Cormiercoleman8115

We will utilize Stata and Revman for systematic review and meta-analysis and analysis of direct and indirect evidence.

Based on current evidence, this study will elucidate the rationale for the utilization of TCM in PMS/PMDD treatment.

Conclusions from this study will inform about the effectiveness and safety of TCM in PMS/PMDD management.

CRD42020192822.

Since all data utilized in this systematic review and meta-analysis are published, ethical approval is not needed. Additionally, in the trial of the review process, all data will be evaluated anonymously.

Since all data utilized in this systematic review and meta-analysis are published, ethical approval is not needed. Additionally, in the trial of the review process, all data will be evaluated anonymously.

What affects the efficacy of alendronate for prevention of glucocorticoid-induced (GI) fractures remains unclear. We aimed to explore the factors affecting alendronate's efficacy, and further identify subgroup effects of alendronate in preventing GI fractures.

We searched 3 databases. Random-effects meta-analysis was conducted to synthesize risk ratio (RR) and 95% confidence interval (CI) for each endpoint. Meta-regression analysis was used to explore sources of heterogeneity, and subgroup analysis was used to address heterogeneity and evaluate subgroup effects. We detected publication bias using funnel plots and Egger tests.

We included 13 papers from 12 unique studies involving 46431 participants. Glucocorticoid (GC) dosage (P = .053) and proportion of previous vertebral fracture (PVF) (P = .047) were probably 2 sources of heterogeneity in meta-analysis for vertebral fractures, while GC duration (P = .020) was probably 1 for nonvertebral fractures. Alendronate reduced vertebral fractures in the high dosage subgroup (RR 0.61, 95% CI 0.44-0.86), but didn't in the low dosage subgroup (RR 1.56, 95% CI 0.20-12.02). Alendronate reduced vertebral fractures (RR 0.53, 95% CI 0.40-0.68) in the subgroup of PVF proportion <5%, but didn't (RR 0.76, 95% CI 0.42-1.37) in the subgroup of this proportion ≥5%. Alendronate reduced nonvertebral and hip fractures, whether in primary or in secondary prevention subgroup.

The findings in our study support that alendronate is used for the primary and secondary prevention of GI fractures, but do not support that alendronate is recommended as a first-line agent for patients receiving a low dose of GCs or patients with PVF.

The findings in our study support that alendronate is used for the primary and secondary prevention of GI fractures, but do not support that alendronate is recommended as a first-line agent for patients receiving a low dose of GCs or patients with PVF.The distribution characteristics of ABO and RhD blood groups in the world were different and the data were limited. The aim was to investigate the distribution characteristics of ABO and RhD blood groups in Chongqing, and to provide scientific-effective data for a more reasonable blood collection program. We retrospectively analyzed 795 698 blood donors who had donated blood from 2014 to 2019 at the Chongqing Blood Center. The data on ABO and RhD blood groups were extracted based on blood management system. We used percentages to describe the extraction of data on blood donors by gender, age, and nationality. The data on the distribution of ABO (A, B, AB and O) and RhD (RhD-Positive and RhD-Negative) blood groups were reported also in percentages. Of those, 427 516 (53.73%) were males and 368 182 (46.27%) were females. Among all the blood donors, 321 916 (40.46%) were under the age of 25, followed by 26-35 years age group (22.65%), 36-45 years age group (18.95%), 46-55 years age group (16.98%) and 56-60 years age group (0.96%). There were 755439 (94.94%) of the blood donors who were of the Han nationality. The distribution of blood groups O, A, B and AB were 35.54%, 31.90%, 24.14% and 8.42%, respectively. The distributions of RhD-Negative group was found in 4362 (0.55%) blood donors. The distribution characteristics of the ABO and RhD blood group should be considered when improving blood collection program in Chongqing.

Unknown origin pneumonia has been furiously spreading since the late of December 2019, subsequently spread to approximately all provinces and areas in China and many countries, which was announced as a Public Health Emergency of International Concern by World Health Organization (WHO). The studies on 2019 Corona Virus Disease-19 (COVID-19) conducted from various fields around the world. Herein, the objective of the present study is to summarize the etiology, epidemiology, clinical manifestations, image findings, traceability analysis, and drug development of COVID-19.

