Mcqueenforbes3842

The circadian rhythm is an internal timing system, which is generated by circadian clock genes. Because the circadian rhythm regulates numerous cellular, behavioral, and physiological processes, organisms have evolved with intrinsic biological rhythms to adapt the daily environmental changes. A variety of pathological events occur at specific times, while disturbed rhythms can lead to metabolic syndrome, vascular dysfunction, inflammatory disorders, and cancer. Therefore, the circadian clock is considered closely related to various diseases. Recently, accumulated data have shown that the penis is regulated by the circadian clock, while erectile function is impaired by an altered sleep-wake cycle. The circadian rhythm appears to be a novel therapeutic target for preventing and managing erectile dysfunction (ED), although research is still progressing. In this review, we briefly summarize the superficial interactions between the circadian clock and erectile function, while focusing on how disturbed rhythms contribute to risk factors of ED. These risk factors include NO/cGMP pathway, atherosclerosis, diabetes mellitus, lipid abnormalities, testosterone deficiency, as well as dysfunction of endothelial and smooth muscle cells. On the basis of recent findings, we discuss the potential role of the circadian clock for future therapeutic strategies on ED, although further relevant research needs to be performed.

To assess outcomes following early weight bearing after distal femur fracture fixation with locked lateral plating.

Retrospective cohort study.

Two Level 1 Academic Trauma Centers.

Patients 18years and older with distal femur fractures treated with locked lateral plating.

Early full weight bearing (defined as less than 30days from date of surgery) versus restricted post-operative weight bearing.

Composite complication comprising malunion, nonunion, surgical site infection, re-admission, or death.

270 distal femur fractures were reviewed, with 165 meeting inclusion criteria. 21 patients had been allowed early full weight bearing. Fractures were divided into two groups based on when full weight bearing was allowed post-operatively. The two groups had similar fractures as determined by the distribution of AO distal femur fracture and Su periprosthetic femur fracture classifications. The early weight bearing group was significantly older and more comorbid. Despite being older, more comorbid, and allowed early full weight bearing on their fracture fixation construct, there was no difference in the rate of composite complications between groups.

Our data contributes to the small, but growing body of literature that has found no increased rate of fracture related complications in surgically treated distal femur fractures allowed early post-operative weight bearing.

Therapeutic Level III Study.

