Arildsenhess9835
Whereas, in the QSPR modelling of phenyl-based compounds, the numerical values of r T r a i n i n g 2 , r V a l i d a t i o n 2 , Q T r a i n i n g 2 and Q V a l i d a t i o n 2 were in the range of 0.867-0.896, 0.852-0.865, 0.816-0.850 and 0.760-0.762, respectively. The structural attributes, which are promoters of l o g K e a q - increase/decrease are also extracted from the SMILES notation for mechanistic interpretation. These QSPR models can also be applied to compute the reaction rate constants of organic contaminants.
This study aimed to identify demographic and psychological predictors of seasonal influenza vaccination intentions and behaviour among a sample of inpatients in a secure forensic mental health service. It also sought to explore patient experiences about being offered the vaccine.
This study used a mixed-methods design. The quantitative element employed a prospective design using a questionnaire; both cross-sectional and prospective findings are reported. For the qualitative part of the study, semi-structured interviews were conducted and analysed using Interpretative Phenomenological Analysis (IPA).
Seasonal influenza vaccination intentions and behaviour.
Past behaviour, vaccine knowledge and cues to action were predictors of vaccination intention (N = 57). Cues to action remained as the only statistical predictor of vaccination behaviour (N = 55). Nine interviews were conducted with four vaccinated and five unvaccinated participants. Three main themes were formed in the IPA analysis; these were 'Managing Decisional Conflict', 'Interaction with Immune Function' and 'The Role of Others'.
The results highlighted the integral role of health professionals in shaping patient's vaccination behaviour within a secure mental health setting. Recommendations for vaccination promotion strategies were offered.
The results highlighted the integral role of health professionals in shaping patient's vaccination behaviour within a secure mental health setting. Recommendations for vaccination promotion strategies were offered.Empirical research on the origins of kinky erotic desires (e.g., sadomasochism, bondage, domination/submission, roleplaying, sexual fetishism, etc.) has been limited and rarely rooted in the narratives of kinky people themselves. Among a sample of 260 self-identified kinky users of a kink-oriented social networking website living in 21 countries, we examined self-reported narratives of the origins of kink desires. selleck An inductive coding process by four independent coders yielded 20 categories of responses, organized into five broad discourses about the origins of kinky desires identity (e.g., personality, personal taste, and role exploration; 72.7% of responses), nurture (e.g., both traumatic and non-traumatic life experiences; 38.1% of responses), negation (e.g., disavowing or doubting a particular idea about the origins of their kink interests; 24.6% of responses), nature (e.g., biology and genetics; 22.7% of responses), and uncertainty (e.g., not being able to identify an origin of kinky desires; 10.4% of responses). Fewer than 19% of participants mentioned any kind of trauma in their responses. We discuss implications for scientific understandings of kinky sexual desire within the umbrella of sexual diversity.The objective of this study was to leverage and compare multiple machine learning techniques for predicting the human body model response in restraint design simulations. Parametric simulations with 16 independent variables were performed. Ordinary least-squares (OLS), least absolute shrinkage and selection operator (LASSO), neural network (NN), support vector regression (SVR), regression forest (RF), and an ensemble method were used to develop response surface models of the simulations. The hyperparameters of the machine learning techniques were optimized through grid search and cross-validation to avoid under-fitting and over-fitting. The ensemble method outperformed other techniques, followed by LASSO, SVR, NN, RF, and OLS. Findings indicated that optimizing the metamodel hyper-parameters are essential to predict the optimum set of restraint design parameters.
To examine the reliability to model cellular S-values for the Auger electron (AE) emitters,
In,
Hg and
Hg with MCNP6 and their relative dose deposition in subcellular targets.
A model cell was defined as four concentric spheres consisting of the nucleus (N), cytoplasm (Cy), cell and nuclear membranes (CM, NM) in which radionuclides distributed homogeneously. The transport of AE, conversion electrons and photons were simulated by MCNP6 to calculate cellular S values (S
, S
, S
, S
, S
, S
). S
, S
and S
were also calculated with MIRDcell.
MIRDcell and MCNP6-calculated S
were in excellent agreement, but a slight discrepancy on S
and S
was observed. The ratios of S
or S
vs. S
were 9.7-51.0 or 10.5-37.4, 7.9-41.8 or 8.4-31.8 and 7.2-36.9 or 8.0-28.1 for
In,
Hg,
Hg, respectively. The mean S(
Hg)/S(
In) and S(
Hg)/S(
In) were 2.5 ± 0.5 and 2.5 ± 0.6, respectively.
Cellular S-values were reliably calculated with MCNP6.
Hg and
Hg deposit two-fold more doses than
In at the subcellular scale. All AE emitters deposit a higher self-dose in the CM and NM than in the N, which warrants studies on the effects of targeting the CM and NM by AE emitters.
