Ennisenevoldsen6951

The adsorption and recovery of dysprosium ions (Dy3+) from industrial wastewater are necessary but still challenging. Herein, we constructed a series of defect-containing metal-organic frameworks (MOFs) [UiO-66-(COOH)2] using sodium benzoate (BCNa) as a modulator. Upon the formation of defects, the porosity and surface charge properties of the MOFs were improved, leading to a higher utilization ratio of active groups and higher adsorption capacities for Dy3+. The synthesized UiO-66-(COOH)2-B10 with an optimal addition of BCNa exhibited a superior adsorption capacity of 150.6 mg g-1. Fast adsorption occurred at ∼5 min, and equilibrium was reached at ∼60 min. Higher pH and temperature were found to be beneficial for boosting Dy3+ adsorption, and selective adsorption over other metal ions was achieved in a multicomponent solution. Further, FTIR spectroscopy and XPS investigations indicate that free carboxyl contributes to the capture of Dy3+. Thus, this work provides a promising strategy to enhance the utilization ratio of active groups and further adsorption performance.Dissolved organic matter (DOM) plays an important role in soil structure and biogeochemical function development, which are fundamental for the eco-engineering of tailings-soil formation to underpin sustainable tailings rehabilitation. In the present study, we have characterized the DOM composition and its molecular changes in an alkaline Fe ore tailing primed with organic matter (OM) amendment and plant colonization. The results demonstrated that microbial OM decomposition dramatically increased DOM richness and average molecular weight, as well as its degree of unsaturation, aromaticity, and oxidation in the tailings. Plant colonization drove molecular shifts of DOM by depleting the unsaturated compounds with a high value of nominal oxidation state of carbon (NOSC), such as tannin-like and carboxyl-rich polycyclic-like compounds. This may be partially related to their sequestration by secondary Fe-Si minerals formed from rhizosphere-driven mineral weathering. Furthermore, the molecular shifts of DOM may have also resulted from plant-regulated microbial community changes, which further influenced DOM molecules through microbial-DOM interactions. These findings contribute to the understanding of DOM biogeochemistry and ecofunctionality in the tailings during early pedogenesis driven by OM input and pioneer plant/microbial colonization, providing an important basis for the development of strategies and technologies toward the eco-engineering of tailings-soil formation.GV971 derived from marine acidic oligosaccharides has been used to cure Alzheimer's disease (AD). However, the molecular mechanism of its inhibition of the conformational transition of amyloid β-proteins (Aβ) is still unclear. Herein, molecular dynamics simulations were used to explore the molecular mechanism of the main GV971 components including DiM, TetraM, HexaM, and OctaM to inhibit the conformational conversion of the Aβ42 monomer. It is found that the GV971 components inhibit the conformational transition from α-helix to β-sheet and the hydrophobic collapse of the Aβ42 monomer. In addition, the binding energy analysis implies that both electrostatic and van der Waals interactions are beneficial to the binding of GV971 components to the Aβ42 monomer. Among them, electrostatic interactions occupy the dominant position. Moreover, the GV971 components mainly interact directly with the charged residues D1, R5, K16, and K28 by forming salt bridges and hydrogen bonds, which specifically bind to the N-terminal region of Aβ42.Primary thyroid lymphoma (PTL) is a rare thyroid gland cancer, with diffuse large B-cell lymphomas (DLBCL) to be extremely rare in children and adolescents. Thus, effective therapy is debatable. We describe a rare case of thyroid DLBCL in an adolescent girl with a history of Hashimoto Thyroiditis (HT), its diagnostic difficulties and the outcome of treatment. A 12- year- old girl with known HT for the last 9 years, was admitted to our department with a right sided painless progressive swelling of the neck. Physical examination and imaging (U/S, CT, PET/CT scan) revealed an enlarged thyroid gland with right side lymphadenopathy and no metastasis. Two FNAs were done showing suspected lymphoblastic lesions for Non-Hodgkin Lymphoma without precise diagnosis. Ultra-sound guided core needle biopsy was finally performed confirming the diagnosis of DLBCL. She was treated according to LMB 96 - group B protocol with no surgical removal of thyroid. The patient responded very well to treatment and 14 months later there is no evidence of relapse or metastases. PTL is an extremely rare cause of thyroid malignancy in children However, it should be considered in the differential diagnosis of a thyroid mass in adolescents presenting with a rapidly enlarging neck mass and a history of HT. It is a treatable condition with a good prognosis even with the aggressive histological subtypes with no need of thyroidectomy.

The introduction of direct-acting antivirals (DAA) has provided us with hope to eliminate hepatitis C virus (HCV) infection as a significant public health problem in the coming years.

Our study aimed to compare the effectiveness and safety between genotype-specific and pangenotypic regimens in GT1b infected patients treated in real-world experience settings.

The patients were selected from 990 HCV infected patients treated with DAA in the Department of Infectious Diseases in Kielce, who initiated the therapy between July, 1 2015 and December, 31 2020.

