activities.