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al adaptation and patients quality of life.The article presents the results of the development and testing of the latest, supplemented and modified version of the author's psychodiagnostic technique "Test-questionnaire of propensity adventurousness (AVANT-1)". Adventurousness is viewed as a personality trait, as a stable propensity to adventurous behavior, which is characterized by the internal, mental activity of a person (attitudes, expectations, emotional experiences, thoughts, thought-forms, etc.). This mental activity (energy) induces the person to the corresponding external, physical activity, which manifests itself in adventurous actions, behavior, deeds. The theoretical construct of the latest version of the technique (AVANT-7) is given and described; it diagnoses 7 components of adventurousness, reflecting, mainly, the qualitative level of its continuum and hierarchical structure attitudinal, emotional, cognitive, conative (behavioral) components of adventurousness; sensitivity to one's own and other' adventurous intentions, actions, behavior; integral (general) indicator of adventurousness. The results of approbation of this psychodiagnostic tool, which was carried out according to all the requirements of psychometrics, are analyzed. The theoretical construct of the method was empirically verified, its reliability and validity were proved. The practical area of the technique application is individual and group psychological, psychotherapeutic and psychocorrectional work. The technique allows to measure and describe an individual's propensity to adventurousness, moreover, a personal propensity, which has not been studied by other psychodiagnostic methods, but which manifests itself both in persons with a mental norm and in persons with behavioral, psychological and psychosocial problems up to the transition to character accentuations, to psychopathies and psychopathology.The state of bone mineral density has not been properly examined yet in patients with systemic lupus erythematosus (SLE) and the pathogenetically associated syntropic comorbid lesions of organs and systems. In a randomized manner, after stratification by the presence of SLE, we enrolled 123 premenopausal women aged 21 to 51 years into the study. Patients with SLE, depending on the diagnosed pathogenetically associated syntropic comorbid lesions of organs and systems, were stratified into twenty groups (with hemorrhagic vasculitis, capillaritis, Raynaud syndrome, atherosclerosis, livedo reticularis, venous thrombosis, myocarditis, secondary hypertension, stable angina, pneumonitis, pneumosclerosis, autoimmune hepatitis, steatohepatitis, chronic pancreatitis, aseptic bone necrosis, arthralgia, myalgia, autoimmune thyroiditis, obesity, and alopecia). The bone mineral density (BMD) was determined for patients in each group through dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine and proximal femurwas in the group with stable angina; e) there were no cases of osteoporosis in groups with syntropic venous thrombosis and stable angina, and the largest proportion of osteoporosis cases was in the groups with syntropic autoimmune hepatitis; the prevalence of osteoporosis is significantly higher than the prevalence of normal BMD and the first degree osteopenia in patients with atherosclerosis and chronic pancreatitis; the prevalence of osteoporosis is also significantly higher that the prevalence of normal BMD and all degrees of osteopenia in patients with autoimmune hepatitis.The COVID-19 pandemia has shown that there is not enough knowledge today to fully control it. Along with severe respiratory syndrome, attention has recently been paid to extrapulmonary lesions, including endocrinopathies. The aim of the study was to summarize the current literature data about the effects of the SARS-CoV-2 coronavirus on the thyroid gland. One of the most striking manifestations of viral aggression is de Quervain's subacute thyroiditis. The analysis of works from the most authoritative international abstract bibliographic databases was carried out using methods of analysis and processing of scientific resources. Based on the analysis, it was concluded that subacute thyroiditis can be both a clinical manifestation and a complication of COVID-19. The SARS-CoV-2 coronavirus can also trigger other thyroid diseases. The causes of subacute thyroiditis are considered to be the direct effect of the SARS-CoV-2 coronavirus on thyroid cells due to the use of ACE2 receptors, the subsequent inflammatory reaction and apoptosis, as well as central hypothalamus-pituitary mechanisms. The clinical variants of subacute thyroiditis in COVID-19 are diverse and have not been fully evaluated. click here In this regard, it can be concluded that the true incidence of subacute thyroiditis in COVID-19 is much greater, since it is masked by severe lesions of other organs.It has been established that the eosinophilic phenotype of COPD is separate phenotype of the disease. The results of some studies demonstrate the possibility that may presence a phenotype with an increased level of eosinophil activity. To study the relationship between the blood ECP level and the characteristics of the course of COPD, we examined 161 patients with COPD aged from 40 to 70 years old, smoking index> 10 pack-years, no history of atopy, total blood Ig E 100 cells/μL in combination with ≥2 exacerbations of moderate or severe severity during the year, but not with stratification by the level of blood eosinophils (≥300 cells/μL, less then 300 cells/μL). It has been shown that an increase in ECP in accordance with moderate and severe exacerbations is a more reliable markers of the development of the eosinophilic phenotype in patients with COPD.The purpose of the study was to search for a correlation between FEV1 and the possible predictors that determine disease progression and lung function deterioration in COPD patients. The research was conducted at N. Kipshidze Central University Clinic. 78 COPD patients participated in it. Spirometry was used to diagnose the participants and GOLD guidelines for COPD were applied to estimate stages of disease severity. Multiple regression analysis were conducted in order to estimate severity of COPD and its risk factors. The research revealed statistically significant correlation between lung function deterioration and the factors such as age, BMI, duration of COPD, hospitalization frequency due to COPD exacerbation based on the patient's anamnesis and self-assessment questionnaire for dyspnea. It can be considered statistically significant that early diagnosing of COPD and therefore timely and adequate treatment, prevention of disease exacerbation and adherence to a healthy lifestyle notably determines severity of the disease and its prognosis.