Emborgkarlsson5740

uce return visits.

To describe the current state of telemedicine within pediatric training programs to inform development of a national telemedicine training curriculum for pediatric trainees.

We conducted an anonymous cross-sectional survey of pediatric residency (Fall 2020) and fellowship program directors (Spring 2021) on their current telemedicine practices in pediatric post-graduate training.

Forty-eight U.S. pediatric residency programs (n=48/198, 24%) and 422 fellowship programs completed the survey (n=422/872, 48%); combined response rate 44% (n=470/1,070). Pre-COVID-19, 12% (n=57/470) of programs surveyed reported using telemedicine in their training program, but during the pandemic 71% (n=334/470) reported telemedicine use with trainees. Over 71% (n=334/470) agreed that a formalized curriculum is important, yet 69% (n=262/380) of programs reporting telemedicine use either did not have a curriculum or were unsure if one existed at their program. Respondents who were unsure/not likely to add a telemedicine curriculum and/or indicated that a telemedicine curriculum would not be important (52% n=243/470), cited "time" (55%, n=136/243) most frequently as a barrier.

Our needs assessment indicates marked increase in use of telemedicine with trainees by respondent pediatric training programs, with fewer than 50% reporting a formalized training curriculum and most agreeing that a curriculum is important.

Our needs assessment indicates marked increase in use of telemedicine with trainees by respondent pediatric training programs, with fewer than 50% reporting a formalized training curriculum and most agreeing that a curriculum is important.

Determination of the effect of hysterectomy due to benign diseases on female sexual function DATA SOURCES A search was performed on Scopus, PubMed, Science Direct, ProQuest, ISI Web of Knowledge and Embase databases. The keywords included Hysterectomy (as exposure) and Female sexual function (as outcome). Original English observational studies, including cohort, case-control, and cross-sectional studies published as of February 2021, which reported an association between any type of hysterectomy due to benign female disease and sexual function as an outcome, were included in the study. Studies in participants who received HRT and had sex other than heterosexuals were not included. There was no limit to the initial search period, and articles published by February 2021 were searched.

The search process resulted in the retrieval of 5,587 potentially related articles. After removing duplicated studies, the title and abstract were reviewed and 77 articles remained with the removal of unrelated items. The fullrisons were made between Total and supracervical/total). Pooled SMD was affected by type of sexual function scale, World Bank countries' classification, type of hysterectomy, ovary status, and reproductive status. The results of meta-regression analysis also showed that for each month of distance from hysterectomy, women's sexual function score increases by .18.

The results of the present study showed that hysterectomy due to benign disease does not change the sexual function significantly.

The study protocol was registered in PROSPERO system with the code CRD42021228314.

The study protocol was registered in PROSPERO system with the code CRD42021228314.

To evaluate the choroidal thickness (CT) with enhanced depth-imaging optical coherence tomography (EDI-OCT) in healthcare professionals using surgical masks or FFP2 (N95) masks.

We included the 120 eyes of 120 healthy volunteers who were using a surgical mask (Group 1) or FFP2 mask (Group 2) in the study. Spectral domain (SD) OCT was used to measure CT. EDI-OCT was used to measure subfoveal and perifoveal CT. Points 1500 μm nasal (C

) and temporal (C

) to the foveal center were used to measure perifoveal CT. Oxygen saturation and heart rate were measured with a pulse oximeter. All measurements were performed at 830, before wearing the mask, and at 1230, when the mask was removed for the lunch break.

Of a total of 120 subjects, Group 1 consisted of 60 subjects (mean age 38.50±8.60 (range 24-44) years) and Group 2 also consisted of 60 subjects (mean age 36.60±6.53 (range 26-45) years). Although not statistically significant, CT was seen to have increased at 3 measurement points in Group 1 after using the mask for 4 hours subfoveal CT (C

) (p=0.545), C

(p=0.080), and C

(p=0.251)). In Group 2, the increase in C

(p=0.001) was statistically significant while the increases in C

and C

were not (p=0.162 and p=0.058, respectively) after using the mask for 4 hours.

We found CT to increase after 4 hours of mask use, and this increase was more marked in Group 2. The increase in subfoveal CT in particular was statistically significant in Group 2.

