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001). There was no difference in the incidence of cPVL (0.8 vs 1.4%, p=0.66). Associations remained significant after adjusting for confounding factors.

A quality improvement bundled approach resulted in a reduction in inotropes use and associated brain morbidities in premature babies.

A quality improvement bundled approach resulted in a reduction in inotropes use and associated brain morbidities in premature babies.

Gallbladder cancer (GBC) represents a wide geographical diversity as well as heterogeneity in clinical and genomic landscape. There seems to be little progress in the development of diagnostic biomarkers, targeted therapies or individualized approaches to GBC management. In this study, we investigated the whole transcriptome profile of GBC patients using RNA sequencing and identified key genes and pathways associated with gallbladder cancer using bioinformatics.

A total of 10 cases of GBC were collected and sequenced. The raw reads of the gallbladder sample was compared with the gallbladder normal control (SRA Database ID ERX288537 HPA RNA-seq normal tissues gallbladder). Using Gene ontology analysis the differentially expressed genes were categorized into the biological pathway, cellular component, and molecular function. Pathway enrichment analyses, protein-protein interaction, transcription factor and miRNA interaction that regulate the expression of hub genes were conducted using bioinformatics tool.

r cancer development.The current study was conducted to investigate the role of sulfur (S) and reduced glutathione (GSH) in mitigating arsenic (As) toxicity in Isatis cappadocica and Erysimum allionii. These plants were exposed for 3 weeks to different concentrations (0, 400 and 800 μM) of As to measure fresh weight, total chlorophyll, proline and hydrogen peroxide (H2O2) content, As and S accumulation, and guaiacol peroxidase (POD) and glutathione S-transferase (GST) along with the supplementation of 20 mg L-1 of S and 500 μM of GSH. Results revealed the significant reduction of fresh weight (especially in E. allionii), activities of POD and GST enzymes and proline content as compare to control. However, the application of S and GSH enhanced the fresh weight. Inhibition in H2O2 accumulation and improvement in antioxidant responses were measured with the application of S and GSH. Hence, the supplementation of S and GSH enhanced fresh weight and total chlorophyll in both I. cappadocica and E. allionii by alleviating the adverse effects of As stress via decreased H2O2 content and restricted As uptake.The role of ionic excretions and hyper-accumulation of salts through alterations of structural and functional traits in five populations of Suaeda vera Forssk. ex J.F. Gmel., a halophytic salt-indicator species of saline environments, was explored. Differently adapted populations of S. vera exhibited specific structural and functional responses for the survival in hyper-saline conditions. Better growth in population from moderately saline habitat (25-30 dS m-1) was linked to high shoot and root K+ and increased ion selectivity (K+/Na+ and Ca2+/Na+). Increased excretion of Na+ and Cl- with increasing salinity level was a critical mechanism in maintaining ionic balance. Drastic differences were observed for anatomical characteristics in populations inhabiting differentially salt-affected lands. The plants from highly saline sites were characterized by narrow metaxylem vessels, low proportion of cortical parenchyma, and reduced phloem area leading to stunted growth. Contrariwise, root area significantly increased due to high proportion of sclerified xylem tissue, which was associated with easier conduction of solutes and protection of roots from collapsing. Root sclerification particularly at the highest salinity regime was a key factor in the survival of this species in salt-affected compact soils. Leaf anatomical characteristics showed reduction with increasing salinity, but the leaf thickness responded otherwise. This contributed to increased leaf succulence because of high proportion of storage parenchyma in populations colonizing hyper-saline habitats. It was concluded that moderate salinity conditions were more suitable for the growth of S. vera, though some populations of this species were able to tolerate much higher salinity levels.Cement is a fundamental building and construction material for societies around the world. However, its manufacturing process is exceptionally energy intensive and has a substantial contribution to the man-made global warming potential which calls for immediate reduction. In this context, the implementation of green production practices and technologies in the Indian cement sector is of particular interest and global impact given that the country is the second biggest producer worldwide. Furthermore, the literature reveals that although the implementation of green practices in the cement manufacturing sector faces barriers across a variety of aspects, there is only limited research focussing on developing countries. This research covers this gap by concentrating on the barriers encountered by the cement sector of India and proposes strategies for their alleviation based on input from five experts and the use of the multi-criteria decision making method (MCDM) best-worst method (BWM). The results show that the lack of conducive corporate environment is the most important barrier, inadequate skills and attitudes are the second, while capital-related limitations come third. The experts highlight the need for mechanisms promoting cost effective environmental research and training as well as appropriate funding instruments and procurement rules from the government. Furthermore, a clear vision and plan from the management's part are fundamental for the effective incorporation of green practices in the organisational identity and the required employee engagement.A