Hvidkhan0147

Hepatitis B virus (HBV) infection is a major public health problem worldwide. The study aimed to evaluate the efficacy of pegylated interferon (Peg-IFN) alfa-2a treatment for seroclearance of HBs antigen (HBsAg) in HBe antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. This retrospective study investigated 16 HBeAg-negative CHB patients who received Peg-IFN alfa-2a weekly for 48 weeks. Thereafter, the patients were followed-up for 48 weeks after the end of therapy. The following criteria were also used for inclusion HBV-DNA  less then  5.0 log copies/mL and without nucleot(s)ide analogs. Four HBsAg-positive cases became HBsAg negative. The HBsAg levels of the 4 patients who achieved HBsAg seroclearance were lower significantly than that of the non-seroclearance group (p = 0.007). The mean HBsAg levels in these 4 cases were 68 IU/mL, while the mean HBsAg levels in the non-seroclearance group were 2,114 IU/mL. The mean HBV-DNA levels in the 4 HBsAg seroclearance cases were 2.8 log copies/mL as compared to 3.6 log copies/mL in HBsAg-non-seroclearance cases (p = 0.01). Cases that are HBeAg negative, with HBV-DNA levels  less then  5 log copies/mL, and HBsAg titers  less then  120 IU/mL cases may achieve HBsAg clearance with Peg-IFN therapy.

This study aimed to analyze the clinical and genetic characteristics of Chinese children with congenital hyperinsulinemia (CHI) that is spontaneously relieved.

The patient group comprised 200 children with CHI that were treated at the Beijing Children's Hospital from January 2006 to December 2018. The patients were divided into two groups according to their prognosis the spontaneous remission group (n = 92) and the nonspontaneous remission group (n = 108). The clinical characteristics, pathogenic genes, diagnosis and treatment process, and follow-up data of both groups were analyzed retrospectively.

Of the 200 children with CHI, 92 achieved spontaneous remission. The age of spontaneous remission was between one month and nine years, and 47 of the children were relieved before the age of one year. The median age of onset was 85 days (range 1-2825 days) in the spontaneous remission group and 2 days (range 1-210 days) in the nonspontaneous remission group (P < 0.05). The mean birth weight was 3.44 ± 0.7s remission of CHI was significantly higher in children with late age of CHI onset, light birth weight, effective diazoxide treatment, and no common pathogenic gene mutations. Spontaneous remission was also possible for a small number of children that carried mutations in the ABCC and KCNJ11 genes and in whom diazoxide treatment failed.

The rate of spontaneous remission of CHI was significantly higher in children with late age of CHI onset, light birth weight, effective diazoxide treatment, and no common pathogenic gene mutations. Spontaneous remission was also possible for a small number of children that carried mutations in the ABCC and KCNJ11 genes and in whom diazoxide treatment failed.Intestinal hypoganglionosis is a rare condition in adults. We report a case of intestinal hypoganglionosis in the mid-distal transverse colon to splenic flexure in a 65-year-old female patient presenting with altered bowel habit and abdominal distension, and reviewed the current literature on this topic. Our patient had a medical history of neurofibromatosis type 1. A preoperative computed tomography (CT) scan demonstrated a grossly dilated transverse colon without obstruction. A laparotomy for subtotal colectomy was performed, with histopathology demonstrating intestinal hypoganglionosis.

The SRS annual meeting (SRS-AM) represents the pinnacle of research in the field of spinal deformity. Spine surgery research was historically based on single-surgeon experience, but an increasing number of abstracts presented at SRS-AM are conducted by multicenter study groups, which may have improved the quality of literature available to surgeons. We sought to determine the proportion of SRS-AM podium presentations (PP) resulting from study groups over a 15-year period.

1874 PP from the 2005-2019 SRS-AM were reviewed to determine if they resulted from a study group or multicenter collaboration. Abstracts were also classified as pediatric- or adult-focused. Pearson correlations were calculated to analyze changes in the proportion of study group or multicenter PP.

The number of SRS PP increased from 102 to 171 from 2005 to 2019. 381 (20.3%) PP were identified as a study group product, while 536 (28.6%) resulted from multicenter collaboration. The proportion of study group PP increased by 0.9% annually from 8.8 to 26.9% (r

 = 0.44, p = 0.007), while multicenter PP increased by 1.2% annually from 11.8 to 40.9% (r

 = 0.51, p = 0.003). A greater proportion of study group PP were level of evidence I or II studies compared to those not resulting from the work of study groups (53.8 vs 19.3%, p < 0.001).

SRS-AM PP resulting from research study groups and multicenter collaborations increased over threefold from 2005 to 2019. Spine surgeons are taking a more proactive approach to produce more generalizable research with higher level of evidence through multicenter study groups, allowing them to make more informed decisions to ultimately improve surgical outcomes for patients.

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Consumption of sugar or artificially-sweetened beverages (SASBs) has been linked to albuminuria, decline in kidney function, and risk of chronic kidney disease (CKD). However, the results are controversial. We therefore aim to evaluate the effects of sugar or artificially-sweetened beverage consumption on CKD risk.

Original observational studies reporting relative risks (RRs) with 95% confidence intervals (CIs) for the association between sugar or artificially-sweetened beverage consumption and impaired renal function or CKD risk in adults were identified using a systematic search of PubMed and EMBASE from inception to 20 February, 2019. Random effects model was applied to derive summary RRs and 95% CIs. selleck Linear and non-linear dose-response relationships were estimated using data from sugar or artificially-sweetened beverage consumption categories in each study.

The summary RR of CKD for high versus low sugar-sweetened beverage consumption was 1.30 (95% CI 0.88-1.94) according to six included studies with a total of 25,455 participants, while the pooled RR of CKD for high versus low artificially sweetened beverage consumption was 1.