Conradsencalderon6314
To analyze the epidemiology and features of calcaneus osteomyelitis following open reduction and internal fixation (ORIF) after closed calcaneus fracture.
We retrospectively analyzed 127 cases who were diagnosed with calcaneal osteomyelitis following ORIF via the extended lateral "L-shaped" approach after closed calcaneus fracture between March 2016 and August 2019 in our hospital. We analyzed participant demographics including gender, age, body mass index (BMI), trauma mechanism, Sanders classification, co-morbidity, time between initial injury and surgery, operating time, soft tissue stripping tools, tourniquet pressure, bone grafting option, internal fixation option, presence of bleeding after tourniquet deflation, and drainage option.
The majority of cases (n=127) were male (4.5 times more than female gender), at a ratio of 4.471. Falling from height was the main trauma mechanism (79.53%), followed by traffic accident (14.17%), and jumping (6.3%). A total of 51 cases (40.16%) were left-side fractureuet deflation. Drainage tubes were applied in 30 participants (23.62%) while rubber drainage strips in 5 participants (3.94%).
Young males dominated the calcaneus osteomyelitis following traumatic calcaneus fracture cohort in this study. A fall from height was the most frequent trauma mechanism. The presence of severe calcaneus fracture, Sanders type III (48.03%) and type IV (42.52%), were the common fracture types in this population group.
Young males dominated the calcaneus osteomyelitis following traumatic calcaneus fracture cohort in this study. A fall from height was the most frequent trauma mechanism. The presence of severe calcaneus fracture, Sanders type III (48.03%) and type IV (42.52%), were the common fracture types in this population group.
Chronic kidney disease (CKD) is a leading public health problem worldwide. Cardiovascular diseases are the primary cause of death in hemodialysis patients with CKD. FIIN-2 Therefore, it is necessary to develop a simple risk assessment tool for cardiovascular events in hemodialysis patients with CKD.
A cohort of 370 hemodialysis patients, who were recruited between January 2015 to September 2019 in south China, were involved in the present study. On the basis of routine blood test indicators and ultrasonic cardiogram parameters, the optimal parameter set was determined and a Cox proportional hazards model coupled with a nomogram was used to predict cardiovascular risk over 3, 5, and 10 years. Predictive performance was evaluated using Harrell's concordance index (C-index) and the area under the receiver-operating characteristic curve (AUROC). The results were validated using both 10-fold cross-validation and hold-out validation (70% training and 30% validation, repeated 100 times).
The optimal parameter set consisted of hypertension, diabetes mellitus, age, phosphate, triglyceride, C-reactive protein, white blood cells, and interventricular septum thickness. The time-dependent AUROCs for predicting 3-, 5-, and 10-year cardiovascular event occurrence risk were 0.836, 0.845, and 0.869, respectively. The nomogram showed satisfactory prediction performance (C-index 0.808, 95% confidence interval 0.773-0.844) and was well-calibrated. The results were further confirmed by 10-fold cross-validation and hold-out validation (C-index 0.794 and 0.798, respectively).
On the basis of several easy-to-detect clinical parameters, we developed a simple and useful nomogram for predicting cardiovascular risk in long-term hemodialysis patients that is of potential value for clinical application.
On the basis of several easy-to-detect clinical parameters, we developed a simple and useful nomogram for predicting cardiovascular risk in long-term hemodialysis patients that is of potential value for clinical application.
Low-molecular-weight heparin (LMWH) is a part of standard supportive therapy for sepsis, but clinical research on anticoagulant therapy is still controversial. The aim of the present study was to explore the efficacy and safety of LMWH in adult septic patients by meta-analysis.
Information on randomized controlled trials was retrieved from PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and China Wanfang Database from the establishment of each database to February 20, 2020. The therapeutic efficacy indexes of LMWH for adult septic patients were analyzed by Stata15.0 software.
A total of 684 septic patients were included in 10 trials. The results showed that, compared with conventional treatment, LMWH significantly reduced prothrombin time [mean difference (MD) =-0.48, 95% confidence interval (CI) -0.83 to -0.13], Acute Physiology And Chronic Health Evaluation II score (MD=-4.42, 95% CI -5.50 to -3.33), and 28-day mortality [relative risk (RR) =0.52, 95% CI 0.38-0.70], and increased platelet count (MD =34.99, 95% CI 23.37-46.60). LMWH significantly reduced levels of tumor necrosis factor-α, interleukin-6, and D-dimer, and the incidence of multiple organ dysfunction syndrome (MODS), with statistically significant differences. In addition, LMWH did not increase bleeding events (RR =1.29, 95% CI 0.76-2.17).
On the basis of routine treatment, LMWH can improve coagulation function, reduce inflammatory reaction and the risk of bleeding, reduce the incidence of MODS and 28-day mortality rate, and improve the prognosis of adult patients with sepsis.
On the basis of routine treatment, LMWH can improve coagulation function, reduce inflammatory reaction and the risk of bleeding, reduce the incidence of MODS and 28-day mortality rate, and improve the prognosis of adult patients with sepsis.
Postpartum breastfeeding is an effective guarantee for the healthy growth of newborns. Vigorously promoting breastfeeding has substantial benefits for the physical and mental health of mothers and babies, and can also benefit the entire society. The purpose of this study was to explore the effect of multi-dimensional postpartum visits (MDPV) applied to parturients with inverted nipple on improving breastfeeding rates.
