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Furthermore, a static control redistribution mechanism is introduced to handle the actuator saturation which is responsible to re-allocate the excess control efforts to the available healthy actuators in the face of actuator saturation. Finally, a dual-pipe heat exchanger unit, modeled as DS, is simulated with proposed CA-based FTC such that the system can follow the time varying and constant reference trajectories in a situation of actuator faults and saturation. The simulation results are compared with the CA-based FTC where virtual control is designed based on super-twisting algorithm (STA) and with the traditional pseudo inverse-CA-based FTC to establish the superiority of the proposed scheme.In this paper, the stabilization of singularly perturbed systems by means of observer-based event-triggered control is studied. To obtain the ultimately bounded stability of the closed-loop system, two event-triggering conditions are designed, respectively, for the slow and the fast subsystems of the singularly perturbed systems based on the state errors between the observer and models. In each event-triggering condition, there are two different stages to be designed. In the first stage, the event-triggering conditions are given based on the observer error dynamics. While in the second stage, the absolute type event-triggering conditions are used. Under the designed event-triggering conditions, Zeno behavior can be eliminated from the closed-loop systems. Finally, numerical examples are provided to illustrate the efficiency and feasibility of the theoretical results.Deep neural networks have been successfully utilized in the mechanical fault diagnosis, however, a large number of them have been based on the same assumption that training and test datasets followed the same distributions. Unfortunately, the mechanical systems are easily affected by environment noise interference, speed or load change. Consequently, the trained networks have poor generalization under various working conditions. Recently, unsupervised domain adaptation has been concentrated on more and more attention since it can handle different but related data. Sliced Wasserstein Distance has been successfully utilized in unsupervised domain adaptation and obtained excellent performances. However, most of the approaches have ignored the class conditional distribution. In this paper, a novel approach named Join Sliced Wasserstein Distance (JSWD) has been proposed to address the above issue. https://www.selleckchem.com/products/lji308.html Four bearing datasets have been selected to validate the practicability and effectiveness of the JSWD framework. The experimental results have demonstrated that about 5% accuracy is improved by JSWD with consideration of the conditional probability than no the conditional probability, in addition, the other experimental results have indicated that JSWD could effectively capture the distinguishable and domain-invariant representations and have a has superior data distribution matching than the previous methods under various application scenarios.This paper addresses the problem of practical fixed-time trajectory tracking for wheeled mobile robots (WMRs) subject to kinematic disturbances and input saturation. Firstly, considering the under-actuated characteristics of the WMR systems, the WMR model under kinematic disturbances is transformed into a two-input two-output interference system by using a set of output equations. Then, the tracking error state equation with lumped disturbances in the acceleration-level pseudo-dynamic control (ALPDC) structure is established. The lumped disturbances are estimated by a designed fixed-time extended state observer (FESO) without requiring the differentiability of the first-time derivatives of the kinematic disturbances. Meanwhile, a practical fixed-time output feedback control law is developed for trajectory tracking. By resorting to the Lyapunov stability theorem, the fixed-time stability analysis of the closed-loop WMR system in the presence of input saturation is conducted. Finally, simulation results are presented to show the effectiveness of the proposed approach.This paper introduces an integrated path tracking control strategy for autonomous vehicles. The proposed control strategy is based on a multi-input multi-output linear model predictive control (LMPC) with a fuzzy logic switching system. The designed MPC is based on Laguerre networks. The main target of the designed MPC is to produce the optimal control signals of the steering angle and the angular velocity while considering the physical constraints of the control signals and the measurements noise. Since the vehicle model is highly nonlinear and is operated over a wide range of operating points, different linearized models are obtained. The controller parameters for each linear model are designed and tuned. The gab metric analysis is used to select a number of these models to simplify the design of the proposed controller. Then, these models are combined using a fuzzy logic controller to switch between them. To test the proposed controller performance, different paths are generated using path planning algorithms. These paths simulate different vehicle maneuvers scenarios. The simulation results show that the designed tracking controller has a tracking performance on different designed paths better than that of a Linear quadratic gaussian (LQG) tracking controller, discussed in this paper.Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain. It regulates lysosomal biogenesis, inflammation, repair, stress response, and aging. GRN loss-of-function mutations cause neuronal ceroid lipofuscinosis or frontotemporal dementia-GRN (FTD-GRN) in a gene dosage-dependent manner. Mutations that reduce PGRN levels increase the risk for developing Alzheimer's disease, Parkinson's disease, and limbic-predominant age-related transactivation response DNA-binding protein 43 encephalopathy, as well as exacerbate the progression of amyotrophic lateral sclerosis (ALS) and FTD caused by the hexanucleotide repeat expansion in the C9orf72 gene. Elevating and/or restoring PGRN levels is an attractive therapeutic strategy and is being investigated for neurodegenerative diseases through multiple mechanisms of action.The discovery of Mas-related G protein-coupled receptors (MRGPRs) in itch sensation promised a search for novel therapeutics of itch that ultimately met with little success. Recent structural determination of these receptors by Roth and Sun marks a big step forward in the search for therapeutics of debilitating itch.

