Mortensenslaughter2254

OBJECTIVES Fatigue is common among people with inflammatory arthritis but is hard to manage. The aim of this study was to investigate how daily fluctuations in psychological variables correspond with changes in fatigue-related disability in the daily lives of people with inflammatory arthritis to identify factors to target in psychological interventions and routine clinical practice. METHODS A cohort of 143 patients with rheumatoid arthritis (n=97) or ankylosing spondylitis (n=46) participated in a 10-day online diary study. Each evening participants completed a diary questionnaire assessing their fatigue, pain, fatigue-related disability, and four components of psychological flexibility (valued activity, mindfulness, cognitive fusion, and fatigue avoidance). RESULTS On days when participants were more engaged in valued activities or more mindful, they reported less disability due to fatigue, even when controlling for levels of fatigue and pain that day. The daily psychological flexibility variables explained a total of 15.6% of the variance in daily fatigue-related disability. CONCLUSION Psychological flexibility variables are directly associated with fatigue-related disability in the daily lives of inflammatory arthritis patients. Further research is needed to investigate whether interventions that target psychological flexibility are effective at reducing fatigue-related disability. This article is protected by copyright. All rights reserved.In rice, the Waxy (Wx) gene encoding GBSSI (granule-bound starch synthase I) controls amylose synthesis in endosperm and is the primary factor influencing grain eating and cooking quality (ECQ). This article is protected by copyright. All rights reserved.Cost-effective and high-performance electrocatalysts for oxygen reduction reactions are needed for many energy storage and conversion devices. Here, we demonstrate that whey powder, a major by-product in the dairy industry, can be used as a sustainable precursor to produce heteroatom doped carbon electrocatalysts for ORR. Rich N and S compounds in whey powders can generate abundant catalytic active sites. However, these sites are not easily accessible by reactants in ORR. A dual-template method was used to create a hierarchical and interconnected porous structure with micropores created by ZnCl 2 and large mesopores generated by fumed SiO 2 particles. At the optimum mass ratio of whey power ZnCl 2 SiO 2 at 130.8, the resulting carbon material has a large specific surface area close to 2000 m 2 g -1 , containing 4.6 at.% of N with 50.4% as pyridinic N. This carbon material shows superior catalytic activity for ORR, with an electron transfer number of 3.88 and a large kinetic limiting current density of 45.40 mA cm -2 . They were employed as ORR catalysts to assemble primary zinc-air batteries, which deliver a power density of 84.1 mW cm -2 and a specific capacity of 779.5 mAh g -1 , outperforming batteries constructed using the commercial Pt/C catalyst. Our findings open new opportunities to use an abundant biomaterial, whey powder, to create high-value-added carbon electrocatalyst for emerging energy applications. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Variants of the highly active [NiFeSe] hydrogenase from D. vulgaris Hildenborough exhibiting enhanced O2 tolerance were used as H2 oxidation catalysts in H2/O2 biofuel cells. Two [NiFeSe] variants were electrically wired by means of low-potential viologen-modified redox polymers and evaluated with respect to H2 oxidation and stabi-lity against O2 in the immobilized state. Both variants show maximum current densities of (450 ± 84) µA cm-2 for G491A and (476 ± 172) µA cm-2 for the variant G941S on glassy carbon electrodes and a higher O2 tolerance as compared to the wild type, in addition the polymer protects the enzyme from O2 damage and high potential inactivation establishing a triple protection for the bioanode. The use of gas diffu-sion bioanodes provided current densities for H2 oxidation of up to 6.3 mA cm-2. Combination of the gas diffusion bioanode with a bilirubin oxidase based gas diffusion O2 reducing biocathode in a membrane-free biofuel cell and under anode limiting conditions showed unprece-dented benchmark power densities of 4.4 mW cm-2 at 0.7 V and an open circuit voltage of 1.14 V even at moderate catalyst loadings outperforming previously reported system obtained with the [NiFeSe] wild type and the [NiFe] hydrogenase from D. vulgaris Miyazaki F. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The increased risks to children born preterm have been well delineated. Not only are they at risk for neonatal complications, such as necrotizing enterocolitis and respiratory distress syndrome, but they are at significantly increased risk for long-term complications such as neurodevelopmental impairment. Indeed, prematurity is a primary etiologic factor for cerebral palsy (CP). This article is protected by copyright. All rights reserved.Randomised trials remain the gold standard for evaluation of effectiveness of medical interventions. However, they are expensive, time consuming and demand huge efforts from participants, researchers and the clinical services that facilitate them. Even when trials are successfully completed, peer reviewers often find them wanting. One of the most common criticisms is a 'lack of power' to tackle clinically important outcomes. Why is this happening time and again? This article is protected by copyright. All rights reserved.OBJECTIVE To report mode of delivery and immediate neonatal outcome in COVID-19 infected women. DESIGN This is a retrospective study. SETTING Twelve hospitals in northern Italy. PARTICIPANTS Pregnant women with COVID-19 confirmed infection who delivered. EXPOSURE COVID 19 infection in pregnancy. METHODS SARS-CoV-2 infected women who were admitted and delivered during the period 1-20 march 2020 were eligible. Data were collected from the clinical records using a standardized questionnaire on maternal general characteristics, any medical or