We found CT to increase after 4 hours of mask use, and this increase was more marked in Group 2. The increase in subfoveal CT in particular was statistically significant in Group 2.Hemolytic anemia and secondary hypoxia are characteristics of naturally occurring Babesia bigemina infection in cattle. The anemic phase comes with cardiovascular insufficiency due to hypoxia-induced system dysfunction; but to date there is no description of cardiac damage in the infected animals. Therefore, this study was undertaken to investigate hematological parameters, biomarkers of cardiac function and D-dimer in 13 cattle infected with B. bigemina which were unresponsive to standard treatment. The animals were necropsied and the cardiac tissue was examined for histopathologic alterations. A significant parasitemia burden-dependent increase in the cardiac biomarkers and D-dimer level were recorded in the infected cattle compared to the control animals. Thrombocytes count was also significantly lower in the infected animals than the control. Both macroscopic and microscopic hemorrhage, mononuclear infiltrates, and myocardial necrosis were the evident histopathologic findings. These findings suggest that B. bigemina infection can potentially induce cardiac dysfunction in cattle. see more Furthermore, mechanistic studies should be conducted to understand the mechanisms beyond cardiac complications.Tofu processing residues (TPR) have received more attention as a source of bioenergy. However, their low solubility has hindered biohythane generation. Consequently, the ultrasonic and H2SO4 pretreatments were combined and compared for the first time to improve the hydrolysis of organic matter and carbohydrate and increase free amino nitrogen generation from TPR. Besides, the impact of pretreatments on biohythane generation was investigated. Under the optimal conditions of 7.54% substrate level, 8% H2SO4 concentration, 80 °C and 50 min, the coincident ultrasonic-H2SO4 pretreatment enriched the contents of soluble chemical oxygen demand, reducing sugar, and free amino nitrogen to 49675 mg/L, 26 g/L, and 1721 mg/L, respectively, greater than individual pretreatments. Also, Biohythane yield increased by 4.24-13.61% over control (389.42 ± 23.7 ml/g-VSfed). Furthermore, hydrogen yield at 42.5 ± 2.08 and 28.1 ± 1.07 ml/g-VSfed and sulfate removal efficiency at 93 and 92% were significantly improved with ultrasonic-H2SO4 and H2SO4 pretreatments, respectively, indicating acidogenic and sulfidogenic activity enhancement.Microalgae cultivating in wastewater enabling nutrient uptake for biomass and biofuel generation is regarded as a promising pathway to increase sustainability of microalgae biofuel production process. A source-separated nutrient organization approach for the process of wastewater-based microalgae biofuel is proposed in this study. Comparative life cycle assessment (LCA) method and Techno-economic analysis (TEA) approach are employed to assess sustainability and economic performance of the proposed nutrient approach. Two scenarios are used to validate our study. Scenario 1 is based on the source-separated nutrient delivery approach with microalgae integrated wastewater in tertiary treatment. Scenario 2 is based on non-separated-point nutrient delivery policy and microalgae integrated with secondary wastewater treatment. The results show that the source-separated nutrient approach is effective for reducing the environmental impacts and increasing commercial potential of microalgae biofuel.Phthalates are well-known emerging contaminants that harm human health and the environment. Therefore, this review aims to discuss about the occurrence, fate, and phthalates concentration in the various environmental matrices (e.g., aquatic, sediment, soil, and sewage sludge). Hence, it is necessary to treat sources containing phthalates before discharging them to aqueous environment. Various advanced wastewater treatments including adsorption process (e.g., biochar, activated carbon), advanced oxidation processes (e.g., photo-fenton, ozonation, photocatalysis), and biological treatment (membrane bioreactor) have been successfully to address this issue with high removal efficiencies (70-95%). Also, the degradation mechanism was discussed to provide a comprehensive understanding of the phthalate removal for the reader. Additionally, key factors that influenced the phthalates removal efficiency of these technologies were identified and summarized with a view towards pilot-scale and industrial applications.The remediation of multiple pollutants in water, for instance, nitrate, heavy metals, and antibiotics is urgent and necessary for the global water resources protection. Herein, a modified loofah bioreactor was designed for simultaneous denitrification, manganese (Mn) oxidation, and tetracycline (TC) removal. The maximum removal efficiencies of NO3--N (91.97%), Mn(II) (71.25%), and TC (57.39%) were achieved at a hydraulic retention time (HRT) of 9 h, Mn(II) concentration of 20 mg L-1, and TC concentration of 1 mg L-1. SEM and XRD were carried out to characterize the bioprecipitation in the operation of bioreactor. TC addition affected the gaseous denitrification products, dissolved organic matter, as well as reduced the OTU in the bioreactor. The Zoogloea were regarded as the dominant species in the microbial community and played an essential role in the operation of bioreactor. Metagenomic analysis proved the great potential for denitrification, manganese oxidation, and antibiotic removal of loofah bioreactor.Survival and expansion of malignant B cells in chronic lymphocytic leukemia (CLL) are highly dependent both on intrinsic defects in the apoptotic machinery and on the interactions with cells and soluble factors in the lymphoid microenvironment. The adaptor protein p66Shc is a negative regulator of antigen receptor signaling, chemotaxis and apoptosis whose loss in CLL B cells contributes to their extended survival and poor prognosis. Hence, the identification of compounds that restore p66Shc expression and function in malignant B cells may pave the way to a new therapeutic approach for CLL. Here we show that a novel oxazepine-based compound (OBC-1) restores p66Shc expression in primary human CLL cells by promoting JNK-dependent STAT4 activation without affecting normal B cells. Moreover, we demonstrate that the potent pro-apoptotic activity of OBC-1 in human leukemic cells directly correlates with p66Shc expression levels and is abrogated when p66Shc is genetically deleted. Preclinical testing of OBC-1 and the novel analogue OBC-2 in Eμ-TCL1 tumor-bearing mice resulted in a significantly longer overall survival and a reduction of the tumor burden in the spleen and peritoneum.