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Chest computed tomography (CT) imaging is a useful tool that provides in vivo information regarding lung structure. Imaging has contributed to a better understanding of COPD, allowing for the detection of early structural changes and the quantification of extra-pulmonary structures. Novel CT imaging techniques have provided insight into the progression of the main COPD subtypes, such as emphysema and small airway disease. This article serves as a review of new information relevant to COPD imaging. CT abnormalities, such as emphysema and loss of airways, are present even in smokers who do not meet the criteria for COPD and in those with mild-to-moderate disease. Subjects with mild-to-moderate COPD, with the highest loss of airways, also experience the highest decline in lung function. Extra-pulmonary manifestations of COPD, such as right ventricle enlargement and low muscle mass measured on CT, are associated with increased risk for all-cause mortality. CT longitudinal data has also given insight into the progression of COPD. Mechanically affected areas of lung parenchyma adjacent to emphysematous areas are associated with a greater decline in FEV1. Subjects with the greatest percentage of small airway disease, as measured on matched inspiratory-expiratory CT scan, also present with the greatest decline in lung function.

The emergence of COVID-19 pandemic has not only shaken the global health sector, but also almost every other sector, including economic and education sectors. Newspapers are performing a significant role by featuring the news of COVID-19 from its very onset. The temporal fluctuation of COVID-19 related key themes presented in newspaper articles and the findings obtained from them could offer an effective lesson in dealing with future epidemics and pandemics.

This paper intends to develop a pandemic management framework through an automated content analysis of local newspaper coverage of COVID-19 pandemic in Bangladesh. To fulfill the aim, 7,209 newspaper articles are assembled and analyzed from three popular local newspapers named "

, and "

over the period from January 1, 2020 to October 31, 2020.

Twelve key topics are identified origin and outbreak of COVID-19, response of healthcare system, impact on economy, impact on lifestyle, government assistance to the crisis, regular updates, expert opinions, pharmaceutical measures, non-pharmaceutical measures, updates on vaccines, testing facilities, and local unusual activities within the system. Based on the identified topics, their timeline of discussion, and information flow in each topic, a four-stage pandemic management framework is developed for epidemic and pandemic management in future. The stages are preparedness, response, recovery, and mitigation.

This research would provide insights into stage-wise response to any biological hazard and contribute ideas to endure future outbreaks.

