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New functional impairments are common at 30-days after discharge among survivors of hospitalization for COVID-19. Early rehabilitation, advance care planning, and referrals to appropriate therapies should be considered in post-acute COVID-19 care to maximize patients' functional outcomes, however ongoing research is still needed regarding management of these patients. This article is protected by copyright. All rights reserved.Combining photodynamic therapy (PDT) and immunotherapy has shown profound impact for synergistic treatment of malignant tumors. However, the shallow penetration depth of the traditional visible light activated PDT, immunosuppressive tumor microenvironment (TME), and poor immunogenicity of deep-seated solid tumors have significantly impeded the therapeutic efficiency. Herein, a soft X-ray activated nanoprobe is rationally engineered via integrating porphyrin Zr-based metal-organic framework with lanthanide NaYF4 Gd,Tb@NaYF4 scintillator nanoparticles (SNPs) by a new in situ growth strategy for synergistic PDT and immunotherapy of tumor. The nanoprobe possesses remarkably enhanced reactive oxygen species (ROS) generation triggered by soft X-ray via further covalently grafting rose bengal on the nanoprobe, even at tissue depths of 3 cm. Moreover, the soft X-ray induced ROS can act as potential immunogenic cell death (ICD) trigger, subsequently leading to the activation of the adaptive antitumor immune-response. Significantly, the boosted ROS generation can further modulate the immunosuppressive TME. This work provides new strategy of designing antitumor nanoprobes for soft X-ray triggered deep-tissue PDT and immune response, breaking the depth barriers suffered by the traditional photoactivated PDT or ICD using visible and near infrared light.The use of bioactive agents combined with osteoconductive scaffolds for the regeneration of periodontal intrabony defects has been the subject of intensive research in the past 20 years. Most studies reported that such agents, used in different concentrations, doses and combined with various scaffolds, might promote periodontal tissue regeneration, but evidence for the most effective combination of such agents is lacking. The objective of this study 13 was to rank the different combinations of recombinant human-derived growth and differentiation factors with/without scaffold biomaterial in the treatment of periodontal intrabony defects, through network meta-analysis of pre-clinical studies. The systematic review and network meta-analysis protocol was registered on the PROSPERO Systematic Review database with reference number CRD42021213673. Relevant published articles were obtained after searching five electronic databases. A specific search strategy was followed by using keywords related to intrabony defectsctive agents may depend on clinical needs and purpose.

The COVID-19 pandemic catalyzed the adoption of telerehabilitation in various healthcare settings. However, there was neither a pre-existing national guideline in the Philippines nor an internationally agreed standard on telerehabilitation. The literature lacks nationwide studies documenting how physiatrists perceived and experienced telerehabilitation during the pandemic.

To determine the perceptions and experiences of physiatrists in the Philippines regarding telerehabilitation.

Online survey originally developed by the authors with inputs from local experts in telehealth or telerehabilitation.

Nationwide, involving board-certified physiatrists practicing in the Philippines.

Fellows of the Philippine Academy of Rehabilitation Medicine (PARM) (N=259) with Internet access.

Self-reported telerehabilitation knowledge, skills, and experience; key concerns; preferred clients, service offerings, and methods (technology, duration, charging).

The respondents (n=161; 62.2% response-rate) had a mean age ng telerehabilitation, many physiatrists in the Philippines learned to adopt this service delivery method during the pandemic. Their perceptions and experiences could be used in formulating practice-based guidelines and strategies to improve the conduct of telerehabilitation in the country. This article is protected by copyright. All rights reserved.

Despite their limited baseline knowledge, skills and experience regarding telerehabilitation, many physiatrists in the Philippines learned to adopt this service delivery method during the pandemic. Their perceptions and experiences could be used in formulating practice-based guidelines and strategies to improve the conduct of telerehabilitation in the country. This article is protected by copyright. All rights reserved.Chemical reaction yield is one of the most important factors for determining reaction conditions. Recently, several machine learning-based prediction models using high-throughput experiment (HTE) data sets were reported for the prediction of reaction yield. However, none of them were at a practical level in terms of predictive ability. In this study, we propose a message passing neural network (MPNN) model for chemical yield prediction, focusing on the Buchwald-Hartwig cross-coupling HTE data set. As an initial atom embedding in MPNN model, we propose to use the Mol2Vec feature vectors pre-trained using a large compound database. Predictive ability of the proposed model was higher than that of previously reported five models for the three out of five data sets. Moreover, visualization of important atoms based on self-attention mechanism was in favor of Mol2Vec as an atom embedding rather than other embeddings including previously employed simple representations.

Substantial evidence demonstrates the harms of pregnancy smoking. Due to the need for very large data sets, less data exist to inform decisions about when quitting should occur, or whether a certain amount of reduction is beneficial.

Our goal was to examine the effect of timing and amount of pregnancy smoking on low birth weight (LBW) and preterm birth (PTB).

