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Coronavirus disease 2019 (COVID-19) has currently become a major global public health problem. The prevalence of COVID-19 has increased rapidly worldwide. Because there is no effective COVID-19 vaccine available yet, it is increasingly important to understand the average incubation period of severe acute respiratory syndrome novel coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, to design appropriate preventive and control strategies.

This systematic review and meta-analysis was designed to estimate the pooled average incubation period of SARS-CoV-2, the virus that causes COVID-19.

We conducted a systematic electronic web-based search of online databases, including PubMed, Google Scholar, Embase, and the World Health Organization Hinari portal. We included peer-reviewed research studies written in the English language on the incubation period of SARS-CoV-2 using pre-defined quality and inclusion criteria. STATA version 15 statistical software was used to analyze the data. Joanna Briggs Instits should consider this average incubation period when designing optimal prevention and control strategies for SARS-CoV-2. (

. 2020; 81XXX-XXX).

The pooled average incubation period of SARS-CoV-2 was about 6 days. The longest incubation period was observed in China. Global health initiatives as well as local health planners should consider this average incubation period when designing optimal prevention and control strategies for SARS-CoV-2. (Curr Ther Res Clin Exp. 2020; 81XXX-XXX).Heterogeneously catalyzed epoxidation of vegetable oils by hydrogen peroxide represents a greener route for the production of epoxides and a thermally safer reaction route compared to the classical Prileschajew epoxidation approach. The epoxidation kinetics of the heterogeneous system formed by aluminium oxide catalyst, hydrogen peroxide and methyl oleate as a model compound was studied with semibatch experiments in laboratory scale. It was found that semibatch operation improved the performance significantly compared to classical batch operation, a low and constant volumetric flowrate of hydrogen peroxide increased the final oxirane yield considerably. A semibatch reactor model and a kinetic model were developed, featuring the reaction temperature, the reactant molar ratio, the catalyst loading and the mass flow rate as the most significant experimental parameters. The mathematical model was able to well describe the experimental data. The approach can be applied to other liquid-solid catalyst systems in future in order to optimize the semibatch operation policy for complex reaction systems.We examine the impact of COVID-19 on the federal budget outlook. We find substantial but temporary effects on spending and revenues, with more moderate but permanent effects on the long-term projections. We project that the debt-to-GDP ratio, currently 98%, will rise to 190% in 2050 under current law, compared to a CBO pre-COVID projection of 180%. Sharply lower interest rates projected for the next dozen years help moderate future debt accumulation. Under a "current policy" projection that allows temporary tax provisions-such as those in the Tax Cut and Jobs Act of 2017-to be made permanent, the debt-to-GDP ratio would rise to 222% by 2050 and would continuing rising thereafter. The long-term projections are sensitive to interest rates. We discuss several aspects of these results, including how the current episode compares to past debt changes, the role of historically low interest rates, and the role of recent Federal Reserve Board policies and actions. Because of the macro-stabilization effects of fiscal tightening, and because low interest rates create "breathing room" for fiscal policy, we do not see the large, short-run debt accumulation resulting from the current pandemic as necessitating any immediate offsetting response. But the long-term projections show that significant fiscal imbalances remain and will eventually require attention.The European Union is one of the most important markets for the trafficking of endangered species and a major transit point for illegal wildlife trade. #link# The latter is not only one of the most important anthropogenic drivers of biodiversity loss, it also represents a growing risk for public health. Indeed, wildlife trade exposes humans to a plethora of severe emerging infectious diseases, some of which have contributed to the most dramatic global pandemics humankind has endured. Illegal wildlife trade is often considered as a problem of developing countries but it is first and foremost an international global business with a trade flow from developing to developed countries. The devastating effects of the ongoing SARS-CoV-2 outbreak should thus be an unassailable argument for European decision makers to change paradigm. Rather than deploying efforts and money to combat novel pathogens, mitigating the risk of spreading emerging infectious diseases should be addressed and be part of any sustainable socioeconomic development plan. Stricter control procedures at borders and policies should be enforced. Additionally, strengthening research in wildlife forensic science and developing a network of forensic laboratories should be the cornerstone of the European Union plan to tackle the illegal wildlife trade. Such proactive approach, that should further figure in the EU-Wildlife Action Plan, could produce a win-win situation the curb of illegal wildlife trade would subsequently diminish the likelihood of importing new zoonotic diseases in the European Union.Large spaces, circular in plan, can be preferred by architects to