Guerrapersson1246
An analysis of P300 potential in Fz channel with congruent and incongruent flankers revealed no differences in the amplitude of both stimuli in the group of patients with a predominance of negative symptoms, while the amplitude of the evoked response to congruent and incongruent flankers was significantly higher in the group with a predominance of positive symptoms. In the group of patients with a predominance of positive symptoms, an inverse flanker response was established - P300 amplitude was significantly higher upon presentation of an incongruent flanker.
The specific characteristics of evoked responses describing the features of such systems of attention as vigilance, orientation and conflict resolution have been established.
The specific characteristics of evoked responses describing the features of such systems of attention as vigilance, orientation and conflict resolution have been established.
To evaluate the severity of emotional and cognitive disorders, as well as the effectiveness of cognitive-motor training in patients who have undergone spinal cord surgery.
Sixty patients (30 men and 30 women), who were scheduled and subsequently underwent spinal cord surgery, were studied. The patients underwent clinical, somatic and neurological status examinations and quantitative neuropsychological testing. The study was conducted before surgery, a week later, 3 months and 6 months after surgery. The patients were randomly assigned to the main and control groups of 30/30 people by the method of random numbers. The patients did not significantly differ in gender, age and level of education. Patients of the main group, in addition to drug therapy, received cognitive training, which was conducted using the methodological manual «Cognitive training for patients with moderate cognitive disorders» developed by the staff of the Department of Nervous Diseases and Neurosurgery of the A.Ya. Kozhevnikov Clinic oflitation program of patients after spinal neurosurgical operations.
Cognitive and emotional-affective disorders in patients after spinal neurosurgery have a negative impact on the quality of life. The inclusion of cognitive-motor training in the rehabilitation program makes it possible to reduce the severity of cognitive and emotional disorders in the postoperative period and improves the quality of life of patients. The results allow us to recommend the inclusion of cognitive-motor training in the rehabilitation program of patients after spinal neurosurgical operations.
To assess the effectiveness and safety of Erenumab, a monoclonal antibody to calcitonin gene-related peptide receptors, in patients with high-frequency episodic migraine (HFEM) in real-life study.
35 patients with HFEM without aura (≥8-14 attacks per month) (30 females, mean age 32.4±8.1) received monthly subcutaneous administration of Erenumab 70 mg for 3 months. The primary endpoint was the change in monthly migraine days (MMDs) from baseline, the secondary endpoint was the proportion of patients who achieved a 50% reduction in the number of days with headache. The change in pain intensity, change in the number of days of use of acute migraine-specific medication, the effect on daily activity (HIT-6 scale, MIDAS), anxiety and depression (the Hospital Anxiety and Depression Scale) were assessed.
At the end of the third month Erenumab decreased MMDs by 5±3.6 (
=0.00000). A 50% reduction in the mean number of migraine days per month was achieved for 60% of patients, the intensity of headache according tiety and depression, and social maladjustment.
To analyze the results of sphenopalatine ganglion stimulation in treatment of chronic headache.
Medical histories of patients who underwent sphenopalatine ganglion stimulation in 4 clinical centers have been analyzed. The analysis included the type of pain and its characteristics, methods of surgery, CT, MRI, radiography before and after surgery. The follow-up data of patients with implanted pulse generators was collected in an outpatient clinic or by telephone review.
The study included 15 patients with chronic refractory headache, including 14 with cluster headache and one female patient with features of trigeminal autonomic cephalgia without a clear definition of the type of pain. Trial stimulation was performed in 10 patients to determine analgesic effect. Among them stimulation was favorable in 7 cases, and 6 of them underwent pulse generator implantation. In total, 11 (73%) patients underwent implantation with a follow-up from 1 to 60 months. Among them only 6 (54%) patients use stimulation, the remaining 5 (46%) cases had device-related complications (migration, infection of system). Cluster headache has a significant improvement in long-term follow-up.
Sphenopalatine ganglion stimulation may have high potential in the treatment of chronic drug-resistant cluster headache. The complication rate demonstrates that operative technique should be improved.
Sphenopalatine ganglion stimulation may have high potential in the treatment of chronic drug-resistant cluster headache. The complication rate demonstrates that operative technique should be improved.
Evaluation of the safety and effectiveness of the use of a fixed combination of orphenadrine and diclofenac for analgesia in the early postoperative period of cardiac surgery patients.
There were two analgesia regimens evaluated
in a retrospective comparative study. In 23 patients (group 1), Neodolpasse (a fixed combination of 30 mg orphenadrine and 75 mg diclofenac) was administered immediately after trachea extubation. When the severity of pain in VAS increased to more than 50 mm, so 20 mg trimeperidine was administered. In group 2 of 20 patients analgesia in group 2 was performed with patient-controlled analgesia (PCA) with Promedol (trimeperidine) as monotherapy. The intensity of pain was assessed a 100 mm visual-analog scale (VAS) and 5-channel verbal scale (VS) for assessment the severity of the pain syndrome during the patient's moving activity.
