Jensbyvendelbo7532

This new approach has potential application in the hydrometallurgical leaching and purification of NMs from ores, spent catalysts, and electronic and nano-wastes.The manufacturing of both metals and polymer materials strongly relies on melt processing at relatively high temperatures which needs complex shaping-cooling equipment, long molding time, and considerable energy consumption. Reducing the processing temperature to achieve room-temperature malleability is heavily desired for low-carbon demands but continues to be a great challenge. Here, we demonstrate a noncovalent assembly strategy to fabricate room-temperature malleable composites embedded by liquid metals with excellent toughness (105.88 MJ m-3, higher than most traditional plastics and metallic aluminum) and strong mechanical strength (35.49 MPa). The dissociation-reconstruction of supramolecular bonding interactions between assembled nanoparticles and polymer matrix allow the malleable composite with two interchangeable supramolecular states to achieve programming at room temperature stimulated by water vapor and give it self-healing ability (self-healing efficiency of ∼100%; the healed sample can lift about 52,300 times its own weight). Furthermore, the composite also exhibits metallic luster and prospective application in thermal dissipation. This strategy might be an efficient way for the development of a method for strong and tough materials structurally designed to achieve programming at moderate conditions.In previous studies, AuAg colloidal nanostar formulations were developed with the two-fold aim of producing optimized surface-enhanced Raman spectroscopy (SERS) substrates and investigating the nature of the capping process itself. Findings demonstrated that the nanoparticle metals are alloyed and neutral, and capping by stabilizers occurs via chemisorption. This study utilizes citrate as the model stabilizer and investigates the mechanistic aspects of its interaction with mono- (Au20) and bimetallic (Au19Ag) surfaces by density functional theory (DFT) calculations. Citrate was modeled according to the colloid's pH and surrounded by a water and sodium first solvation shell. A population of stable cluster-citrate structures was obtained, and energies were refined at the uB3LYP//LANL2TZ(f)/cc-pVTZ level of theory. Solvation was accounted for both explicitly and implicitly by the application of the continuum model SMD. Results indicate that both direct binding and binding by water proxy through the charge-transfer complex formation are thermodynamically favorable. Water participation in citrate adsorption is supported by the adsorption behavior observed experimentally and the comparison between experimental and DFT-simulated IR spectra. Vibrational mode analysis suggests the possible presence of water within a crystal in dried nanostar residues. All ΔGads(aq) indicate a weak chemisorptive process, leading to the hypothesis that citrate could be displaced by analytes during SERS measurements.Ketene (CH2 =C=O) has been postulated as a key intermediate for the first olefin production in the zeolite-catalyzed chemistry of methanol-to-olefins (MTO) and syngas-to-olefins (STO) processes. The reaction mechanism remains elusive, because the short-lived ethenone ketene and its derivatives are difficult to detect, which is further complicated by the low expected ketene concentration. We report on the experimental detection of methylketene (CH3 -CH=C=O) formed by the methylation of ketene on HZSM-5 via operando synchrotron photoelectron photoion coincidence (PEPICO) spectroscopy. Ketene is produced in situ from methyl acetate. The observation of methylketene as the ethylene precursor evidences a computationally predicted ketene-to-ethylene route proceeding via a methylketene intermediate followed by decarbonylation.Gold nanoparticle-based point-of-care tests (POCT) are one of the most widely used diagnostic tools for SARS-CoV-2 screening. However, the limitation of their insufficient sensitivity often leads to false negative results in early disease diagnostics. The ongoing pandemic of COVID-19 makes diagnostic tools that are more accurate, sensitive, simple, and affordable in high demand. In this work, we develop a platinum-decorated gold nanoparticle (Au@Pt NP)-based microfluidic chip immunoassay with a sensitivity surpassing that of paper-based detection of nucleocapsid (N) protein, one of the most conserved biomarkers of COVID-19. The synthesized Au@Pt NPs show high stability and catalytic activity in complex environments. The catalytic amplification of Au@Pt NPs enables naked-eye detection of N protein in the low femtogram range (ca. 0.1 pg/mL) and the detection of throat swab samples in under 40 min. This microfluidic chip immunoassay is easy for operation and readout without instrument assistance, making it more suitable for on-site detection and future pathogen surveillance.Anaplastic thyroid carcinoma is an infrequent, but aggressive fatal subtype of thyroid cancer. The osteoclastic variant of anaplastic carcinoma is a rare subtype of anaplastic carcinoma with rare cases reported in the literature. Molecular targeted therapies have emerged for the anaplastic carcinoma, necessitating accurate pathologic diagnosis with additional ancillary testing for directing clinical management. We present here the cytological diagnosis of an anaplastic thyroid carcinoma-osteoclastic variant on fine-needle aspiration (FNA), with emphasis on the novelty of utilizing the least invasive procedure (aspiration cytology) for rendering pathological diagnosis as well as identifying potential prognostic markers for targeted immunotherapy.Spatial resolution improvement has been keenly sought recently in the perovskite-based scintillation community. Here, micrometer resolution (∼2.0 μm) was achieved by using an X-ray imaging screen of self-assembled perovskite nanosheets. The assembly behavior of nanosheets was