Moodycapps8129

Background Non-linguistic cognitive training has been suggested to improve the communication skills of patients with post-stroke aphasia (PSA). However, the association between language and non-linguistic cognitive functions is not fully understood. In this study, we used the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) to evaluate the characteristics of non-linguistic cognitive impairments in Chinese PSA patients. Methods A total of 86 stroke patients were recruited in this study. Language and non-linguistic cognitive impairments were evaluated by the Western Aphasia Battery (WAB) and LOTCA, respectively. The patients were divided into two groups (PSA and non-PSA), and the Chinese norm (the data came from 44 Chinese individuals without neurological disorders in a previous study) was used as the control group. The LOTCA scores were compared among the three groups. Patients in the PSA group were subdivided into the fluent aphasia group (FAG) and the non-FAG according to the Chinese aphasia flu, VP, SP, and MP (r = 0.710, 0.744, 0.565, 0.597, and 0.616; P less then 0.001). Conclusion Compared with stroke patients without aphasia, patients with PSA often have more extensive and serious non-linguistic cognitive impairments. Patients with non-fluent aphasia often present with serious cognitive impairments than those with fluent aphasia, especially the impairments of orientation and SP. Non-linguistic cognitive impairments correlate with language impairments in aphasia.Study Objectives To clarify the effects of sleep duration on stroke and stroke subtypes, we adopted a Mendelian randomization (MR) approach to evaluate their causal relationship. Methods A genome-wide association study including 446,118 participants from UK biobank was used to identify instruments for short sleep, long sleep and sleep duration. Summary-level data for all stroke, ischemic stroke, intracerebral hemorrhage, and their subtypes were obtained from meta-analyses conducted by the MEGASTROKE consortium. MR analyses were performed using the inverse-variance-weighted method, weighted median estimator, MR pleiotropy residual sum and outlier (MR-PRESSO) test, and MR-Egger regression. Sensitivity analyses were further performed using leave-one-out analysis, MR-PRESSO global test and Cochran's Q test to verify the robustness of our findings. Results By two-sample MR, we didn't find causal associations between sleep duration and risk of stroke. However, in the subgroup analysis, we found weak evidence for short sleep in increasing risk of cardio-embolic stroke (odds ratio [OR], 1.33; 95% confidence interval [CI], 1.11-1.60; P = 0.02) and long sleep in increasing risk of large artery stroke [OR, 1.41; 95% CI, 1.02-1.95; P = 0.04]. But the associations were not significant after Bonferroni correction for multiple comparisons. Conclusions Our study suggests that sleep duration is not causally associated with risk of stroke and its subtypes.Increasing evidences indicate that in Myotonic Dystrophy type 1 (DM1 or Steinert disease), an autosomal dominant multisystem disorder caused by a (CTG)n expansion in DMPK gene on chromosome 19q13. 3, is the most common form of inherited muscular dystrophy in adult patients with a global prevalence of 1/8000, and involvement of the central nervous system can be included within the core clinical manifestations of the disease. Variable in its severity and progression rate over time, likely due to the underlying causative molecular mechanisms; this component of the clinical picture presents with high heterogeneity involving cognitive and behavioral alterations, but also sensory-motor neural integration, and in any case, significantly contributing to the disease burden projected to either specific functional neuropsychological domains or quality of life as a whole. JNJ-678 Principle manifestations include alterations of the frontal lobe function, which is more prominent in patients with an early onset, such as in congenitimself a neurologist to better appreciate, evaluate and speculate on this important aspect of Steinert disease.A combination of both positively and negatively worded items is often employed in a survey to reduce participants' acquiescence bias, but such a combination may hurt the validity of the survey. The current study investigated the effect of valence of wording on participants' (N = 1132) responses to four versions of the Undergraduate Learning Burnout (ULB) scale. The results showed that the valence of wording affected a number of features of the scale. The internal consistency of both the original and the original-reverse versions (consisted of both positively and negatively worded items) was lower than that of the positive-only and the negative-only versions. The original and the original-reverse versions also had more factors than the positive-only and the negative-only versions. The original and the original-reverse versions showed method effects from both the positively and the negatively worded items, and those from the negatively worded items were stronger than those from the positively worded items. The method effects were predicted by participants' subjective well-being and future academic career plans. Together, this study suggests that using a combination of positively and negatively worded items can lead to a predictable response style and significant method effects, which reduce the scale's internal consistency and change the factor structure of the scale.Based on The Educational Situation Quality Model (MOCSE, acronym in Spanish) framework, the primary objective of this study is to test the factorial validity and reliability of two MOCSE measure instruments referred to the preactional-decisional phase, specifically to learning demands and teacher supports perceived by students to overcome such demands in the classroom context. The participants were 357 Spanish undergraduate students. The data obtained by exploratory and confirmatory factor analyses revealed that the "Learning Demands Scale" (MOCSE-LDS) has a two-factor structure perceived desirability and feasibility of demands. The data also revealed that the "Teacher Support Questionnaire" (MOCSE-TSQ) is composed of ten independent factors or subscales with good psychometric validity and reliability properties. Finally, the Student's t-test generally indicated that the constructs considered in the instruments did not differ in gender terms. In short, the results obtained for the validity and reliability of the two tested instruments were good.