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1 ± 1.3 to 4.9 ± 2.5 (p < 0.001) and from 3.3 ± 2.5; (p 0.021), respectively, and their risk of hospital admission (RR 0.68 95% CI [0.56, 0.82]) and of secondary failure (0.16 95% CI 95% [0 , 07; 0.38]) decreased. Only one adverse event (tachycardia) was recorded.

The administration of a single dose of magnesium sulfate proved to be more effective and safe than the use of aminophylline as a second- line drug.

The administration of a single dose of magnesium sulfate proved to be more effective and safe than the use of aminophylline as a second- line drug.

Prader-Willi Syndrome (PWS) is the most common cause of genetic obesity. Hyperphagia and obe sity are the most associated concepts with this condition. However, undernutrition secondary to severe hypotonia and feeding difficulties is the predominant initial feature.

to reprodu ce and communicate the nutritional phases on a series of Chilean cases with PWS.

Cross-sectional study in which clinical records of PWS individuals under nutritional con trol at the Clínica Santa María in Santiago, Chile between 2017 and 2018 were analyzed. The anthro pometric references of the World Health Organization were used to carry out the nutritional as sessment. The classification into nutritional phases was according to the Miller criteria.

24 patients from infants to adults were included. All children aged under 9 months were in phase I and had malnutrition or were eutrophic; those between 9 and 25 months were classified in phase 2a; pa tients between 2.1 and 4.5 years were distributed between phases 1 and 2 and 66% were eutrophic; those between 4.5 to 8 years, 80% were in phase 2a and 2b and obesity begins to appear, and patients over 8 years of age, 75% were in phase 3 and all are overweight or obese. There was an association bet ween nutritional phase and age but not between it and nutritional status.

In our series, the nutritional phases described according to age were reproduced according to those internationally described. There was no association between nutritional status and age.

In our series, the nutritional phases described according to age were reproduced according to those internationally described. There was no association between nutritional status and age.

Multiplex polymerase chain reaction (PCR) allows simultaneous detection of respiratory viruses, raising questions about their relevance in the clinical feature.

To evaluate the contribution of clinical, epidemiological, and virological factors in the clinical course of children hospitalized due to ARI with viral co-detection.

Pediatric patients ≤ 15 years old, hospitalized due to ARI at the UC-CHRISTUS Health Network Clinical Hospital between June and October 2014, and who presented a positive respiratory molecular panel test, were included. Respiratory samples (nasopharyngeal swab, tracheal aspiration, or bronchoalveolar lavage) with positive panel tests by Seeplex® RV15 OneStep ACE Detection Seegene® technique, were analyzed with a second technique (xTAG-RVP-FASTv2 Luminex®, USA), which allows simultaneous and semi-quantitative detection of 17 respiratory viruses. Clinical and epidemiological records were collected.

One virus was identified in 42/57 children (74%) and two or more in 15/57 (26%). Intospitalized pediatric patients.

In children hospitalized due to ARI, viral co-detection is frequent and associated with more ICU hospitalizations. Our study highlights the presence of HRV/ EV in viral co-detection and longer length of stay. More studies are needed to define the relevance of viral co-detection in hospitalized pediatric patients.Psychosomatic medicine explores the psychological, behavioral, and social elements that influence people's health and quality of life. This discipline develops skills and knowledge used in the evalua tion and management of psychosocial elements interfering in the process of illness and healing. The Child and Adolescent Consultation-Liaison Psychiatry (CACLP) is a discipline that has been empi rically installed in order to favor adherence to treatments and recovery of children and teenagers du ring the process of illness. There is a need for developing this discipline in Chile, but so far there are limited national and international records and literature dedicated to it. The objective of this article is to update the concepts of structure and describe how a CACLP unit in a high complexity teaching hospital works in general, discussing the clinical challenges involved in these issues.

Despite numerous experimental studies presenting laparoscopic treatment of inguinal hernia in a pig model so far no described technique has been used in clinical patients of this species. Minimal invasiveness and the simplicity of closure of the inguinal canal using the Percutaneous Internal Ring Suturing (PIRS) technique makes it the world's first technique for laparoscopic treatment of inguinal hernia in pigs as clinical patients.

This study aims to assess the applicability and effectiveness of the laparoscopic PIRS technique in the treatment of inguinal hernia in pigs as clinical patients and to compare the PIRS technique with the open surgery technique, which is currently being used.

The study was conducted on 22 non-castrated male pigs with inguinal hernia (clinical patients), divided into two equal groups PIRS and open surgery (OS). In the PIRS group, the inner inguinal ring was closed with an optical trocar inserted at the umbilicus level and an injection needle with a suture material inserted peed as an alternative to the open technique in the treatment of inguinal hernias in pigs not subjected to surgical castration.

