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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of design that include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A practical trial that employs a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. A high degree of heterogeneity, however can result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market, provides various classic table games like Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta provide a genuine gambling experience for customers and offer an extensive selection of virtual betting options. The company has also created various interactive games to make online gambling fun. Some of these shows are hosted live and some are hosted by famous personalities from the industry.

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Pragmatic Play offers not only mobile-friendly slot machines but also table games and live casino. Pragmatic Play is licensed by various regulatory bodies which include Malta Gaming Authority and UK Gambling Commission. The company's games are secured with high-end encryption and its security staff is available to assist players in any situation.

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Pragmatic Play offers a large number of games that you can play for free before deciding whether you want to purchase them. These games are made to run on all kinds of devices including tablets, desktops and smartphones. They are easy to navigate and you can play from anywhere with an internet connection. Some Pragmatic Play websites even let you test your luck while on the move with a practice mod. This can help you become familiar with the game's rules and features prior to playing for real money.

Legality

Pragmatic Play has earned a reputation for providing top-notch games and an exceptional user experience. Its software can be used on mobile devices and in a variety of languages. It has established itself as one of the most popular gaming platforms in the casino industry despite its relatively young age. The most recent releases include Wolves 5 reel video slot that has a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. Usually, they are commissioned by policymakers and practitioners to inform their decisions. They can be used to determine the causality of an intervention and its effects. They should not, however be used to replace explanation studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or clinical hypothesis and pragmatic trials, which inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study which includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.