Therapeutic Level III Study.We conducted and analyzed several internet surveys in order to understand the profile of global research integrity and ethical awareness, encompassing global population distribution. These were (1) the global distribution of Committee of Publishing Ethics (COPE) membership; (2) the global distribution of "Integrity" or "Ethics" journals; (3) the level of academic integrity awareness in European higher education institutions and (4) awareness of academic integrity in the top universities of Asia and Africa. The results of this survey series highlight seriously imbalanced awareness of research integrity and publishing ethics across the world, especially in developing areas with the highest population density. We therefore propose a new index, the "Academic Integrity Awareness Index" for future discussions across the linked spheres of publishing and research.Authorship in a scientific publication is an indicator of significant intellectual contribution in scientific work. Regardless of the discipline, it is important for research-related personnel to receive credit and take responsibility for their publications. There are currently several systems of listing authorship that arise from many factors such as research complexity, pressure to obtain funding, hierarchical structure, and promotion. Some of these may unfortunately lead to authorship abuse. Raising awareness and understanding of authorship guidelines can help prevent abuses and disputes. National Science and Technology Development Agency (NSTDA) is a national research agency of Thailand with about 2 000 research staff members. The research emphasis of the agency is mainly technology development for application in broad areas, ranging from engineering to medicine, including forensic science. We conducted a survey to identify the level of awareness of NSTDA research staff and their authorship practices. A questionnaire was designed based on the International Committee of Medical Journal Editors (ICMJE) authorship guidelines and used to survey 15% of randomly selected NSTDA research staff. Nearly 90% of them responded to the interview. Among the respondents, 60% were not sure about authorship criteria. When presented with the ICMJE criteria, more than 90% agreed with the criteria except for the third one, approval of the final manuscript before submission, 33% of respondents thought that authors are only responsible for their particular contribution. However, nearly 80% agreed that every author is responsible for the integrity of the whole manuscript. These results offered an important foundation for forming a strategy to raise awareness about authorship in NSTDA. Following survey analysis, we organized several seminars and developed learning materials and an authorship guideline to increase the level of awareness of authorship for researchers.The emergence of the Internet has transformed all areas of society. This includes the universe of scientific publications, with several publishers now exclusively focusing on the electronic format and open access model while expanding to a megajournal scope. In this context, the pandemic of predatory open access journals (POAJs) and meetings are of grave concern to the academic and research community. This new shift within academia produces a variety of new victims; namely, the authors themselves. In turn, scientific knowledge is often discredited, with the public placing less trust in science. Now more than ever, performing research with integrity and selecting a journal in which to publish requires close attention and expertise. The "predatory movement" has developed increasingly sophisticated techniques for misleading people into believing what seem to be credible professional layouts and legitimate invitations. Initiatives such as the Jeffrey Beall's list, the Cabell's Scholarly Analytics and Think.Check.Submit offer some guidance to uncover the "parasitic" intervention of predatory journals and meetings, but specific education in this field is sorely needed. This work aims to review the main characteristics of predatory journals and meetings and to analyze this topic in the context of forensic and legal medicine research.We present three cases of urethral prolapse in prepubertal females in Senegal who presented with vulvar bleeding. Careful gynecologic and urologic physical exams were performed and revealed urethral origin and prolapse. Conservative versus surgical approaches were taken in different patients, but ultimately, each patient received a urethral meatoplasty. Surgical excision of these masses yielded a full recovery in the patients. A careful review of the literature was then undertaken and showed that surgical excision or ligation of the prolapse is preferable to more conservative treatment. The case series article discusses the rare occurrence of urethral prolapse, as well as the epidemiology and prognostic and therapeutic implications of urethral prolapse in prepubertal females. Introduction. Urethral prolapse is a rare condition occurring mostly in young black females. It can be worrying to the parents as it often causes vulvar bleeding. Case Presentation. We present three cases of urethral prolapse in prepubertal females who presented with vulvar bleeding. 1-Naphthyl PP1 in vivo Physical exams were performed and revealed urethral origin and prolapse. Each patient underwent a urethral meatoplasty and subsequently experienced a full recovery after respective follow-up of 2 years, 1 year, and 1 year. Conclusion. Urethral prolapse is a rare condition which can be managed successfully by surgery. Plain Language Summary. This case report on pediatric urethral prolapse showcases the different presentations and modalities of treatment, as the literature does not show that a specific treatment is always undertaken. In some countries, there are strong social considerations and they demonstrate difficulty separating sexual abuse from genitourinary pathologies, which are important to address in the treatment of these conditions.The use of cruciate substituting (CS) total knee replacement has been increasing in popularity. There are numerous factors that have likely contributed to this expansion. The CS philosophy incorporates the ease of use commonly cited by advocates of the posterior stabilized (PS) total knee design with the bone preservation associated with a cruciate retaining (CR) design. The ultra-congruent highly cross-linked polyethylene liner increases stability without an appreciable change in wear. Furthermore, balancing the flexion and extension gaps does not require "titrating" the posterior cruciate ligament, improving the user-friendliness. This paper reviews the nuances of this implant design compared to PS and CR designs as well as provides surgical technique recommendations/considerations.

Acute coronary syndrome (ACS) causes pathophysiological changes in exercise capacity, N-terminal part of pro-brain natriuretic peptide (NT-proBNP), and adiponectin that impact the course of coronary artery disease and clinical outcomes after cardiac rehabilitation (CR). However, the serial changes and the relationship between the changes in these parameters for a prolonged term remain uninvestigated.

Eighty-one patients with ACS underwent a three- or four-week CR program after acute care and were followed up for 12 months. Exercise capacity on a cycle ergometer and blood levels of NT-proBNP and adiponectin were determined before and after CR as well as at the 12-month follow-up.

Exercise capacity increased from 100 watts (in median) before CR to 138 watts after CR and 150 watts at 12 months. The NT-proBNP level (526 pg/ml before CR) remained almost unchanged after CR (557 pg/ml) and then decreased at 12 months (173 pg/ml). The adiponectin level (14.5 

g/ml before CR) increased after CR (16.0 

g/ml) and at 12 months (17.2 

g/ml). There was no significant correlation among the changes in these parameters at each observation time point.

During the observation period from before CR to the 12-month follow-up, exercise capacity, NT-proBNP, and adiponectin underwent significant changes; however, these changes were independent from each other and not correlated linearly, and they provide complementary information in clinical practice. Thus, all these parameters should be included and determined at different time points for a prolonged period of time.

During the observation period from before CR to the 12-month follow-up, exercise capacity, NT-proBNP, and adiponectin underwent significant changes; however, these changes were independent from each other and not correlated linearly, and they provide complementary information in clinical practice. Thus, all these parameters should be included and determined at different time points for a prolonged period of time.