Hegelundhvass6954

We compare inter-region patterns. Median temperature over the peripheral regions decreased from baseline after both challenges (maximum decrease [Formula see text] °C at 60 s after exercise; [Formula see text] and [Formula see text] °C at 180 s of cold-water immersion; [Formula see text]). Median temperature over the central regions showed no significant changes. Our results show that the non-contact measurement of perfusion-related changes in peripheral temperature from infrared video data is feasible. Further research will be directed towards the thermographic study of patients with symptomatic peripheral vascular disease.

A new numerical modeling approach is proposed which provides forward-problem solutions for both noninvasive recordings (EEG/MEG) and higher-resolution intracranial recordings (iEEG).

The algorithm is our recently developed boundary element fast multipole method or BEM-FMM. It is based on the integration of the boundary element formulation in terms of surface charge density and the fast multipole method originating from its inventors. The algorithm still possesses the major advantage of the conventional BEM - high speed - but is simultaneously capable of processing a very large number of surface-based unknowns. As a result, an unprecedented spatial resolution could be achieved, which enables multiscale modeling.

For non-invasive EEG/MEG, we are able to accurately solve the forward problem with approximately 1 mm anatomical resolution in the cortex within 1-2 min given several thousand cortical dipoles. Targeting high-resolution iEEG, we are able to compute, for the first time, an integrated electromagnetic response for an ensemble (2,450) of tightly packed realistic pyramidal neocortical neurons in a full-head model with 0.6mm anatomical cortical resolution. The neuronal arbor is comprised of 5.9 M elementary 1.2μm long dipoles. On a standard server, the computations require about 5min.

Our results indicate that the BEM-FMM approach may be well suited to support numerical multiscale modeling pertinent to modern high-resolution and submillimeter iEEG.

Based on the speed and ease of implementation, this new algorithm represents a method that will greatly facilitate simulations at multi-scale across a variety of applications.

Based on the speed and ease of implementation, this new algorithm represents a method that will greatly facilitate simulations at multi-scale across a variety of applications.Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic conditions. The current assessment of COPD requires a maximal maneuver during a spirometry test to quantify airflow limitations of patients. Other less invasive measurements such as thoracic bioimpedance and myographic signals have been studied as an alternative to classical methods as they provide information about respiration. Particularly, strong correlations have been shown between thoracic bioimpedance and respiratory volume. The main objective of this study is to investigate bioimpedance and its combination with myographic parameters in COPD patients to assess the applicability in respiratory disease monitoring. We measured bioimpedance, surface electromyography and surface mechanomyography in forty-three COPD patients during an incremental inspiratory threshold loading protocol. We introduced two novel features that can be used to assess COPD condition derived from the variation of bioimpedance and the electrical and mechanical activity during each respiratory cycle. These features demonstrate significant differences between mild and severe patients, indicating a lower inspiratory contribution of the inspiratory muscles to global respiratory ventilation in the severest COPD patients. In conclusion, the combination of bioimpedance and myographic signals provides useful indices to noninvasively assess the breathing of COPD patients.

Septic shock is a life-threatening manifestation of infection with a mortality of 20-50% [1]. A catecholamine vasopressor, norepinephrine (NE), is widely used to treat septic shock primarily by increasing blood pressure. For this reason, future blood pressure knowledge is invaluable for properly controlling NE infusion rates in septic patients. However, recent machine learning and data-driven methods often treat the physiological effects of NE as a black box. In this paper, a real-time, physiology-informed human mean arterial blood pressure model for septic shock patients undergoing NE infusion is studied.

Our methods combine learning theory, adaptive filter theory, and physiology. We learn least mean square adaptive filters to predict three physiological parameters (heart rate, pulse pressure, and the product of total arterial compliance and arterial resistance) from previous data and previous NE infusion rate. These predictions are combined according to a physiology model to predict future mean arterial blood pressure.

Our model successfully forecasts mean arterial blood pressure on 30 septic patients from two databases. Specifically, we predict mean arterial blood pressure 3.33 minutes to 20 minutes into the future with a root mean square error from 3.56 mmHg to 6.22 mmHg. find more Additionally, we compare the computational cost of different models and discover a correlation between learned NE response models and a patient's SOFA score.

Our approach advances our capability to predict the effects of changing NE infusion rates in septic patients.

More accurately predicted MAP can lessen clinicians' workload and reduce error in NE titration.

More accurately predicted MAP can lessen clinicians' workload and reduce error in NE titration.

Most MRI scanners are equipped to receive signals from

H array coils but few support multi-channel reception for other nuclei. Using receive arrays can provide significant SNR benefits, usually exploited to enable accelerated imaging, but the extension of these arrays to non-

H nuclei has received less attention because of the relative lack of broadband array receivers. Non-

H nuclei often have low sensitivity and stand to benefit greatly from the increase in SNR that arrays can provide. This paper presents a cost-effective approach for adapting standard

H multi-channel array receivers for use with other nuclei - in this case,

C.

A frequency translation system has been developed that uses active mixers residing at the magnet bore to convert the received signal from a non-

H array to the

H frequency for reception by the host system receiver.

This system has been demonstrated at 4.7T and 7T while preserving SNR and isolation.

H decoupling, particularly important for

C detection, can be straightforwardly accommodated.