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© The Author(s) 2020. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. For permissions, please email journals.permissions@oup.com.OBJECTIVE To describe the implementation of technological support important for optimizing clinical management of the COVID-19 pandemic. MATERIALS AND METHODS Our health system has confirmed prior and current cases of COVID-19. An Incident Command Center was established early in the crisis and helped identify electronic health record (EHR) based tools to support clinical care. RESULTS We outline the design and implementation of EHR based rapid screening processes, laboratory testing, clinical decision support, reporting tools, and patient-facing technology related to COVID-19. DISCUSSION The EHR is a useful tool to enable rapid deployment of standardized processes. UC San Diego Health built multiple COVID-19-specific tools to support outbreak management, including scripted triaging, electronic check-in, standard ordering and documentation, secure messaging, real-time data analytics, and telemedicine capabilities. Challenges included the need to frequently adjust build to meet rapidly evolving requirements, communication and adoption, and coordinating the needs of multiple stakeholders while maintaining high-quality, pre-pandemic medical care. CONCLUSION The EHR is an essential tool in supporting the clinical needs of a health system managing the COVID-19 pandemic. © The Author(s) 2020. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email journals.permissions@oup.com.Understanding the effects of polymer chemistry on membrane ion transport properties is critical for enabling efforts to design advanced highly permselective ion exchange membranes for water purification and energy applications. Here, the effects of fixed charge group type on anion exchange membrane (AEM) apparent permselectivity and ion transport properties were investigated using two crosslinked AEMs. The two AEMs, containing a similar acrylonitrile, styrene and divinyl benzene-based polymer backbone, had either trimethyl ammonium or 1,4-dimethyl imidazolium fixed charge groups. Membrane deswelling, apparent permselectivity and ion transport properties of the two AEMs were characterized using aqueous solutions of lithium chloride, sodium chloride, ammonium chloride, sodium bromide and sodium nitrate. Apparent permselectivity measurements revealed a minor influence of the fixed charge group type on apparent permselectivity. Further analysis of membrane swelling and ion sorption, however, suggests that less hydrophilic fixed charge groups more effectively exclude co-ions compared to more hydrophilic fixed charge groups. Analysis of ion diffusion properties suggest that ion and fixed charge group enthalpy of hydration properties influence ion transport, likely through a counter-ion condensation, ion pairing or binding mechanism. Interactions between fixed charge groups and counter-ions may be stronger if the enthalpy of hydration properties of the ion and fixed charge group are similar, and suppressed counter-ion diffusion was observed in this situation. In general, the hydration properties of the fixed charge group may be important for understanding how fixed charge group chemistry influences ion transport properties in anion exchange membranes.The barrier-improving functions of fermented blueberry pomace (FBP) and its potential mechanism were investigated in this study. Polyphenols and the approximate composition of FBP were evaluated according to the National Standard of the People's Republic of China and the UPLC-MS system. Male C57BL/6 mice were fed a control diet (CD) or a high-fat diet (HFD) with or without FBP supplementation. Oxidative stress, inflammation, histological morphology and the expression of functional proteins in the small intestine of mice were evaluated using the enzyme linked immunosorbent assay (ELISA), quantitative polymerase chain reaction (qPCR) and western blotting. The content of protein, fat, soluble dietary fiber, insoluble dietary fiber and carbohydrates (non-dietary fiber) was 114.5 ± 1.5 g kg-1, 5.0 ± 0.2 g kg-1, 48.0 ± 0.1 g kg-1, 360.3 ± 2.2 g kg-1 and 423 g kg-1 (by difference), respectively. Thirty-six polyphenols were identified in FBP. FBP improved the growth of mice and attenuated hepatic and intestinal oxidative stress. Intestinal inflammation was significantly reduced through the decrease of tumor necrosis factor-alpha (TNF-α) and myeloperoxidase (MPO) as well as an increase of interleukin-10 (IL-10). FBP supplementation significantly improved the intestinal morphology and barrier function, potentially by mediating the NF-κB-MLCK signaling pathway. The supplementation of FBP in HFD mice enhanced the intestinal barrier function. This suggested that polyphenol-rich by-products might provide a similar health effect in HFD individuals.Pesticides, widely used in modern agriculture, could potentially cause environmental pollution and affect human lives. Hence, the development of a highly sensitive sensing element to detect pesticide residues is crucial for food safety and ecosystem protection. Optical methods based on fluorescence properties provide an ideal approach for screening and quantification of these compounds in different medias including water, plant, and nutritional products. see more The development of fluorescence emitting carbon dot-based sensors for monitoring pesticides has attracted great attention in recent years. In comparison to other fluorophores, carbon dots have more promising optical features, higher quantum yields and better biocompatibility. This article aims to present a novel fluorescent sensing method of diazinon, glyphosate, and amicarbazone using plant-based carbon dots. A comprehensive characterization of carbon dots obtained from cauliflower was performed by methods including UV-visible, FTIR spectroscopy, fluorometry, AFM, DLS, and zeta sizer. Following this step, carbon dots were used to detect pesticides. The fluorescence quenching property of carbon dots has been utilized to identify detection limit of 0.25, 0.5, and 2 ng ml-1 for diazinon, amicarbazone, and glyphosate, respectively. Also, real sample study revealed that the detection of pesticides accompanied by our developed nano-sensor is repeatable and accurate. According to carbon dots specificity determination, the prepared nano sensor does not have the potential to identify "bromacil" and "dialen super" pesticides but the other three mentioned pesticides are detectable. The results confirm that synthesized green carbon dots are well qualified for application in food safety and environmental monitoring.