The effectiveness of the PIRS technique is comparable to that of open surgery. L-Kynurenine datasheet Considering the simplicity of the PIRS procedure and its minimal invasiveness, this technique may be used as an alternative to the open technique in the treatment of inguinal hernias in pigs not subjected to surgical castration.

Aortic stiffness is associated with risk of cardiovascular events. Carotid-femoral pulse wave velocity (cfPWV) is the current noninvasive gold standard for assessing aortic stiffness. However, the cfPWV measurement is challenging, requiring simultaneous signals at the carotid and femoral sites.

In this study, the aortic PWV is estimated using a single radial pressure waveform and compared with cfPWV. 111 subjects' aortic PWVs are estimated from the decomposition of the derived central aortic pressure waveform based on three types of reconstructed flow waveform the peak of triangular flow waveform based on 30% ejection time (Q30%tri), the peak of triangular flow waveform based on inflection point (Qtri), and averaged flow waveform (Qavg). The central aortic pressure waveform is derived from a radial pressure waveform via a validated transfer function.

The Qavg is used for estimating aortic PWV without the determination of the peak point of the triangular flow waveforms. The estimated aortic PWV shows good agreement with cfPWV. The mean difference ± SD is 0.29 ± 1.50 m/s (r2 = 0.29, p<0.001) for the Q30%tri; 0.27 ± 1.40 m/s (r2 = 0.38, p<0.001) for the Qtri; 0.23 ± 1.39 m/s (r2 = 0.40, p<0.001) for the Qavg. The correlation between estimated aortic PWV based on Q30%tri and measured cfPWV is weak. The results of Qtri and Qavg show no obvious difference.

The proposed method can be used as a less complex way than conventional measurement of cfPWV to further assess arterial stiffness and predict cardiovascular risks or events.

The proposed method can be used as a less complex way than conventional measurement of cfPWV to further assess arterial stiffness and predict cardiovascular risks or events.Islet transplantation is a promising treatment for Type 1 diabetes. However, treatment failure can result from loss of functional cells associated with cell dispersion, low viability, and severe immune response. To overcome these limitations, various islet encapsulation approaches have been introduced. Among them, macroencapsulation offers the advantages of delivering and retrieving a large volume of islets in one system. In this study, we developed a hybrid encapsulation system composed of a macroporous polymer capsule with stagger-type membrane and assemblable structure, and a nanoporous dECM hydrogel containing pancreatic islet-like aggregates using 3D bioprinting technique. The outer part (macroporous polymer capsule) was designed to have an interconnected porous architecture, which allows insulin-producing β cells encapsulated in the hybrid encapsulation system to maintain their cellular behaviors, including viability, cell proliferation, and insulin-producing function. The inner part (nanoporous dECM hy the clinical outcomes by driving structural maturation and functional improvement of cells.To study the dependence of the relative stability of surface (VA) and subsurface (VB) oxygen vacancies with the crystal facet of CeO2, the reduced (100), (110) and (111) surfaces, with two different concentrations of vacancies, were investigated by means of density functional theory (DFT+U) calculations. The results show that the trend in the near-surface vacancy formation energies for comparable vacancy spacings, i.e. (110) less then (100) less then (111), does not follow the one in the surface stability of the facets, i.e. (111) less then (110) less then (100). The results also reveal that the preference of vacancies for surface or subsurface sites, as well as the preferred location of the associated Ce3+polarons, are facet and concentration-dependent. At the higher vacancy concentration, the VA is more stable than the VBat the (110) facet whereas at the (111), it is the other way around, and at the (100) facet, both the VAand the VBhave similar stability. The stability of the VAvacancies, compared to that of the VB, is accentuated as the concentration decreases. Nearest neighbor polarons to the vacant sites are only observed for the less densely packed (110) and (100) facets. These findings are rationalized in terms of the packing density of the facets, the lattice relaxation effects induced by vacancy formation and the localization of the excess charge, as well as the repulsive Ce3+-Ce3+interactions.Development of nanocomposites as drug delivery vectors is a burgeoning field of research. However, the usage of such newly invented nanomatrices are often limited by the shortcomings associated with the testing of their real-life efficacy. Many drugs fail because a monolayer framework ofin vitrocell line screening method does not adequately mimic thein vivothree-dimensional microenvironments. In this direction, the study unveils the development of a continuous flow microreactor wherein the cellulose acetate nanoparticles (CANPs) with varying sizes are prepared before encapsulating them with an anticancer drug-doxorubicin (DOX). Subsequently, anin vitromicrofluidic drug delivery model has been introduced in which the HeLa cells specific to cervical cancer is treated with the DOX encapsulated CANPs-DOX@CANPs. Thereafter, the transport of the drugs from the fluidic to cellular environment, their transport inside the cell, and the real-time kinetics of the cancer cell apoptosis have been analyzed systematically to uncover the real-time efficacy and cytotoxic effects of the nanocomposite.