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1-71μg Gd/g tissue), with higher amounts observed with gadodiamide versus gadobutrol. Retention within brain tissues was only detected following HD gadodiamide administration but not LD gadodiamide nor HD or LD gadobutrol.
There was rapid systemic absorption, redistribution, and widespread multi-organ retention of Gd following IA injection of both linear and macrocyclic GBCAs, despite substantial amounts of urinary excretion. Higher concentrations of Gd were observed with administration of gadodiamide compared to gadobutrol in most tissues and biofluids.
There was rapid systemic absorption, redistribution, and widespread multi-organ retention of Gd following IA injection of both linear and macrocyclic GBCAs, despite substantial amounts of urinary excretion. Higher concentrations of Gd were observed with administration of gadodiamide compared to gadobutrol in most tissues and biofluids.
To evaluate adults with history of Osgood Schlatter disease (OSD) for imaging features of lateral patellofemoral maltracking.
In a span of four years, 10,181 unique non-contrast knee MRIs were performed on patients aged 20-50. Patients with acute trauma, prior surgery, and synovial pathologies were excluded. 171 exams had imaging findings of OSD, and an age-matched control group of 342 patients without OSD was randomly selected. Two radiologists retrospectively reviewed MRIs for features of lateral patellofemoral maltracking. Maltracking was defined as edema in superolateral Hoffa's fat or a tibial tuberosity-trochlear groove (TT-TG) distance ≥20mm with either patellar tilt/translation. Binomial logistic regression identified predictors of maltracking in OSD. Protein Tyrosine Kinase inhibitor Optimal TT-TG distance to indicate maltracking was determined by receiver operating characteristic curve.
59% (101/171) of the knees with OSD showed findings of maltracking, with patella alta, trochlear dysplasia, and quadriceps tendinosis as signiisk. Radiologists should maintain a high index of suspicion for maltracking in adults with OSD to guide clinical intervention.
There is no validated radiographic measurement to diagnose prosthetic complication(s) following total ankle replacements (TARs) although a number of angular and linear measurements, used to define the TAR position on postoperative radiographs, have been recommended to detect prosthetic loosening. The aim of this study was to test the intra- and interobserver reliability of these measurements.
This is a prospective study embedded within a multicentre cohort study. Following sample size calculation, 62 patients were analysed. Six measurements were performed on the first postoperative anteroposterior and lateral ankle radiographs angles α and β, and length "a" defined the craniocaudal position of the tibial component, while angle γ, and lengths "b" and "c" defined the angular position of the talar component. Measurements were recorded by three independent observers. Inter- and intraobserver reliability was assessed with intraclass correlation coefficient (ICC), Bland-Altman plots, and within-subject coefficients of variation (CV).
The intrarater ICC was "almost perfect" (ICC 0.83-0.97) for all six measurements. The interrater ICC was "substantial" to "almost perfect" (ICC 0.69-0.93). The mean difference in intrarater angular measurements was ≤ 0.6° and ≤ 0.8mm for linear measurements, and ≤ 2.2° and ≤ 2.1mm for interrater measurements. Maximum CV for the interrater linear measurements (≤ 17.7%) more than doubled that of the angular measurements (≤ 8.0%). The maximum width of the 95% limits of agreement was 6.5° and 8.4mm for intrarater measures, and 8.9° and 10.6mm for interrater measurements.
Angular measures are more reliable than linear measures and have potential in routine clinical practice for TAR position assessment.
Angular measures are more reliable than linear measures and have potential in routine clinical practice for TAR position assessment.
The present study aims to investigate the association of the femoral trochlear morphology with the risk of ACL injury and whether this can be considered an additional risk factor in this clinical table.
This is a retrospective case-control study with 93 patients, 41 patients with ACL total rupture (ACL-TR), and 52 patients without ACL injury who underwent knee magnetic resonance imaging (MRI) between January 2013 and January 2016. The femoral trochlear morphology was evaluated at the proximal and distal levels from the axial knee MRI. The morphological features of the trochlea using sulcus angle, sulcus depth, condylar heights, trochlear sulcus height, percentage of condyles and trochlear sulcus height to transepicondylar width, and lateral and medial trochlear inclination were evaluated. The notch width index was measured on the coronal MR images for notch stenos.
ACL-TR group had a significantly higher sulcus angle (p= 0.00-0.001) and lower sulcus depth (p = 0.00-0.002) than the control group at both ysplasia on ACL.In the situation of a shortage of ventilation beds, ethically justifiable, transparent and comprehensible decisions must be made. This concept proposes that all patients are first intubated depending on necessity and then assessed by a triage team afterwards. In this situation newly admitted COVID patients compete with newly admitted Non-COVID patients as well as patients already treated in intensive care units for a ventilator. The combination of short-term and long-term prognoses should enable the interprofessional triage team to make comprehensible decisions. The aim of the prioritization concept is to save as many human lives as possible and to relieve the treatment team of the difficult decision on prioritization.
Illustration of surgical treatment of all types of femoral neck fractures other than type AO 31-E/2.1 (Delbet type IB) through the lateral approach INDICATIONS Femoral neck fractures a)transcervical (type AO 31-E/1.1) or Delbet type IA, respectively; b)medial femoral neck fracture (type AO 31-M/3.1I) or Delbet typeII, respectively; c)lateral femoral neck fracture (type AO 31-M/3.1II) or Delbet typeIII, respectively; d)intertrochanteric (type AO 31-M/3.1III) or Delbet typeIV, respectively.
