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All samples amplifying a product in the com1 assay also amplified a product in the htpAB and IS1111 assays. A total of 17/58 (29%) packets were positive with all three genes, 4/58 (7%) were positive with two genes (IS1111 and htpAB) and 4/58 (7%) were positive with the IS1111 gene only. Coxiella burnetii DNA was five times more likely to be found in offal than skeletal muscle meat samples. All meat samples in which C. burnetii DNA was found were from kangaroo tissues, while samples labelled as non-kangaroo meat (n = 4) were negative. Multi-locus variable number of tandem repeat analysis (MLVA) identified three different genotypes of C. burnetii that have all been identified previously from Australian human clinical Q fever cases. Further investigations are required to determine the potential role of certain raw meats in the transmission of C. burnetii to cats and humans. © 2020 Blackwell Verlag GmbH.BACKGROUND Pharmacogenomics plays a crucial role in individualized therapy, but the variant information of pharmacogenomics in the Dai population is limited. We therefore aimed to screen very important pharmacogenetic (VIP) in the Dai population and compared differences between Dai and other 25 populations. METHODS In this study, we genotyped 73 VIP variants from the PharmGKB and compared genotype distribution of variants in Dai with other 25 populations by χ2 test. To assess the genetic relationship among 26 populations, we performed the structure analysis. In addition, pair-wise F-statistics (Fst) was calculated to measure the population differentiation. RESULTS We found 12, 10, 13, 17, 11, 39, 46, 46, 45, 43, 49, 46, 46, 46, 49, 45, 41, 42, 48, 53, 45, 50, 50, 51, 47, and 50 significantly different variants in Dai compared with other 25 populations. Genetic structure analysis showed Dai had close relationships with CDX (Chinese Dai in Xishuangbanna), CHB (Han Chinese in Beijing), JPT (Japanese in Tokyo), and KHV (Kinh in Ho Chi Minh City, Vietnam). Moreover, Dai is the most similar to KHV according to Fst analysis. NVP-BGT226 molecular weight CONCLUSIONS Our study complement the pharmacogenomics information of Dai population from Yunnan province and provide a theoretical basis for personalized medicine. © 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.All about Organic Guest Editors Philippe Poizot, Yan Yao, Jun Chen, and Ulrich S. Schubert provide their thoughts on organic batteries-the challenges they face, their advantages and disadvantages, and what needs to be done to make them a commercially viable option-in this preface to a special issue of ChemSusChem on organic batteries, with highly interesting contributions from scientists around the world. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.OBJECTIVES Research into adolescent mental health has tended to focus on primary attachment relationships. However, the effect of secondary attachment relationships and the role of culture remain under-explored. This study examined the associations between primary attachment, secondary attachment, and coping strategies (task-focused, emotion-focused, and avoidant coping) with psychological well-being and psychological distress in adolescents across two cultural settings. DESIGN A cross-sectional study. METHOD An identical test battery was used across two geographic sites in Pakistan (N = 510; 12-18 years; 51.5% male; mean age = 14.50) and Scotland (N = 610; 12-18 years; 53.6% male; mean age = 13.97). Associations were tested separately in each sample using moderated mediation modelling for the outcome variables psychological well-being and psychological distress. RESULTS For psychological well-being, all three coping strategies were significant partial mediators and secondary attachment was a significant modeh primary attachment and secondary attachment security to enhance psychological well-being and lessen psychological distress. Cross-cultural differences in coping suggest that differential strategies to target different coping dimensions may enhance adolescent well-being across cultures. These cross-cultural differences highlight the ethical importance of cultural sensitivity among clinicians working with adolescents globally. © 2020 The Authors. Psychology and Psychotherapy Theory, Research and Practice published by John Wiley & Sons Ltd on behalf of British Psychological Society.Invited for this month's cover is the group of Dr. Robert Göstl at DWI - Leibniz Institute for Interactive Materials, Germany. The cover shows the mechanochemically induced retro Diels-Alder reaction of the adduct of a π-extended anthracene and maleimide yielding highly fluorescent anthracenes. This mechanophore motif as well as other force-responsive molecules are reviewed with regard to their efficient activation and quantification. Read the full text of the Minireview at 10.1002/cplu.201900737. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Hydrocephalus is characterized by increased cerebrospinal fluid within the brain, a causally heterogeneous disorder estimated to affect 1 per 1,000 live births, with the most severe cases often leading to fetal demise. The large number of known genetic and environmental factors that contribute to hydrocephalus makes the differential diagnosis challenging. CASES Three consecutive pregnancies of an unrelated couple were found by ultrasound to carry fetuses with hydrocephaly. DNA from two affected fetuses and the parents were subjected to whole exome sequencing. Heterozygous alterations in the TRAPPC12 gene were identified in the parents and compound heterozygous alterations were present in the two affected fetuses. The variant from the father (c.954del) leads to a premature termination of the transcript; the variant from the mother (c.1677+5G>A) affects a splice site which leads to aberrant splicing of the TRAPPC12 transcript. CONCLUSION Compound heterozygous variants in TRAPPC12, which encodes a protein involved in Golgi trafficking and mitosis, may disrupt normal brain embryogenesis leading to hydrocephalus and recurrent pregnancy loss. © 2020 Wiley Periodicals, Inc.