The following electronic databases were searched Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database, VIP Chinese Science and Technology Periodical Database, and Wanfang Data. Other relevant literature will be manually searched as a compliment. We have reviewed etiology, epidemiology, clinical manifestations, image fgs, traceability analysis, drug development in patients with COVID-19.Discovering a relationship between axial length and vitreous volume would be helpful since the axial length is easier to measure than magnetic resonance imaging (MRI) parameters. This study aimed to analyze the topography of human eyes with pathological myopia through volume rendering images by high-resolution 3D-MRI and to establish a model to estimate the vitreous volume.This was a retrospective, non-randomized, controlled study of patients evaluated at Tongren Hospital from July 7, 2007 to December 12, 2018. The controls were emmetropic volunteers. All participants underwent ophthalmic examinations. Axial length was measured with an IOL Master. High-resolution 3D MRI and volume rendering was utilized for all the eyes. selleck chemicals llc Logistic regression was used to establish a model to predict the vitreous volume.A total of 280 emmetropic eyes and 290 eyes with pathological myopia were included. Males represented 60.7% and 65.5% of the individuals. The mean axial lengths of those two groups were 23.1 ± 0.8 mm (95%CI 22.7-23.4 mm) and 28.3 ± 2.2 mm (95%CI 27.5-29.2 mm), respectively (P  less then  .001). The regression model in the pathological myopic group for calculating the vitreous volume according to the axial length was Vitreous volume = 546.27 × axial length - 6977.12. The regression model in the emmetropic group for calculating the vitreous volume according to the axial length was Vitreous volume = 458.35 × axial length - 6331.14 (R = 0.360, P = .001).Elongation of the axial length is involved in eyeball enlargement in pathological myopic eyes. Measurement of the axial length could be recommended for the estimation of the vitreous volume during vitrectomy if vitreous cavity filling is needed.Button batteries are the second most frequently-ingested foreign bodies and can lead to serious clinical complications within hours of ingestion. The purpose of this study was to analyze the outcomes of 14 children with button batteries lodged in the upper gastrointestinal tract.Totally 14 children with button batteries lodged in the upper gastrointestinal tract were included. The diagnosis was made primarily by the history of button battery ingestion, physical examination and chest-abdomen X-ray examination.The button batteries lodged in the esophagus were removed by esophagoscope, and those in the gastrointestinal tract were under observation. Among 10 children with batteries in the first esophageal stenosis, 9 were cured and 1 suffered from tracheoesophageal fistula. One case of battery in the second esophageal stenosis was dead due to intercurrent aortoesophageal fistula. Two cases of batteries in the third esophageal stenosis were cured after removal, and 1 case of the battery in the gastrointestinal tract discharged spontaneously.Ingested button batteries are mainly lodged in the esophageal stenoses and are easy to cause esophageal injury and severe complications. Early detection, prompt treatment, strengthening observation and regular follow-up after discharge may help to decrease the incidence of complications and improve the outcomes.The purpose of this study is to present a new day 4 (D4) embryo grading system for the assessment of embryos in frozen-thawed embryo transfer (FET) cycles.A new grading system (grades A-E) was modified from the 2011 ESHRE Istanbul Consensus for D4 embryos in FET cycles. In total, we retrospectively analyzed 5640 embryos with known implantation data after D4 transfer in FET cycles by using this proposed grading model.The transferred embryos exhibited a similar declining trend in implantation rates from the top grade A to the lowest grade E. The implantation rates of grade B and E embryos in the in vitro fertilization group were significantly higher than that in the intracytoplasmic sperm injection group (grade B 41.82%, 35.23%, χ = 5.85, P  less then  .05 and grade E 18.53%, 14.81, χ = 76.86, P  less then  .01, respectively). The receiver operating characteristic analysis showed that our proposed model predicted the implantation outcomes of all embryos (area under the ROC curve = 0.65; 95% CI, 0.63-0.66; P  less then  .01).This study demonstrated that the new grading system provided by us turned out to be a useful tool in assisting embryo selection via embryo morphological changes, and D4 embryo transfer provided a simple and applicable method for a daily routine in FET cycles.Bladder cancer (BC) is the second most common urogenital malignant tumor. Bone metastasis (BM) is not common in BC patients, and there are only few studies on it. However, it was found in a clinical study that BM was related to the occurrence of bone complications and the decrease in survival rate. Early diagnosis of BC with BM is important for timely intervention and prevention of pathological fracture, which is of great significance for improving the quality of life of BC patients. This study aimed to identify the risk factors of BM and establish a predictive nomogram for the early diagnosis of BM in BC.The medical records of the newly diagnosed BC patients were extracted from the database of Surveillance, Epidemiology, and End Results (SEER) during 2010 to 2016. The risk factors of BC with BM were evaluated using multivariate logistic regression analysis. Then a nomogram was established to predict the risk of BC with BM.This study included 35,506 patients identified in the SEER database as diagnosed with BC, 796 of whom had BM. Grade, T stage, N stage, liver metastasis, race, brain metastasis, lung metastasis, histologic type, primary site, and age were risk predictors of BC with BM. Using Harrell's concordance index, calibration curve, and decision curve analyses, we found that the nomogram for predicting the risk of BC metastasis performed well internally.The nomogram developed in this study is expected to become an accurate and personalized tool for predicting risks of BC with BM in patients. It may be of great significance for clinicians to formulate more reasonable and effective treatment strategies. As the first study, we established a predictive nomogram for BC with BM based on the retrospective analysis of data of BC patients from the SEER database.