Dentontherkelsen8033

60 patients of the Narcological Clinic "Neogene" were enrolled into the study. The following participation criteria were used a diagnosis of mental and behavioral disorders associated with ephedrone use; withdrawal state. Brequinar concentration Toxic encephalopathy; age - 20-65 years; gender - male. Patients were selected and diagnosed for the study according to ICD-10 criteria. The study was conducted in compliance with bioethical principles, based on informed consent. The main study group (Group I) consisted of 45 patients and the control group (Group II) - of 15 patients. The study strictly observed anonymity and confidentiality of the participants. Thiogamma drug (alpha-lipoic acid, meglumine salt, manufacturer WÖRWAG PHARMA) with a daily dose of 600 mg was added for a duration of one month, to the standard treatment regimen of the patients of the Group I in both inpatient and outpatient settings. The patients (both inpatient and outpatient) in the Group II were treated with placebo drug along with standard treatment for the same period. Clinico-neurological disorders of the patients were evaluated before and after a one-month therapy course. Neurological examination and Unified Parkinson Disease Rating Scale - UPDSR - were used. Based on the study materials it can be reported that the users of homemade ephedron group psychostimulants ("Jeff") had neurological disorders, mainly manifested with the symptoms of Parkinson's disease; with well-expressed dystonia, postural instability, pseudobulbar and vegetative syndromes. As a result of the treatment, a decrease in the scores on the UPDSR was observed (improved condition) in patients of both groups, however, the improvement was greater expressed in the patients of Group I where Thiogamma (alpha-lipoic acid meglumine salt) drug was added to the standard treatment protocol. The above results clearly speak to the effectiveness of "Thiogamma" in the treatment of neurological disorders caused by the use of homemade psychostimulants ("Jeff").The article describes the peculiarities of suicidal behavior depending on sociodemographic characteristics, such as sex, age, level of education, housing conditions, social and family status. The article also considers the ethnic peculiarities of persons and the influence of ethnoculture on the development of suicidal behavior in the studied persons. Patients participated in the study. The purpose of this work is to assess the structure of suicidal emotional disorders in their relationship with socio-economic factors. The research material was clinical data on 131 patients of the psychoneurological dispensary in Shymkent city, including 79 men and 52 women from different age groups (from 18 to 72 years) during five years. Mathematical methods resulted in the identification of common features of suicidal behavior as well as factors influencing suicidal behavior.The aim of the study was to study the relationship between non-verbal intelligence, education and the factor of social functioning, taking into account the gender of patients with schizophrenia in childhood and adolescence. It should be noted that no such study was conducted in Georgia. The article discusses one of the most serious mental illnesses - schizophrenia, in terms of social functioning, since social functioning is an indicator of the degree of degradation of the patient. 246 patients with schizophrenia aged 18 to 45 years were examined. Studies have shown that the premorbid intelligence of the patient increases the degree of social adaptation. The higher the non-verbal intelligence, which is an integral part of the intellectual development of patients, the higher the indicators of social activity and adaptation, especially for women. The coefficient of social functioning does not obey the law of normal distribution. Any level of patient education is not a positive factor, although it does not significantly affect the functioning of female patients. The higher the level of non-verbal intelligence, the better the indicators of social activity, especially among women, although in general this dependence is insignificant. The article notes that in accordance with a complex, biopsychosocial approach, along with drug treatment, rehabilitation and social support of patients are necessary. The role of the human environment and other life circumstances of the patient in the severity of schizophrenia is discussed. A number of recommendations are presented that contribute to stopping cognitive decline and, therefore, preserving adaptive skills.The goal of our research was to study the to identify key aspects of the management of emotional disorders in the practice of operative treatment of proximal femoral fractures in elderly patients. The study was conducted with 24 patients who needed surgical treatment of proximal femoral fracture and were at risk for the development of psycho-emotional disorders due to the presence of emotional disorders of an anxiety-depressive nature were examined. The presence of such disorders was recorded at the time of admission, before and after surgical treatment using specialized psychodiagnostic techniques. Mini Mental State Examination, modified Hachinski ischemic scale, Frontal assessment battery, Spielberg-Khanin Scale of Reactive and Trait Anxiety, The Zung Self-Rating Depression Scale were used. Results of the clinical study of the Most patients at risk had a high level of reactive anxiety - 14 (58.33%) patients (equally in subgroups I and II - 7 (29.17%) patients in each) compared with moderate levels (10 (41.6nd sub-depressive state (depressive disorders) reactive anxiety (42.52±0.05), trait anxiety (42.23±0.07) and depressive disorders (51.41±0.07). It is proved that the treatment of emotional disturbances of the anxiety-depressive spectrum lead to a significant levelling in existing psychological changes.The deterioration of the existing emotional disorders of the anxiety-depressive spectrum among patients at risk in the absence of drug treatment has been established.The goal is to develop and evaluate the effectiveness of a psychoeducational program (PP) aimed at timely detection, prevention of the formation and prevention of chronicity of mental disorders in internally displaced persons (IDPs). 