design large auditoria, even though they can cause acoustical singularities such as focusing and whispering gallery. In large auditoria for multipurpose functions are becoming a common request to use the space for different activities such as conferences, concerts of classical and amplified music, shows, etc. and the necessity to find architectural solutions in order to consider the variable acoustic demands according to different possible layouts, are growing. link2 In this paper, as a case study, architectural acoustic design approaches and solutions for a circular auditorium are presented. The case study was made in "Le Serre" hall for 1000 people, in the Villa Erba Convention Center, located in Cernobbio (Italy), in which different combinations of movable architectural elements are developed to create a multipurpose space. A geometrical acoustic analyses are included, followed by the description of different methods to avoid focusing and whispering. Room acoustics procedures and implementations of computer simulation techniques are developed.[This corrects the article DOI 10.1016/j.banm.2020.04.007.].Antipsychotic drugs are one of the oldest drugs that can change the brain activity. These drugs are mainly used in schizophrenia and the first drug that was judged as efficacious in the treatment of psychosis has been chlorpromazine. This is a decade later that it has been shown that these drugs were antagonists at the dopamine transmission by blocking the dopamine D2/D3 receptors. Several other pharmacological targets have been tested during the last decades as glutamatergic, serotoninergic, cholinergic and neuropeptidergic agents but none has been shown to improve symptoms of schizophrenia. Three main issues could explain this failure the exact causes of schizophrenia is still unknown, we still used the idea that one drug could improve all the symptoms of schizophrenia and it is clear that the group of schizophrenics disease could be different disease with different causes. We propose to review the different drugs that have been tested and we will discuss why the most recent genetic studies could help us to propose new pharmacological targets to treat schizophrenia.Unfolded protein response (UPR) is a conserved adaptive response that tries to restore protein homeostasis after endoplasmic reticulum (ER) stress. Recent studies highlighted the role of UPR in acute leukemias and UPR targeting has been suggested as a therapeutic approach. Aberrant Notch signaling is a common feature of T-cell acute lymphoblastic leukemia (T-ALL), as downregulation of Notch activity negatively affects T-ALL cell survival, leading to the employment of Notch inhibitors in T-ALL therapy. Here we demonstrate that Notch3 is able to sustain UPR in T-ALL cells, as Notch3 silencing favored a Bip-dependent IRE1α inactivation under ER stress conditions, leading to increased apoptosis via upregulation of the ER stress cell death mediator CHOP. By using Juglone, GS-5734 occurring naphthoquinone acting as an anticancer agent, to decrease Notch3 expression and induce ER stress, we observed an increased ER stress-associated apoptosis. Altogether our results suggest that Notch3 inhibition may prevent leukemia cells from engaging a functional UPR needed to compensate the Juglone-mediated ER proteotoxic stress. Notably, in vivo administration of Juglone to human T-ALL xenotransplant models significantly reduced tumor growth, finally fostering the exploitation of Juglone-dependent Notch3 inhibition to perturb the ER stress/UPR signaling in Notch3-dependent T-ALL subsets.Transition-metal-carbonyl complexes are common organometallic reagents that feature metal-CO bonds. These complexes have proven to be powerful catalysts for various applications. By contrast, silicon-carbonyl complexes, organosilicon reagents poised to be eco-friendly alternatives for transition-metal carbonyls, have remained largely elusive. They have mostly been explored theoretically and/or through low-temperature matrix isolation studies, but their instability had typically precluded isolation under ambient conditions. Here we present the synthesis, isolation and full characterization of stable silyl-substituted silicon-carbonyl complexes, along with bonding analysis. Initial reactivity investigations showed examples of CO liberation, which could be induced either thermally or photochemically, as well as substitution and functionalization of the CO moiety. link3 Importantly, the complexes exhibit strong Si-CO bonding, with CO→Si σ-donation and Si→CO π-backbonding, which is reminiscent of transition-metal carbonyls. This similarity between the abundant semi-metal silicon and rare transition metals may provide new opportunities for the development of silicon-based catalysis.An urgent medical need to develop novel treatment strategies for patients with pancreatic ductal adenocarcinoma (PDAC) exists. However, despite various efforts in the histopathological and molecular subtyping of PDAC, novel targeted or specific therapies have not been established. Posttranslational modifications (PTMs) with ubiquitin-like proteins, including small ubiquitin-like modifiers (SUMOs), mediate numerous processes that can contribute to the fitness and survival of cancer cells. The contribution of SUMOylation to transcriptional control, DNA repair pathways, mitotic progression, and oncogenic signalling has been described. Here we review functions of the SUMO pathway in PDAC, with a special focus on its connection to an aggressive subtype of the disease characterised by high MYC activity, and discuss SUMOylation inhibitors under development for precise PDAC therapies.