Cellular S-values were reliably calculated with MCNP6. 197Hg and 197mHg deposit two-fold more doses than 111In at the subcellular scale. All AE emitters deposit a higher self-dose in the CM and NM than in the N, which warrants studies on the effects of targeting the CM and NM by AE emitters.Background Hydroxychloroquine (HCQ) is one of the repurposed drugs proposed for the treatment of coronavirus disease 2019 (COVID-19). However, all the published clinical trials involve oral administration of the drug, although the disease is primarily a respiratory one. Direct inhaled delivery could reduce the side effects associated with oral use and ensure a high concentration of the drug in the lungs. In this study, inhalable HCQ powders were prepared and characterized for potential COVID-19 therapy. Methods Hydroxychloroquine sulfate (HCQ-sul) was jet milled (JM) followed by conditioning by storage at different relative humidities (43%, 53%, 58%, and 75% RHs) for 7 days. The solid-state properties, including particle morphology and size distribution, crystallinity, and vapor moisture profiles of HCQ-sul samples, were characterized by scanning electron microscopy, laser diffraction, X-ray powder diffraction, differential scanning calorimetry, thermogravimetric analysis, and dynamic water vapor sorption. Th used for clinical testing as a potential inhaled COVID-19 treatment.Ideal correlation is one variable model based on so-called optimal descriptors calculated with simplified molecular input-line entry systems (SMILES). The optimal descriptor is calculated according to the index of ideality of correlation, a new criterion of predictive potential of quantitative structure-property/activity relationships (QSPRs/QSARs). The aim of the present study was the building and estimation of models for inhalation toxicity as No Observed Adverse Effect Concentration (NOAEC) based on the OECD guidelines 413. Three random distributions into the training set and validation set were examined. In practice, a structured training set that contains active training set, passive training set and calibration set is used as the training set. The statistical characteristics of the best model for negative logarithm of NOAEC (pNOAEC) are for training set n = 108, average r2 = 0.52 + 0.62 + 0.76/3 = 0.63 and for validation set n = 35, r2 = 0.73.
To investigate the regulatory effect of long non-coding RNA (lncRNA) SUMO1P3 on invasion, migration and cell cycle of gastric cancer (GC) cells through Wnt/β-catenin signaling pathway.
Tumor tissues and adjacent normal tissues from the GC patients were collected, and human normal gastric epithelial cells GES1 and GC cells SGC-7901, MKN45, HGC-27 and AGS were selected for study. The expression of SUMO1P3 in GC tissues and cells were detected by RT-qPCR. The effects of SUMO1P3 on the proliferation, invasion and migration of SGC-7901 and MKN45 cells were detected by CCK-8, transwell and wound healing assay respectively, and the effects of SUMO1P3 on apoptosis and cycle progression of SGC-7901 and MKN45 cells were detected by flow cytometry. The expressions of Wnt/β-catenin pathway-related and cell cycle-related proteins were detected by Western blot.
The expression of SUMO1P3 was significantly upregulated in GC tissues and cell lines. Downregulation of SUMO1P3 significantly inhibited the SGC-7901 and MKN45 cell proliferation, invasion, migration, and cycle progression and promoted the cell apoptosis, while overexpression of SUMO1P3 showed the opposite effect. Further study showed that downregulation of SUMO1P3 significantly reduced the expressions of Wnt1, β-catenin, c-myc, and Cyclin D1 in SGC-7901 and MKN45 cells.
SUMO1P3 may promote invasion, migration, and cycle progression of SGC-7901 and MKN45 cells by enhancing the Wnt/β-catenin pathway.
SUMO1P3 may promote invasion, migration, and cycle progression of SGC-7901 and MKN45 cells by enhancing the Wnt/β-catenin pathway.
To examine the relationship between patterns of alcohol use, as determined by the Alcohol Use Disorders Identification Test, and vehicle control measures in high fidelity driving simulation among adult sober drivers.
Baseline data (BAC = 0.00%; N = 108) from a larger study aimed at using high-fidelity driving simulation (National Advanced Driving Simulator) to evaluate the feasibility of vehicle-based sensors to identify alcohol impairment were analyzed. Driving simulation scenarios included driving on urban, interstate, and rural roadways. The independent variable was the pattern of alcohol use measured with the Alcohol Use Disorder Identification Test (AUDIT). Dependent variables included one lateral vehicle control measure (i.e., standard deviation of lane position (SDLP)) and one longitudinal vehicle control measure (i.e., average speed relative to the speed limit) in high fidelity driving simulation. Multivariable linear regression was used to examine the associations between patterns of alcohol use ically oriented alcohol-misuse prevention efforts.
The findings support our hypothesis that the AUDIT score and responses to individual AUDIT questions, among sober drivers, relates to vehicle control measures. Overall, our data highlight two important themes 1) a need to further integrate alcohol use metrics with high-fidelity driving simulation studies to understand how drinking experience can relate to driver behavior and vehicle control and 2) the opportunity to integrate clinical perspectives with driving simulation research to strengthen clinically oriented alcohol-misuse prevention efforts.The assumptions people make from body shape can have serious implications for the well-being of the individuals inhabiting such bodies. Fat people are subject to pervasive and resilient social stigma and discrimination, leading to negative mental and physical health outcomes, including negative sexuality-related outcomes. Though previous studies have examined the personality traits attributed to, or the sexual attractiveness of, varying body shapes, no research has asked participants to make attributions of sexual traits to varying body shapes. The purpose of this study was thus to examine sexuality-related trait inferences made from body shapes. Participants (N = 891, 70% women, Mage = 25.28) were randomly assigned to view 5 computer-generated 3-dimensional body models of varying shapes developed using the skinned multi-person linear model. Participants rated their sexual attraction to each body and the degree to which each of 30 traits (10 personality and 20 sexual) applied. Results demonstrated that larger bodies are generally viewed as less sexually attractive.