A total of 114 parturients with inverted nipples who gave birth in the Drum Tower Hospital Affiliated to Nanjing University School of Medicine from October 2018 to October 2019 and successfully breastfed in the hospital were selected. The patients were divided into two groups according to the random number table method, with 57 cases in each group. The control group received routine postpartum visits, while the observation group received MDPV. Breastfeeding knowledge, rate of exclusive breastfeeding, incidence of maternal mastitis, rate of infant hospitalization, and level of self-efficacy wtfeeding self-efficacy. Thus, it is worthy of promotion.
Vasoactive intestinal peptide (VIP) is an important neurotransmitter involved in the modulation of gastrointestinal function through the stimulation of VIP receptors. However, the expression of VPAC1R, VPAC2R and PAC1R in the human Lower esophageal sphincter (LES) has not been fully clarified. Therefore, the purpose of this study is to explore the expression of these receptors in the human Lower esophageal sphincter, the responses of the Lower esophageal sphincter to Vasoactive intestinal peptide, and the role of Vasoactive intestinal peptide receptors in the responses.
Sling and clasp fiber samples of LES were acquired from patients undergoing subtotal esophagectomy, while circular muscle bundles from the esophagus and gastric fundus were used as control groups. Western blotting and RT-PCR technology were performed to determine the expression of the three VIP receptor subtypes. The isometric tension responses of the muscle sample strips to Ro25-1553 and PG99-465, and the effect of electrical field stimulst Ro25-1553 and EFS could be inhibited by the selective VPAC2 receptor antagonist PG99-465. VPAC2R may be important for the generation of relaxation and functional regulation of the LES.
China is a country with frequent earthquakes. Beichuan was the epicenter of what was later called the Wenchuan earthquake, which caused nearly 80% of the houses in the area to collapse, with 8,605 people killed and 9,693 people missing. The aim of our study was to explore the prevalence of post-traumatic stress disorder (PTSD) and its influence on health-related quality of life (HRQOL) among the survivors 10 years after the 2008 Wenchuan earthquake in China.
A total of 610 survivors from Leigu town in Beichuan County were investigated by a systematic sampling method. Post-traumatic status, HRQOL, and demographic sources were measured by the PTSD Checklist Civilian Version (PCL-C), 36-item Health Survey Short Form (SF-36), and self-questionnaire, respectively.
Ten years after the Wenchuan earthquake, the prevalence of PTSD for survivors was 1.6%. There were significant negative correlations between survivors' SF-36 scores and the scores of PCL-C. Higher scores in post-traumatic status were associated with a higher rate of poor physical HRQOL, which was lower than the mean score [adjusted odds ratio (OR) 1/4 0.96 per SD increase, P 1/4 0.001] and mental HRQOL (adjusted OR 1/4 0.93 per SD increase, P 1/4 0.001). The independent contribution of post-traumatic status to the risk for poor physical and mental HRQOL was 4.9% and 18.7% respectively.
As time has elapsed, the incidence of PTSD has gradually declined after the Wenchuan earthquake. Post-traumatic status was found to influence the health related quality of life of survivors.
As time has elapsed, the incidence of PTSD has gradually declined after the Wenchuan earthquake. Post-traumatic status was found to influence the health related quality of life of survivors.
This study aimed to estimate peripheral blood lymphocyte subsets and programmed death receptor-1 positive (PD-1+) proportions of T cells, and their impact on progression free survival (PFS) and radiological response in lung cancer.
From May 2018 to April 2020, 34patients of the Henan Tumor Hospital who were diagnosed with advanced lung cancer were recruited to this study. Peripheral blood lymphocyte subsets and PD-1+ proportions of T cells were assessed by flow cytometry before and after treatment with immune checkpoint inhibitors (ICIs). The associations among these parameters, and PFS and clinical response were estimated by survival analysis and Fishers' exact test, respectively.
Several lymphocyte variables and biomarkers were found to be correlated with PFS and tumor response, as assessed using the Response Evaluation Criteria in Solid Tumors (RECIST). In all 34 lung cancer participants and a subgroup of 28 participants with non-small cell lung cancer (NSCLC), higher levels of natural killer (NK) cets treated with ICIs combination therapy. In addition, Tregs, as well as the other parameters in lymphocyte subsets, may also predict response.
Our results suggested that the absolute number of NK cells and CD4+/CD8+ cells ratio before treatment could predict longer PFS and better radiological response in lung cancer patients treated with ICIs combination therapy. In addition, Tregs, as well as the other parameters in lymphocyte subsets, may also predict response.
Peritoneal dialysis (PD) is an ideal method for the treatment of chronic kidney disease. Its survival rate and quality of life depend on the quality of dialysis. The quality of dialysis depends on the compliance of patients with drugs and dialysis treatment, the choice of diet, the detection of complications and the monitoring and management of the disease. Therefore, the self-management of PD patients is particularly important. This study explored the role of peer support in improving the self-management ability of PD patients.
A total of 105 PD patients in a Chinese tertiary hospital were enrolled and divided into a control group (35 cases), a WeChat group (intervention group 1; 35 cases), and a face-to-face group (intervention group 2; 35 cases). During the 6-month follow-up, the control group were given individualized education, and the intervention group was given peer support.
After the 6-month intervention, the self-management ability of the intervention group was significantly different from that of the control group (P<0.