Transepiphyseal fracture with dislocation (type AO 31-E/2.1) or Delbet type IB, respectively SURGICAL TECHNIQUE Open reduction of femoral neck fractures using lateral approach.
Early functional treatment with full range of motion of the hip joint immediately postoperatively. link2 Amount of weight bearing depending on the geometry of the fracture.
In aretrospective study, 33children (19boys and 14girls) with afemoral neck fracture were followed-up for at least one year (average follow-up was 1.6years). Average age of the ie fractures were treated conservatively with pelvic leg plaster and 30 were openly reduced and stabilized. The fractures were classified according to Delbet. There were 2 type I fractures (transepiphyseal), 12 type II fractures, 10 type III fractures and 9 type IV fractures. A very good result was achieved in 29 children (88%). The most common complication was avascular necrosis (AVN), which was observed in 3 patients, all of whom showed an unsatisfactory result. Another complication was a screw breakout that resulted in a screw change. This child also showed an unsatisfactory result. Lateral access is a standard access in traumatology as well as pediatric orthopedics which can be used safely and with few complications even in children.The participatory research approach results in changes in roles and relationships for researchers and coresearchers compared to traditional research concepts. In the form of a workshop report, this article describes reflections and findings on the question of how roles are perceived and filled in participatory health research (PHR). Researchers and practitioners from two subprojects in the research consortium PartKommPlus evaluated their experiences from several years of cooperation and developed insights into which dynamics were important for the design of roles and what should be considered for a productive development of roles.Five important elements were identified the significance of the scope for action resulting from the ties of the participants to their respective institutions; the change of roles and relationships over the course of the project time; the significance of trust for functioning cooperative relationships; the problem of information confidentiality for scientific exploitation; and the political character of the cooperation, which is based on the claim for change of participatory research and which presupposes shared basic attitudes and goals. Finally, the importance of joint reflection on role design, which contributes to the success or failure of participatory research cooperation and the quality of its results, is highlighted.
To investigate whether abnormal BMI is associated with adverse health-related quality of life (HRQoL) outcome, including severe fatigue, after 52 weeks of standard therapy (ST) plus belimumab or placebo in patients with SLE.
We analysed data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials (N = 1684). Adverse HRQoL was defined as SF-36 scores ≤ the 5th percentile in age- and sex-matched US population-based subjects, and FACIT-F scores <30. We compared BMI groups using the Pearson's χ2 test, and assessed independence with multivariable logistic regression analysis.
Overweight (BMI ≥25 kg/m2) and obese (BMI ≥30 kg/m2) patients showed increased likelihood to exhibit adverse SF-36 physical component summary (OR 1.8; 95% CI 1.4-2.3; p< 0.001 and OR 2.4; 95% CI 1.8-3.2; p< 0.001, respectively) and FACIT-F (OR 1.3; 95% CI 1.1-1.6; p= 0.010 and OR 1.5; 95% CI 1.2-2.0; p= 0.002, respectively) scores at week 52. Underweight was associated with adverse SF-36 mental component summary scores, also after adjustment for sex, ancestry, age, disease duration, disease activity, organ damage and prednisone dose during the study period (OR 2.1; 95% CI 1.2-3.6; p= 0.007). Addition of belimumab to ST independently protected against adverse SF-36 general health (OR 0.8; 95% CI 0.6-1.0; p= 0.025) and FACIT-F < 30 (OR 0.8; 95% CI 0.6-1.0; p= 0.018).
Overweight and obesity contributed to adverse physical and mental HRQoL outcomes after therapeutic intervention in SLE patients, and underweight contributed to adverse mental HRQoL outcome. link3 A protective effect of belimumab against adverse general health and severe fatigue was implicated.
Overweight and obesity contributed to adverse physical and mental HRQoL outcomes after therapeutic intervention in SLE patients, and underweight contributed to adverse mental HRQoL outcome. A protective effect of belimumab against adverse general health and severe fatigue was implicated.
Metalloproteinase (MMP)-3 and MMP-12 are proteolytic enzymes especially implicated in joint inflammation. This study aims to evaluate their association with arthritis features and hand MRI abnormalities in patients with systemic lupus erythematosus (SLE).
Fifty SLE patients, with a mean (SD) age of 48.1 (14.6) years were tested for MMP-3 and MMP-12 serum levels, then further classified according to the presence of X-Ray erosions and joint deformities. Eighteen rheumatoid arthritis patients aged 47.9 (11.8) and 14 healthy people aged 46.0 (11.0) were enrolled as control groups. A subgroup of 28 SLE patients underwent a dominant-hand MRI; the detected changes were classified and semiquantitatively scored as capsular swelling, synovitis, edematous or proliferative tenosynovitis, bone oedema, bone erosions. Statistical analysis was performed using multiple regression models.
MMP-3 were significantly higher in patients with Jaccoud's arthropathy (JA) (22.1 ng/ml, p< 0.05) and independently associated with hsCRP serum levels (B-coeff 0.