A decrease in the severity of the pain syndrome according to VAS from 68.31 to 21.96 mm (
<0.001) was achieved by the first hour after the start ofn the study.
There were demonstrated safety, high analgesic efficacy and significant opioid-sparing effect of a fixed combination of Orphenadrine and Diclofenac in the early postoperative period of cardiac surgery patients within the framework of the inclusion and exclusion criteria accepted in the study.
Is to study and compare models of out-of-hospital psychiatric care in different countries-Italy and England.
Is to study and compare models of out-of-hospital psychiatric care in different countries-Italy and England.In the Italian model of community-based psychiatric care, institutions have been created - homes for permanent residence with a security regime (REMS), the most common of which are intensive (or assertive) treatment in the community and mandatory outpatient treatment. The form of intensive treatment is an active and long-term maintenance and treatment of patients. The essence of the methodology is to provide assistance at home, which is carried out by specially trained multidisciplinary teams, including psychiatrists, nurses, psychologists, social workers. However, in the long term, there is a tendency to increase relapses and acute conditions. The English model of community psychiatric care is based on the practice of the method of «individual case management». Salinosporamide A After the acute attack is stopped, the main work program includes work with a psychologist and/or a psychotherapist in the form of a number of multidimensional group and family therapy activities, training of social skills and ways of independent living, development of communication, self-esteem and confident behavior, which is achieved through psychocorrective work, as well as drug therapy and didactic training on appropriate simulators.Special attention is paid to social recovery, work with the family, social and labor recovery and instrumental support.The manuscript is devoted to the problem of selection of antithrombotic therapy in the management of patients with multifocal atherosclerosis. The leading role of cerebrovascular pathology in the structure of mortality and causes of disability is noted. The questions of etiology and pathogenesis of acute cerebrovascular accident are considered. The pathogenetic subtypes of ischemic stroke and the criteria for their diagnosis were analyzed. The important role of antithrombotic therapy in the prevention of noncardioembolic stroke is presented. Considering the evidence-based medicine data based on the analysis of randomized trials results, modern strategies of antithrombotic therapy were demonstrated. A comparative analysis of the clinical trials results was carried out. New ideas about the benefits of combination therapy with acetylsalicylic acid at a dose of 100 mg/day and with rivaroxaban 2.5 mg twice daily, established in the COMPASS study, are presented.The article provides an overview of scientific publications devoted to the study of the problem of functional cognitive disorders (FCD), which are one of the variants of functional neurological disorders (FND). The authors provide data on the frequency of occurrence of this pathology, the differences between the concepts of FCD and «subjective cognitive disorders» (dissociative (conversion) disorders - F44). The authors show the traditional views on the study of this pathology in the mainstream of hysterical disorders. The modern concepts of information processing disorders as a mechanism of FCD development are considered. Special attention is paid to the role of executive dysfunction in the genesis of FCD. The descriptions of the main clinical manifestations of FCD are given. The basic principles of diagnostic examination of patients with FCD are considered. The article presents modern approaches to the therapy of FCD, with special attention paid to psychotherapeutic correction in this pathology.Patient communication skills are critical for the management of neurological patients, in particular for discussing neurological diagnosis and prognosis. The key communication tools are SPIKES protocol for delivering «bad news» and the Calgary-Cambridge model. These communication tools allow to implement a patient-oriented approach to treatment, build effective communication with the patients, and thus provide them high-quality and personalized medical care.The present review discusses the comorbidity of psychogenic non-epileptic seizures (PNES) with other mental disorders. Data on the prevalence of mood, anxiety, psychotic and personality disorders are presented. The role of traumatic experience in the development of PNES is described. Special attention is given to PNES as an independent nosological entity and its place in the modern classifications of mental disorders.Multiple sclerosis (MS) is a chronic autoimmune disease with a high degree of heterogeneity due to course and prognosis. More than half of MS patients do not discuss their long-term prognosis with the doctor. At the same time, most patients consider the importance of personalized prognosis for decisions in family planning, career, and medical interventions. Clinical markers are used to determine the prognosis in routine clinical practice. However, it is nominally divided into positive and negative factors. It allows making a general conclusion about the MS prognosis. Neuroimaging and biological markers are used mostly for research purposes. But also they are already actively used in clinical trials for endpoint`s investigation. The review describes studies investigating prognostic clinical, neuroimaging, and biological markers.