obstetric co-morbidity, course of pregnancy, clinical signs and symptoms, treatment of COVID 19 infection, mode of delivery, neonatal data and breastfeeding MAIN OUTCOME AND MEASURE Data on mode of delivery and neonatal outcome RESULTS 42 women with COVID-19 delivered at the participating centres 24(57,1%, 95% CI= 41,0-72,3) delivered vaginally. An elective cesarean section was performed in 18/42 (42,9%, 95%CI 27,7-59,0) cases in 8 cases the indication was unrelated to COVID-19 infection. Pneumonia was diagnosed in 19/42(45,2%, 95%CI 29,8-61,3) cases of these 7/19(36,8%,95CI 16,3-61,6) required oxygen support and 4/19(21,1%,95%CI=6,1-45,6) were admitted to a critical care unit. Two women with COVID-19 breastfed without a mask because infection was diagnosed in the post-partum period their new-borns tested positive for SARS-Cov-2 infection. In one case a new-born had a positive test after a vaginal operative delivery. CONCLUSIONS Although post-partum infection cannot be excluded with 100% certainty, these findings suggest that vaginal delivery is associated with a low risk of intrapartum SARS-Cov-2 transmission to the new-born. HS148 cost This article is protected by copyright. All rights reserved.Although accumulating evidence had revealed that NFAT1 has oncogenic characteristics, the role of this molecule in melanoma cells remains unclear. Previous studies proved that CD147 plays a crucial function in melanoma cell metastasis and invasion through matrix metalloproteinase 9 (MMP-9) expression; however, the details of how CD147 regulates MMP-9 expression remain elusive. In this study, we demonstrated that CD147 and NFAT1 are overexpressed in the tissues of patients with primary and metastatic melanoma, which has shown a positive correlation. Further, we observed that CD147 regulates NFAT1 activation through the [Ca2+ ]i-calcineurin pathway. Knock down of NFAT1 significantly suppresses melanoma metastasis, and we demonstrated that CD147 affects melanoma metastasis in an NFAT1-dependent manner. Moreover, we verified that NFAT1 directly binds to MMP-9 promoter. Inhibition of CD147 expression significantly abrogates MMP-9 promoter luciferase gene reporter activity as well as NFAT1 association with MMP-9 promoter. Taken together, this study demonstrated that CD147 affects MMP-9 expression through regulating NFAT1 activity and provided a novel mechanism by which NFAT1 contributes to melanoma metastasis through the regulation of MMP-9. This article is protected by copyright. All rights reserved.This work presents a CE methodology for the enantiodetermination of cathinones in urine employing a liquid-liquid extraction sample pretreatment. The cathinones were enantioseparated by adding a mixture of 8 mM 2-hydroxypropyl β-cyclodextrin and 5 mM β-cyclodextrin to the background electrolyte, which consists of 70 mM of monosodium phosphate aqueous solution at pH 2.5. Field-amplified sample injection was used as preconcentration strategy to improve the sensitivity. We studied various parameters that affect this stacking strategy, in particular, the sample solvent and its pH, the presence/absence of a low conductivity solvent plug introduced before the sample injection, the nature and volume of this plug and the voltage and time of the electrokinetic injection of the sample. The optimum conditions were achieved by injecting a plug of isopropanolH2 O 50/50 at 50 mbar for 5 s prior to the electrokinetic injection of the sample prepared in an aqueous solution of HCl 10-6 M. The sensitivity enhancement factors were from 562 to 601 in terms of peak area and from 444 to 472 in terms of peak height. The method was validated by analysing spiked urine samples, obtaining a linear range of 25 to 1000 ng/mL and LODs ranging from 15 to 45 ng/mL. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Adaptor protein containing a PH domain, PTB domain and leucine zipper motif 1 (APPL1) plays a central role as the main contributing factor in the adiponectin and insulin signaling. This review aims to discuss previous and recent findings concerning the role of APPL1 in the polycystic ovary syndrome (PCOS) patients with conclusions regarding more efficient therapeutic approaches. A literature review was performed in PubMed, Web of Science, ScienceDirect, Scopus, and Google Scholar from August 1999 to May 2020. This study reveals that APPL1 has a key role in adiponectin, insulin, and follicle-stimulating hormone signaling pathways occurring within the ovaries. Recent studies in mouse model systems have indicated that APPL1 can prevent diabetes, endothelial disorders, and insulin resistance. In contrast, APPL1 deficiency can lead to the metabolic and vascular disorders. APPL1 due to its potential roles in different signaling pathways might be suggested as a novel diagnostic and therapeutic option for prediction of ovarian dysfunctions and treatment of reproductive disorders, especially PCOS. © 2020 International Federation for Cell Biology.OBJECTIVE Women's levels of resilience and attitudes towards perineal lacerations vary greatly. Some women see them as part of the birthing process, while others react with anger, depressed mood or even self-harm thoughts. A previous study has reported increased risk of postpartum depressive (PPD) symptoms in women with severe perineal lacerations. The aim of this study was to assess the association between severe obstetric perineal lacerations and PPD. A secondary objective was to assess this association among women with low resilience. DESIGN Nested cohort study. SETTING Uppsala, Sweden. SAMPLE Vaginally delivered women with singleton pregnancies (n = 2,990). METHODS The main exposure was obstetric perineal lacerations. Resilience was assessed in gestational week 32 using the Swedish version of the Sense of Coherence Scale (SOC-29). A digital acyclic graph (DAG) was used to identify possible confounders and mediators. Logistic regression was used to estimate odds ratios and 95% confidence intervals. A sub-analysis was run after excluding women with normal or high resilience.