This research would provide insights into stage-wise response to any biological hazard and contribute ideas to endure future outbreaks.The mortality rates due to COVID-19 have been found disproportionate globally and are currently being researched. India mortality rate with a population of 1.3 billion people is relatively lowest to other countries with high infection rates. Genetic composition of circulating isolates continues to be a key determinant of virulence and pathogenesis. This study aimed to analyse the extent of divergence between genomes of Indian isolates (n = 2525 as compared to reference Wuhan-1 strain and isolates from countries showing higher fatality rates including France, Italy, Belgium, and the USA. The study also analyses the impact of key mutations on interactions with angiotensin converting enzyme 2 (ACE2) and panel of neutralizing monoclonal antibodies. Using 1,44,605 spike protein sequences, global prevalence of mutations in spike protein was observed. The study suggests that SARS-CoV-2 genomes from India share consensus with global trends with respect to D614G as most prevalent mutational event (81.66% among 2525 Indian isolates). Indian isolates did not reported prevalence of N439K mutation in receptor binding motif (RBM) as compared to global isolates (0.54%). Computational docking and molecular dynamics simulation analysis of N439K mutation with respect to ACE 2 binding and reactivity with RBM targeted antibodies viz., B38, BD23, CB6, P2B-F26 and EY6A suggests that variant have relatively higher affinity with ACE 2 receptor which may support higher infectivity. The study warrants large scale monitoring of Indian isolates as SARS-CoV-2 virus is expected to evolve and mutations may appear in unpredictable way.FGF16 is implicated in the progression of some specific types of cancers, such as embryonic carcinoma, ovarian cancer, and liver cancer. Yet, the function of FGF16 in the development of lung cancer remains largely unexplored. In this study, we present the novel function of FGF16 and the regulation of miR-520b on FGF16 in lung cancer progression. In clinical lung cancer tissues, FGF16 is overexpressed and its high level is negatively associated with the low level of miR-520b. Furthermore, both the transcription and translation levels of FGF16 are restrained by miR-520b in lung cancer cells. For the regulatory mechanism investigation, miR-520b is able to directly bind to the 3'-untranslated region (3'UTR) of FGF16 mRNA, leading to its mRNA cleavage in the cells. Functionally, miR-520b reduces the growth of lung cancer and its inhibitor anti-miR520b is able to promote the growth through competing endogenous miR-520b. Moreover, FGF16 silence using RNA interference is capable of doing great damage to anti-miR-520b-accelerated growth of lung cancer. Thus, our finding indicates that FGF16 is a new target gene of miR-520b in lung cancer. For lung cancer, FGF16 may serve as a novel biomarker and miR-520b/FGF16 may be useful in clinical treatment.The aim of this study was to assess the psychological impact among healthcare workers who stand in the frontline of the SARS-CoV-2 crisis and to compare it with the rest of healthcare professionals, by means of a systematic review of Western publications. The systematic review was carried out in PubMed, Scopus and Web of Science databases and 12 descriptive studies were reviewed. The European and American quantitative studies reported moderate and high levels of stress, anxiety, depression, sleep disturbance and burnout, with diverse coping strategies and more frequent and intense symptoms among women and nurses, without conclusive results by age. In the first line of assistance the psychological impact was greater than in the rest of the health professionals and in the Asian area. It is necessary to go deeper into the emotional experiences and professional needs for emotional support in order to design effective interventions for protection and help.Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non-hepatocyte delivery at clinical doses remains difficult. We noted that LNPs have historically been formulated with phospholipids containing unconstrained alkyl tails. Based on evidence that constrained adamantyl groups have unique properties that can improve small molecule drug delivery, we hypothesized that a phospholipid containing an adamantyl group would facilitate mRNA delivery in vivo. We quantified how 109 LNPs containing "constrained phospholipids" delivered mRNA to 16 cell types in mice, then using a DNA barcoding-based analytical pipeline, related phospholipid structure to in vivo delivery. By analyzing delivery mediated by constrained phospholipids, we identified a novel LNP that delivers mRNA to immune cells at 0.5 mg/kg. Unlike many previous LNPs, these (a) did not preferentially target hepatocytes and (b) delivered mRNA to immune cells without targeting ligands. These data suggest constrained phospholipids may be useful LNP components.The role of technology and importance of access to high-speed broadband has become glaringly obvious during the COVID-19 pandemic. High-speed Internet is a tool people rely upon to conduct the daily business of their life and interact with each other, the economy, and government. However, millions of people in the USA still have no home access to high-speed Internet. Low-income, people of color, older, Native Americans, and rural residents in particular are on the wrong side of the digital divide. This structural reality perpetuates social, economic, and political disparities. Consistent with a social work human rights approach, the United Nations General Assembly declared access to the Internet a basic human right in 2016. This calls upon social workers to engage in advocacy efforts to advance policy and programs to alleviate the digital divide. In this article, we examine the digital divide in the USA and discuss why it is a social justice and human rights issue. We provide a policy context and recent examples of state or local policy initiatives to reduce the digital divide. Prominent among them is California's Internet for All Now Act. Teniposide nmr We also identify and share promising practices and advocacy tools being used in the field that provide guidance to community practitioners as they engage in work at state and local levels aimed at closing the digital divide.The question of human mobility is inextricably tied to the COVID-19 pandemic that started in late 2019 and whose effects continue to unfold. Human mobility-especially with global advances in transportation and interconnectedness-is an important factor in the spread of the pandemic. Yet, the impact of the COVID-19 pandemic on the millions of people forced to migrate for safety and economic reasons has received little attention. In this article, we provide an overview of human rights challenges that forced migrants currently face during this pandemic. While we do not address all dimensions of the impact COVID-19, we highlight several troubling situations that have emerged for refugees and asylum seekers. These include entry restrictions into some countries that had formerly welcomed asylum seekers, overt and covert forms of exclusion of migrants from labor markets due to rising unemployment and economic hardship, and implementing new deportation policies, as well as new exclusionary policies for immigrants who would have been authorized to work in past. Without concerted efforts to amplify solidarity with all forced migrants and ensure their human rights, discriminatory and restrictionist policies enacted in the Global North over the past decade will become entrenched. As a result, fewer refugees and asylum seekers will be accorded protection and continue to face violence and persecution in their home countries.Nigeria agriculture, food security and dietary intake have not been exempted from the disruptions in countless sectors around the world due to the outbreak of COVID-19. The country first experienced the outbreak on February 27, 2020, and the experience since then has shown negative effects not only on the socioeconomic conditions but also on agriculture, food security and dietary intake. Long term in-depth analysis of the effects of this pandemic on food security and dietary intake using quantitative data is still very difficult due to paucity of data and the great level of the improbability of the trajectory of the spread of the Virus. This study is a rapid assessment of the short and long-term potential effects of the disease. It relied on a review of situation reports especially by the Nigeria Centre of Disease Control and other reports around the world on COVID-19, personal observations, and public opinion via mobile telephone survey of Lagos and Oyo States, Nigeria. Findings show that food demand and supply shocks caused by COVID-19 outbreak affect agriculture, food and dietary intake negatively through COVID-19 policies.