Borghamilton5396
Chevron osteotomy for the treatment of mild and moderate hallux valgus obtain good effects. The procedure is suitable for a variety of cases, thereby allowing for a significant degree of correction. This study aimed to investigate Chevron osteotomy procedures for the correction of hallux valgus in the medium-term (2010-2016) by podiatrists surgeons. It takes into account clinical and radiological findings as well as patient perspectives and level of satisfaction.
All patients were assessed preoperatively, postoperatively and at a final follow-up. Fifty feet (forty five patients). The mean age was 59.43 (range 32 to 80) years. All of the participants signed an informed consent form to take part in the study. DNA Damage inhibitor The protocols include chart review, clinical and radiological. Anterior-posterior weight-bearing radiographs were analyzed preoperatively and at final follow-up. All radiological data were assessed by two observers blinded. Clinical and functional measurements as well as evaluation of the satisfaction howed that radiological results at final follow-up weren´t compatible with relapse of the deformity. The definitive clinical results, and the degree of patient satisfaction achieved with this technique were favorable from the patients' point of view.
Many diseases have a metabolic background, which is increasingly investigated due to improved measurement techniques allowing high-throughput assessment of metabolic features in several body fluids. Integrating data from multiple cohorts is of high importance to obtain robust and reproducible results. However, considerable variability across studies due to differences in sampling, measurement techniques and study populations needs to be accounted for.
We present Metabolite-Investigator, a scalable analysis workflow for quantitative metabolomics data from multiple studies. Our tool supports all aspects of data pre-processing including data integration, cleaning, transformation, batch analysis as well as multiple analysis methods including uni- and multivariable factor-metabolite associations, network analysis and factor prioritization in one or more cohorts. Moreover, it allows identifying critical interactions between cohorts and factors affecting metabolite levels and inferring a common covariate model, all via a graphical user interface.
We constructed Metabolite-Investigator as a free and open web-tool and stand-alone Shiny-app. It is hosted at https//apps.health-atlas.de/metabolite-investigator/, the source code is freely available at https//github.com/cfbeuchel/Metabolite-Investigator.
Supplementary data are available at Bioinformatics online.
Supplementary data are available at Bioinformatics online.
Although genome-wide association studies (GWASs) have identified thousands of variants for various traits, the causal variants and the mechanisms underlying the significant loci are largely unknown. In this study, we aim to predict noncoding variants that may functionally affect translation initiation through long-range chromatin interaction.
By incorporating the Hi-C data, we propose a novel and powerful deep learning model (DeepHiC) of artificial intelligence to classify interacting and non-interacting fragment pairs and predict the functional effects of sequence alteration of single nucleotide on chromatin interaction and thus on gene expression. The changes in chromatin interaction probability between the reference sequence and the altered sequence reflect the degree of functional impact for the variant. The model was effective and efficient with the classification of interacting and non-interacting fragment pairs. The predicted causal SNPs that had a larger impact on chromatin interaction were more likely to be identified by GWAS and eQTL analyses. We demonstrate that an integrative approach combining artificial intelligence - deep learning with high throughput experimental evidence of chromatin interaction leads to prioritizing the functional variants in disease- and phenotype-related loci and thus will greatly expedite uncover of the biological mechanism underlying the association identified in genomic studies.
Source code used in data preparing and model training is available at the GitHub website (https//github.com/biocai/DeepHiC).
Supplementary data are available at Bioinformatics online.
Supplementary data are available at Bioinformatics online.
Cognitive dispersion, or inconsistencies in performance across cognitive domains, has been posited as a cost-effective tool to predict conversion to dementia in older adults. However, there is a dearth of studies exploring cognitive dispersion in the oldest-old (>80years) and its relationship to dementia incidence.
The main aim of this study was to examine whether higher cognitive dispersion at baseline was associated with dementia incidence within an 8-year follow-up of very old adults, while controlling for established risk factors and suggested protective factors for dementia.
Participants (n = 468) were from the Origins of Variance in the Old-Old Octogenarian Twins study, based on the Swedish Twin Registry. Cox regression analyses were performed to assess the association between baseline cognitive dispersion scores and dementia incidence, while controlling for sociodemographic variables, ApoEe4 carrier status, co-morbidities, zygosity and lifestyle engagement scores. An additional model included pon cognition in very advanced age.Previous claims of the number of color categories and corresponding basic color terms in modern Mandarin Chinese remain irreconcilable, mainly due to the shortage in objectively evaluating the basicness of color terms with statistical significance. Therefore the present study applied k-means cluster analysis to investigate native Mandarin Chinese speakers' color naming data of 330 color chips similar to those used in World Color Survey. Results confirmed that there are 11 basic color categories among modern Mandarin speakers in Taiwan, one corresponding to each basic color term. Results also showed that observers overwhelmingly agreed in their use of Mandarin color terms, including those that had yielded ambiguous results in previous studies (gray, brown, pink, and orange). There is significant cross-language similarity when comparing the distribution of color categories in the World Color Survey chart with American English and Japanese data. The motif analysis and group mutual information analysis suggest that Mandarin color terms used in Taiwan describe very similar categories and are, hence, similarly precise in communicating color information as those in Japanese and American English.