applicable to many substrates, including glass, metal, and polymer surfaces. The use of a polymer substrate not only eliminated the parasite absorption of X-ray but also enabled a flexible screen with robust bending stability. The assembly behavior, on the other hand, provided vicinity for an efficient energy transfer between nanosheets of varied thicknesses, as evidenced by both transient absorption and photoluminescence lifetime measurements. Importantly, the ensuing large Stokes shift (∼316 meV) significantly mitigated the reabsorption issue, leading to a comparable light yield to LYSO/Ce crystals. With the aid of the synchrotron-based collimated X-ray beam, the fine structure of two-dimensional objects, such as microchips, was clearly visualized with the flexible scintillation screen. Furthermore, those challenging biological samples were also scanned by phase-contrast imaging, whereby a three-dimensional reconstruction was obtained successfully. Despite the labile nature of the perovskite screen, this work represents the state-of-the-art spatial resolution for perovskite scintillation.Spindle cell/sclerosing rhabdomyosarcoma (RMS), characterized by MYOD1 (L122R) mutation in a subset of cases is a newly described subtype of RMS. Presently, there is no documentation of cytomorphological features, especially of sclerosing RMS. Case 1 A 24-year-old male presented with pain and swelling in his wrist for a one-year duration. MRI revealed a well-defined soft tissue lesion measuring 5.3 cm, encasing the lower end of the ulna. Fine-needle aspiration cytology (FNAC) smears revealed clusters of tumor cells with round to oval to spindle-shaped nuclei, scant to moderate amount of cytoplasm with the wisps of the metachromatic stroma. Histopathological examination revealed a malignant tumor comprising cells with polygonal to spindle-shaped nuclei, arranged in a sclerotic stroma. Immunohistochemically, the tumor cells were positive for desmin, myogenin, and MYOD1. A diagnosis of sclerosing RMS was offered. Furthermore, the tumor revealed MYOD1 (L122R) mutation. Case 2 A 43-year-old male presented with a 4-month history of "nasal stuffiness" and pressure. Imaging revealed a poorly defined infiltrative lesion in his nasal cavity. FNAC smears revealed loose and tightly cohesive clusters of malignant cells with oval to spindle-shaped nuclei, a moderate amount of ill-defined bluish to finely vacuolated cytoplasm, and focal streak artifact with interspersed stromal fragments. Histopathological examination revealed a malignant tumor composed of oval to spindle-shaped nuclei, embedded in a variably hyalinized stroma. Immunohistochemically, the tumor cells were positive for desmin, and myogenin. Diagnosis of spindle cell/sclerosing RMS was offered. The present study constitutes one of the first documentation of cytomorphological features of two rare cases of spindle cell/sclerosing RMS. The differential diagnoses and treatment-related implications are presented.Mechanochromic hydrogels, which can switch their color in response to the applied external force, have shown great potential in stress visualization and damage indication. However, the kinds of colors in the reported mechanochromic hydrogels are limited. It is challenging to develop mechanochromic hydrogels with new kinds of color changes. Herein, a kind of mechanochromic double network (DN) hydrogel is reported based on the hybrid phenol-rhodamine mechanophore. The hydrogels turn into orange color with an emission wavelength of around 566/574 nm in response to tensile and compressive stress. The DN hydrogels show great reversibility. The color of DN hydrogels vanishes slowly after releasing the stress. The stress sensitivity can be tailored by the crosslinking density and the mechanophore concentration of the first network. In addition, the influence of the pH on the mechanochromic properties of DN hydrogels is also studied. This study provides an insightful study in tuning the stress sensitivity in the mechanochromic hydrogel, which will be beneficial for the development of mechanochromic materials.Cancer cell-derived Col1 homotrimers regulate the PDAC microbiome and block T-cell infiltration.AKT inhibits the metabolic enzyme PANK4 to promote the de novo synthesis of coenzyme A (CoA).Survival benefit and a manageable safety profile were observed with G47Δ in patients with glioblastoma.Patients on ICI therapy rarely experience life-threatening myocarditis, but little is currently known about the risk of other major adverse cardiac events (MACE) in this population. A retrospective study finds that 10% of patients, mostly with advanced cancers, experience MACE, with those with preexisting poor cardiovascular health being at greater risk.Addition of genetic risk score to prediction models improves obesity risk prediction in adult survivors of childhood cancer.

As part of global change, climate warming and pollinator decline are expected to affect plant phenology and plant-pollinator interactions. This paper aims at characterizing rapid evolution of life history traits and floral traits over two decades in the wild pansy (Viola arvensis), a common weed in agrosystems.

We used a resurrection ecology approach with genotypes sampled in 1991 and 2012 from a population in Burgundy (France). The species has a mixed mating system (hereafter mixed selfer) and presents a floral polymorphism. https://www.selleckchem.com/products/p7c3.html To correct for maternal effects, we measured plant traits in the second generation in a common garden (after a refreshing generation) to characterize plant evolution during the two decades. In addition, historical population selfing rates in 1991 and 2012 were inferred from microsatellites markers through heterozygote deficiency and identity disequilibrium.

Phenotypic data revealed a significant advance in flowering date, reduced flower sizes and a higher propensity of plants to set seed by autonomous selfing.