A total of 795 GT1b infected patients with a median age of 51 years, female predominance (55%), and a 21.1% rate of cirrhosis were included in the analysis. 69.9% of patients were treated with genotype-specific regimens. Those patients were significantly older, with a higher proportion of treatment-experienced individuals and those with advanced liver fibrosis and cirrhosis than patients assigned to pangenotypic regimens. An overall sustained virologic r therapy effectiveness.Background/aim In this study, we aimed to evaluate whether morphological changes in the mesencephalon which were previously described as a diagnostic tool for progressive supranuclear palsy could be associated also with idiopathic normal pressure hydrocephalus. Materials and Methods Consecutive 52 patients with a possible diagnosis of idiopathic normal pressure hydrocephalus (32 female, mean age 73.6 years) and 40 controls (23 female, mean age 72.7 years) with similar demographic characteristics were included the study. The morphologic changes in mesencephalon; hummingbird sign and the vascular compression to mesencephalon were noted. Besides three independent observers evaluated the imaging parameters for idiopathic normal pressure hydrocephalus in Magnetic Resonance Imaging. Inter-observer reliabilities for qualitative and quantitative data were assessed using the Cronbach's Alpha and Intra Class Correlation Coefficient. The correlation of the imaging parameters with each other was evaluated with Pearson correlation. Results Hummingbird sign was found to be significantly more common among patients with idiopathic normal pressure hydrocephalus (p less then 0.0001). A statistically significant correlation was found between hummingbird sign and vascular compression of patients in the study group (p less then 0.0001). A substantial, good and perfect agreement was found between observers at all levels except callosal angle (fair agreement). Conclusion Hummingbird sign can be used to support the diagnosis of idiopathic normal pressure hydrocephalus in addition to other radiological findings. find more A significant correlation between vascular compression and hummingbird sign in the patient group may explain the morphological changes in the mesencephalon that resemble the Hummingbird sign which was previously described for progressive supranuclear palsy.

Phase III trials have demonstrated a significant efficacy and an acceptable safety for pirfenidone in patients having mild to moderate idiopathic pulmonary fibrosis (IPF). Real-life data on the use of pirfenidone 200 mg tablets are limited. This study aimed to investigate the efficacy and safety of pirfenidone 200 mg tablets for the treatment of IPF in a real-life setting.

A retrospective, multicenter study conducted in four university hospitals in XXX between January 2017 and January 2019. Clinical records of patients diagnosed with mild to moderate IPF and receiving pirfenidone (200 mg tablets, total 2400 mg/day) were reviewed retrospectively and consecutively. Pulmonary function measurements including forced vital capacity (FVC%) and diffusing capacity of the lungs for carbon monoxide (DLCO%) were analyzed at baseline and after 6-month of pirfenidone treatment. Descriptive statistics were expressed as mean, standard error or median (minimum-maximum), number and percentage, where appropriate.

The study included 82 patients, of whom 87.8% were males (mean age, 66 years). After 6-month of treatment, 7 patients discontinued the treatment. Of the remaining 75 patients, 71 (94.6%) remained stable, 4 (5.4%) had progressive disease as evident by a decline in the FVC% of at least 10% while on treatment, and 45 (61.3%) had improved cough. At least one adverse event (AE) associated with the treatment was observed in 28 (37.3%) patients.

Pirfenidone 200 mg was effective and well tolerated and associated with relatively mild and manageable AEs in IPF patients.

Pirfenidone 200 mg was effective and well tolerated and associated with relatively mild and manageable AEs in IPF patients.

Giant cell arteritis (GCA) is a large vessel vasculitis that may cause significant morbidity in the elderly population. We aimed to evaluate presentation characteristics, treatment, and outcome in a cohort of patients with GCA diagnosed and followed in a single center.

A retrospective chart review revealed 84 (41 M/43 F) registered patients diagnosed as GCA between 1990 and 2020 patients. Clinical features at presentation and follow-up, radiographical imaging, temporal artery biopsy (TAB), and laboratory findings were retrieved from digital medical records or hard-copy patient files. Of these, 33 patients? follow-up period was less than 12 months; hence, relapses and treatment outcomes were examined in the remaining 51 (60.5%) patients.

A total of 84 patients were included in the cohort. The mean age at diagnosis was 68.4 ± 7.9 years (range 49-85). At presentation, 60 (71.4%) patients had headache, 22 (26.2%) had symptoms compatible with polymyalgia rheumatica (PMR) and 23 (27.4%) had a visual loss. Thrlenging. GCA causes serious morbidities and increased mortality. PET/CT is highly effective in detecting large vessel vasculitis in GCA and could perhaps replace TAB in the future.

This study was conducted to compare the effects of two different `Proprioceptive Neuromuscular Facilitation (PNF)? techniques on knee muscle strength, knee muscular endurance, and proprioception in knee osteoarthritis (KOA) and conventional physiotherapy.

The study included 35 patients aged 47-62 years and diagnosed with stage 1?2 KOA. Using a block randomization method, the patients were divided into three groups as Repeated Stretching Group with repeated stretching (TG) technique (n = 12), Combined Isotonic Contraction Group with combined isotonic contractions (CIC) technique (n = 11), and Conventional Physiotherapy Group (n = 12). PNF was applied to all lower extremity patterns, and all patients were treated 3 days a week for a total of 6 weeks. Muscle strength, muscle endurance, and proprioception were evaluated with Biodex®System Pro3 (Biodex Corp. Shirley NY, USA) before and after the treatment.

Knee extensor muscle strength with the CIC technique showed a marked improvement than other methods and conventional physiotherapy in terms of knee joint position sense evaluated at 60° (p <0.