systematic understanding of the driving mechanisms of ecosystem services (ESs) and the relationships among them is critical for successful ecosystem management. However, the impact of driving factors on the relationships between ESs and the formation of ecosystem service bundles (ESBs) remains unclear. To address this gap, we developed a modeling process that used random forest (RF) to model the ESs and ESBs of Zhejiang Province, China, in regression and classification mode, respectively, and the Shapley Additive Explanations (SHAP) method to interpret the underlying driving forces. We first mapped the spatial distribution of seven ESs in Zhejiang Province at a 1 × 1 km spatial resolution and then used the K-means clustering algorithm to obtain four ESBs. Combining the RF models with SHAP analysis, the results showed that each ES had key driving factors, and the relationships of synergy and trade-off between ESs were determined by the driving direction and intensity of the key factors. The driving factors affect the relationships of ESs and consequently affect the formation of ESBs. Thus, managing the dominant drivers is key to improving the supply capacity of ESs.Graphitic carbon nitride (g-C3N4) is well recognised as one of the most promising materials for photocatalytic activities such as environmental remediation via organic pollution elimination. New methods of nanoscale structure design introduce tunable electrical characteristics and broaden their use as visible light-induced photocatalysts. This paper summarises the most recent developments in the design of g-C3N4 with element doping. Various methods of introducing metal and nonmetal elements into g-C3N4 have been investigated in order to simultaneously tune the material's textural and electronic properties to improve its response to the entire visible light range, facilitate charge separation, and extend charge carrier lifetime. The degradation of antibiotics is one of the application domains of such doped g-C3N4. We expect that this research will provide fresh insights into clear design methods for efficient photocatalysts that will solve environmental challenges in a sustainable manner. Finally, the problems and potential associated with g-C3N4-based nanomaterials are discussed. This review is expected to encourage the ongoing development of g-C3N4-based materials for greater efficiency in photocatalytic antibiotic degradation.Sand production remains a huge obstacle in many oil and gas fields around the world, but the hazards of contaminants riding on the produced sand are often not emphasised. Improper disposal of the sand could see the toxic leaching into the environment including the food chain, endangering all living organisms. Fimepinostat The impending sand production from an oilfield offshore Sabah also suffers from the lack of hazards identification; hence, this study was conducted to assess the contaminant on the produced sand. Sand samples were collected from multiple wells in the area, with the contaminants extracted using n-hexane and subjected to chemical and thermal analyses. FTIR and GC-MS detected traces of harmful pollutants like naphthalene, amine substances, cyclohexanol, and short-chain alkanes. It was discovered that the volatile fraction of the contaminants was able to evaporate at 33 °C, while high energy was needed to remove 100% of the contaminants from the sand. Overall, the produced sand from the oilfield was unsafe and required treatment before it could be dumped or used.In this study, the adsorptive removal of hexavalent chromium [Cr(VI)] from aqueous solutions by the pristine and salt-treated (CaCl2) erythromycin production residue (EPRs and SEPRs) were investigated. Batch experiments were carried out to determine the effect of contact time, sorbent dosage, pH, initial Cr concentration, and temperature on Cr(VI) sorption by EPRs and SEPRs. The highest adsorptive removal capacities were achieved at the pH equal to 1.0, and the maximum adsorption capacities for EPRs and SEPRs at optimized conditions were 21.74 and 35.24 mg g-1, respectively. The FTIR spectra and SEM studies were examined for the pristine adsorbent and after the adsorption of Cr(VI). Moreover, thermodynamic results indicated that Cr sorption by EPR/SERPs was feasible, spontaneous, and endothermic under the optimum conditions. Langmuir model fitted well with the experimental data. Kinetic modeling revealed that the biosorption of Cr(VI) by EPRs and SEPRs obeyed the second-order model than the first-order model. The process involving rate-controlling step is much complex involving both boundary layer and intra-particle diffusion processes. Furthermore, the adsorption-coupled-reduction process was believed as the main mechanism of Cr(VI) removal by EPRs and SEPRs. In summary, both adsorbents could be considered as promising low-cost biosorbent for the removal of Cr(VI) from aqueous systems.The present study was designed to evaluate in vitro and in vivo the potential anti-inflammatory and nephroprotective potential of ethyl acetate fraction extracted from Fumaria officinalis (EAF) against permethrin (PER). Male wistar rats were treated daily by gavage during 7 days as follows group C negative control rats received 2 mL/kg bw of corn oil, group EAF positive control rats received EAF at a dose of 200 mg/kg bw dissolved in water, group PER rats received PER at a dose of 34.05 mg/kg bw and group (PER + EAF) rats received PER (34.05 mg/kg bw) and EAF (200 mg/kg bw). In vitro study showed the ability of EAF to inhibit protein denaturation and heat-induced hemolysis confirming its anti-inflammatory activity. In vivo, PER treatment decreased calcium (Ca) and phosphorus (P) levels and increased lactate dehydrogenase (LDH) activity in plasma. It induced oxidative stress objectified by an increase in the lipid peroxidation and protein oxidation and a perturbation of antioxidant system in kidney and mitochondria.