Data for 3 years of registered births in Tennessee were available and included standard birth certificate information.

Of 241,616 women, 15.7% smoked at conception, and those who quit as early as the first trimester had significantly increased adjusted odds of LBW (27%) and PTB (14%) compared to nonsmokers, with this effect largely driven by smoking 10+ cigarettes per day. Smoking into the second trimester but quitting prior to the third also predicted increases in LBW and PTB compared to both not smoking at all and smoking only in the first trimester. Smoking to delivery predicted a 2.8-fold increased likelihood of LBW, and a 2.1-fold increased rate of PTB. Any level of smoking after the first trimester substantially increased the odds of poor outcomes compared to both nonsmoking and smoking only in the first trimester.

Findings suggest that to avoid LBW or PTB, pregnant smokers should be advised that quitting completely by the end of the first trimester is important, and that continuing to smoke even <5 cigarettes per day after that point substantially increases the potential for of adverse outcomes.

Findings suggest that to avoid LBW or PTB, pregnant smokers should be advised that quitting completely by the end of the first trimester is important, and that continuing to smoke even less then 5 cigarettes per day after that point substantially increases the potential for of adverse outcomes.

Skeletal muscle mass begins to decline from 40years of age. Limited data suggest that dietary fibre may modify lean body mass (BM), of which skeletal muscle is the largest and most malleable component. We investigated the relationship between dietary fibre intake, skeletal muscle mass and associated metabolic and functional parameters in adults aged 40years and older.

We analysed cross-sectional data from the US National Health and Nutrition Examination Survey between 2011 and 2018 from adults aged 40years and older. Covariate-adjusted multiple linear regression analyses were used to evaluate the association between dietary fibre intake and BM components (BM, body mass index [BMI], total lean mass, appendicular lean mass, bone mineral content, total fat, trunk fat; n=6454), glucose homeostasis (fasting glucose, fasting insulin, HOMA2-IR; n=5032) and skeletal muscle strength (combined grip strength; n=5326). BM components and skeletal muscle strength were expressed relative to BM (per kg of BM).

Higher iower BM and enhanced body composition, characterized by a reduction in fat mass and an increase in lean mass. Higher dietary fibre intakes were also associated with improvements in glucose homeostasis and skeletal muscle strength. Increasing dietary fibre intake may be a viable strategy to prevent age-associated declines in skeletal muscle mass.

Higher dietary fibre intakes are associated with a lower BM and enhanced body composition, characterized by a reduction in fat mass and an increase in lean mass. Higher dietary fibre intakes were also associated with improvements in glucose homeostasis and skeletal muscle strength. Increasing dietary fibre intake may be a viable strategy to prevent age-associated declines in skeletal muscle mass.

Rubinstein-Taybi syndrome (RSTS) is a rare genetic syndrome caused primarily by a mutation in the CREBBP gene found on chromosome 16. Patients with RSTS are at greater risk for a variety of medical problems, including upper airway obstruction and aspiration. Childhood interstitial lung disease (ILD) thus far has not been definitively linked to RSTS. Here we present three patients with RSTS who developed ILD and discuss possible mechanisms by which a mutation in CREBBP may be involved in the development of ILD.

Routine hematoxylin and eosin staining was performed on lung biopsy tissue for histological analysis. selleck chemical Immunofluorescent staining was performed on lung biopsy tissue for markers of fibrosis, surfactant deficiency and histone acetylation. Cases 1 and 2 had standard clinical microarray analysis. Case 3 had whole exome sequencing. Bioinformatics analyses were performed to identify possible causative genes using ToppGene.

CT images in all cases showed consolidated densities overlying ground glass opacio possible mechanisms for the development of ILD abnormal surfactant metabolism and/or persistent activation of myofibroblasts. These two pathways could be related to dysfunctional CREBBP protein. This article is protected by copyright. All rights reserved.Once known solely from dental material and thought to represent an early ornithischian dinosaur, the early-diverging pseudosuchian Revueltosaurus callenderi is described from a minimum of 12 skeletons from a monodominant bonebed in the upper part of the Chinle Formation of Arizona. This material includes nearly the entire skeleton and possesses a combination of plesiomorphic and derived character states that help clarify ingroup relationships within Pseudosuchia. A phylogenetic analysis recovers R. callenderi in a clade with Aetosauria and Acaenasuchus geoffreyi that is named Aetosauriformes. Key autapomorphies of R. callenderi include a skull that is longer than the femur, a complete carapace of dermal armor including paramedian and lateral rows, as well as ventral osteoderms, and a tail end sheathed in bone. Histology of the femur and associated osteoderms demonstrate that R. callenderi was slow growing and that the individuals from the bonebed were not young juveniles but had not ceased growing. A review of other material assigned to Revueltosaurus concludes that the genus cannot be adequately diagnosed based on the type materials of the three assigned species and that only R.