414 IDPs took part in the research. A complex of clinical-psychopathological, psychometric, psychodiagnostic and statistical methods were used. It was found that the group of IDPs is heterogeneous and includes 3 categories of persons group I - IDPs without signs of mental disorders (conditionally healthy) (53,86%), group II - IDPs with individual symptoms of mental disorders (risk group) (20,05%) and group III - IDPs with established mental disorders (26,09%). The examined IDPs of the III group were found mental disorders, predominantly of the anxiety-depressive spectrum. Factors of psychic traumatization (FPT) were assessed in a dynamic aspect retrospectively (during of staying in the anti-terrorist operation (ATO) zone), 12 and 24 months after leaving the ATO zone and during of examination. The dynamics of FPT and their significance in time and with regard to gender specificity were shown. In order to timely identify and prevent the formation of mental disorders in IDPs and increase their adaptive capabilities, it is proposed to use PP, which had a group structured work format. The results of its approbation were presented and it were proved that the using of PP could significantly increase the level of psychological adaptation of IDPs by reducing the level of mental stress, reactive anxiety and the severity of negative perception of the future and improving the quality of life.Common variable immunodeficiency (CVID) is a kind of hypoimmunoglobulinemia of different spectrum with a dominant decrease of IgG with heterogeneity of clinical manifestations. In this publication, we provide an analysis of some world research sources on the diagnosis and treatment of the CVID and description of a clinical case of the CVID and the structural analysis of its frequency among primary immunodeficiencies in the adult population. We described the clinical case that demonstrates unusual manifestation of adult's outcome of CVID with cellular immune deficiencies and immunoglobulin А deficiency and RAG-2 gene mutation. There is the prevalence of CVID and hereditary hypo-/agammaglobulinemias among the primary diagnosed immunodeficiencies in the inhabitants of the Kyiv region, that is given the severity of clinical manifestations and need of replacement immunoglobulinotherapy. As early prognostic marker for the development of CVID and other defects of antibodies an immunoglobulin E deficiency can be considered.The study of the clinical and laboratory dynamics after an intensive phase of treatment in patients with firstly diagnosed pulmonary tuberculosis (FDTB) with alcohol consumption, and the development of a method for predicting the effectiveness of treatment. Examined 109 men with FDTB aged 20 to 50 years. Depending on the level of alcohol consumption, 3 groups of patients were formed. Patients of each group divided into two subgroups depending on the treatment regimen. The highest response to antioxidant therapy had indicators of phagocytic and enzymatic activity of neutrophils and endogenous intoxication. The dynamics of a decrease in all indicators of oxidative stress in groups 1 and 2 was higher in patients who additionally received antioxidants. The positive effects of group 3 was less. The models of prediction the positive dynamics level in the treatment of patients depending on the scheme therapy received have been developed. Predictors of treatment efficacy for patients with FDTB and alcohol intake with standard therapy are baseline alcohol consumption level, phagocytic index, and blood lymphocyte count. When prescribing antioxidants to a standard therapy regimen - initial level of alcohol consumption and phagocytic number. The degree of alcohol consumption is a common determinant of treatment effectiveness, regardless of treatment regimen.HCV infection and its complications, especially hepatocellular carcinoma, is a substantial public health burden. In 2015 "Nationwide hepatitis C elimination program" was launched in Georgia. According to the protocol, patients with HCC also receive DAA antiviral treatment. We study the effect of the different DAA therapy regiments on the incidence or recurrence of HCC and its prognosis. Overall, 408 patients were recruited in Georgian-French Joint Hepatology Clinic HEPA between April 2015-March 2016. The selection criteria were as follows 1 - age 50-65 years; 2. Liver fibrosis level F3-F4 or cirrhosis at least 15 years of disease history; 3. HCV positive diagnosed by PCR method, whatever the level of viral load and genotype; 4. absence of previous complications of cirrhosis (ascites, gastrointestinal bleeding or HCC; 5. Child-Pugh class A or B; and 6. absence of severe extrahepatic disease. Essential clinical and biological parameters were recorded. Clinical monitoring and management of adverse events were performed on a regular base. HCV All patients included in the study received anti-HCV treatment with direct-acting antivirals (DAAs) within the national hepatitis C elimination program in accordance with national protocols. During April 2015-March 2016 treatment was provided with sofosbuvir (SOF) in combination with ribavirin (RBV), with or without pegylated interferon (IFN). Since March 2016, ledipasvir/sofosbuvir (LDV/SOF) was prescribed to all patients with or without RBV depending on the HCV genotype, level of fibrosis, and previous treatment experience. In conclusion, we find that neither different DAA regimens nor different treatment duration affects HCC risk after antiviral treatment. Moreover, there are no significant changes in mortality rate due to HCC in these groups. Therefore, it can be concluded, that HCC status is not a contraindication for DAA treatment, especially at the early stages of cancer, when a tumor is curative.