We sought to compare the long-term outcomes of multiarterial graft (MAG) coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) with second-generation drug-eluting stents (DES) to treat stable multivessel coronary artery disease.

This study was a multicenter population-based retrospective analysis of all residents of Ontario, Canada, from January 1, 2011, to December 31, 2019. We identified 3600 cases of elective primary isolated CABG with MAG and 2187 cases of PCI with second-generation DES.

After the application of propensity score-weighting using overlap weights, MAG was associated with better survival over 5years compared with DES (96.8% vs 94.5%; hazard ratio [HR], 0.56; 95% CI, 0.37-0.85). MAG was also associated with better secondary outcomes including a composite of death, myocardial infarction, and stroke (94.3% vs 88.5%; HR, 0.49; 95% CI, 0.36-0.65). The rate of death, stroke, myocardial infarction, and repeat revascularization (91.2% vs 70.7%; HR, 0.24; 95% CI, 0.20-0.30), and the individual end points of myocardial infarction (1.4% vs 6.9%; HR, 0.22; 95% CI, 0.13-0.35), and repeat revascularization (4.1% vs 24.2%; HR, 0.14; 95% CI, 0.10-0.18) were lower with MAG. PCI with second-generation DES was associated with a lower rate of stroke up to 5years (0.6% vs 1.8%; HR, 3.97; 95% CI, 1.45-10.88).

CABG with MAG was associated with better survival and fewer major cardiac adverse events compared with second-generation DES and might be considered the treatment of choice for patients with stable multivessel coronary artery disease. Further randomized controlled trials are needed to confirm this hypothesis.

CABG with MAG was associated with better survival and fewer major cardiac adverse events compared with second-generation DES and might be considered the treatment of choice for patients with stable multivessel coronary artery disease. Further randomized controlled trials are needed to confirm this hypothesis.

To investigate the association between altered sex hormone expression and long-term right ventricular (RV) adaptation and progression of right heart failure in a Dutch cohort of Pulmonary Arterial Hypertension (PAH)-patients across a wide range of ages.

In this study we included 279 PAH-patients, of which 169 females and 110 males. From 59 patients and 21 controls we collected plasma samples for sex hormone analysis. Right heart catheterization (RHC) and/or cardiac magnetic resonance (CMR) imaging was performed at baseline. For longitudinal data analysis, we selected patients that underwent a RHC and/or CMR maximally 1.5 years prior to an event (death or transplantation, N=49).

Dehydroepiandrosterone-sulfate (DHEA-S) levels were reduced in male and female PAH-patients compared to controls, whereas androstenedione and testosterone were only reduced in female patients. Interestingly, low DHEA-S and high testosterone levels were correlated to worse RV function in male patients only. Subsequently, we analyzed prognosis and RV adaptation in females stratified by age. Females ≤45years had best prognosis in comparison to females ≥55years and males. No differences in RV function at baseline were observed, despite higher pressure-overload in females ≤45years. Longitudinal data demonstrated a clear distinction in RV adaptation. Although females ≤45years had an event at a later time point, RV function was more impaired at end-stage disease.

Sex hormones are differently associated with RV function in male and female PAH-patients. DHEA-S appeared to be lower in male and female PAH-patients. Females ≤45years could persevere pressure-overload for a longer time, but had a more severe RV phenotype at end-stage disease.

Sex hormones are differently associated with RV function in male and female PAH-patients. DHEA-S appeared to be lower in male and female PAH-patients. Females ≤45years could persevere pressure-overload for a longer time, but had a more severe RV phenotype at end-stage disease.Atherosclerosis is one of the two major causes of mortality worldwide along with cancer and is responsible for myocardial infarction, stroke, and arteritis. Its pathophysiology is still partially understood which allows doubts referring to the preventive and curative treatments. Population screening for atherosclerosis remains marginal even though it should be the common practice. To encourage preventive screening and therapies, we propose a simple and easily understandable pathophysiology of atherosclerosis, explaining how the brick-wall of atheroma is build inside the intima of arteries using a metaphor the LDL-cholesterol bricks, the oxidation cement, and the inflammatory mason.