Jantzencarstensen5374

The proposed method was trained and evaluated on ISIC-2016 and ISIC-2017 skin lesion datasets. It achieved an average Jaccard Index of 85.96% and 80.05% for ISIC-2016 and ISIC-2017 datasets, when trained individually. When trained on combined dataset (ISIC-2016 and ISIC-2017), the proposed method achieved an average Jaccard Index of 80.73% and 90.02% on ISIC-2017 and ISIC-2016 testing datasets. The proposed methodological framework can be used to design a fully automated computer-aided skin lesion diagnostic system due to its high scalability and robustness.In the field of intelligent manufacturing, robot grasping and sorting is important content. However, there are some disadvantages in the traditional single-view-based manipulator grasping methods by using a 2D camera, where the efficiency and the accuracy of grasping are both low when facing the scene of stacking and occlusion for the reason that there is information missing by single-view 2D camera-based methods while acquiring scene information, and the methods of grasping only can't change the difficult-to-grasp scene which is stack and occluded. Regarding the issue above, a pushing-grasping collaborative method based on the deep Q-network in dual viewpoints is proposed in this paper. This method in this paper adopts an improved deep Q-network algorithm, with an RGB-D camera to obtain the information of objects' RGB images and point clouds from two viewpoints, which solved the problem of lack of information missing. What's more, it combines the pushing and grasping actions with the deep Q-network, which make it have the ability of active exploration, so that the trained manipulator can make the scenes less stacking and occlusion, and with the help of that, it can perform well in more complicated grasping scenes. In addition, we improved the reward function of the deep Q-network and propose the piecewise reward function to speed up the convergence of the deep Q-network. We trained different models and tried different methods in the V-REP simulation environment, and it drew a conclusion that the method proposed in this paper converges quickly and the success rate of grasping objects in unstructured scenes raises up to 83.5%. Besides, it shows the generalization ability and well performance when novel objects appear in the scenes that the manipulator has never grasped before.This study aimed to investigate whether serum indicators related to iron stores in the body are associated with clinical and endoscopic disease severity. Eighty-four patients with Crohn's disease (CD) and twenty-four healthy volunteers were included. The indicators related to iron stores were detected within one week after endoscopic and CT enterography examinations. Infigratinib in vitro Patients were divided into three groups according to the CDAI(Crohn's disease activity index)scores. Serum iron levels were decreased in all groups (p  0.05). Underweight, decreased serum iron and TIBC were independent risk factors for moderate clinical disease. Combined detection of decreased serum iron and TIBC was helpful in differentiating severe patients. The sensitivity and specificity were 32.7% and 100%, respectively (AUC = 0.812, p  less then  0.01). Decreases in serum iron and TIBC were associated with the clinical activity of CD. Combined detection of the two indicators was conducive to screening serious disease.In recent years, the problem of addressing fairness in machine learning (ML) and automatic decision making has attracted a lot of attention in the scientific communities dealing with artificial intelligence. A plethora of different definitions of fairness in ML have been proposed, that consider different notions of what is a "fair decision" in situations impacting individuals in the population. The precise differences, implications and "orthogonality" between these notions have not yet been fully analyzed in the literature. In this work, we try to make some order out of this zoo of definitions.Sea urchins and sea cucumbers are mutually beneficial organisms in kelp ecosystem. As herbivores, sea urchins process kelp through feeding and egestion, providing inaccessible food for benthic consumers such as sea cucumbers. Sea urchins in turn profit from the sediment cleaned by sea cucumbers. However, behavioral interactions between them remain poorly understood, which greatly hampers our understanding on the relationship between ecologically important benthic species in marine ecosystems and the regulating mechanism. The present study investigated behavioral interactions between sea urchins Strongylocentrotus intermedius and sea cucumbers Apostichopus japonicus in laboratory conditions. We revealed that the presence of sea urchins caused significant higher speed movement of A. japonicus. Interestingly, the negative effects of S. intermedius on A. japonicus were significantly reduced in the shared macroalgal area. For the first time, we found the interspecific responses to alarm cues between sea cucumbers and sea urchins. Conspecific responses were significantly larger than the interspecific responses in both sea urchins and sea cucumbers. This indicates that interspecific response to alarm cues is an efficient approach to anti-predation and coexistence in mutually beneficial organisms. The present study shed light on the interspecific relationships and coexistence between sea urchins and sea cucumbers in kelp ecosystem.This prospective study assessed the dual-curing self-adhesive bulk-fill restorative Surefil one. The restorations were placed and reviewed by dental practitioners who are members of a practice-based research network in the United States. Seven practitioners filled 60 cavities (20 class I, 19 class II and 21 class V) in 41 patients with Surefil one without adhesive, according to the manufacturer's instructions. The restorations were evaluated using modified USPHS criteria at baseline, 3 months, and 1 year. Patients were also contacted to report postoperative hypersensitivity one to four weeks after placement. The only patient that showed moderate hypersensitivity after 1 year had previously reported symptoms that were unlikely associated to the class I molar restoration. One class II restoration in a fractured maxillary molar was partially lost. The remaining restorations were found to be in clinically acceptable condition resulting in an annual failure rate of 2%. Color match showed the lowest number of acceptable scores (88%) revealing significant changes over time (P = 0.0002). No significant differences were found for the other criteria (P > 0.05). The novel self-adhesive bulk-fill restorative showed clinically acceptable results in stress-bearing class I and II as well as non-retentive class V cavities at 1-year recall.Sepsis is a major reason for preventable hospital deaths. A cluster-randomized controlled trial on an educational intervention did not show improvements of sepsis management or outcome. We now aimed to test an improved implementation strategy in a second intervention phase in which new intervention hospitals (former controls) received a multifaceted educational intervention, while controls (former intervention hospitals) only received feedback of quality indicators. Changes in outcomes from the first to the second intervention phase were compared between groups using hierarchical generalized linear models controlling for possible confounders. During the two phases, 19 control hospitals included 4050 patients with sepsis and 21 intervention hospitals included 2526 patients. 28-day mortality did not show significant changes between study phases in both groups. The proportion of patients receiving antimicrobial therapy within one hour increased in intervention hospitals, but not in control hospitals. Taking at least two sets of blood cultures increased significantly in both groups. During phase 2, intervention hospitals showed higher proportion of adequate initial antimicrobial therapy and de-escalation within 5 days. A survey among involved clinicians indicated lacking resources for quality improvement. Therefore, quality improvement programs should include all elements of sepsis guidelines and provide hospitals with sufficient resources for quality improvement.Trial registration ClinicalTrials.gov, NCT01187134. Registered 23 August 2010, https//www.clinicaltrials.gov/ct2/show/study/NCT01187134 .Vascular injury models are indispensable for studying thrombotic processes in vivo. Amongst the available methods for inducing thrombosis, laser-induced endothelial injury (LIEI) has several unique advantages. However, a lack of methodological standardization and expensive instrumentation remain significant problems decreasing reproducibility and impeding the adoption of LIEI in the wider scientific community. In this, study, we developed a standardized protocol for scanning laser-induced endothelial injury (scanning-LIEI) of murine mesenteric veins using the intrinsic 405 nm laser of a conventional laser scanning confocal microscope. We show that our model produces thrombi with prominent core-shell architectures and minimal radiation-related fluorescence artefacts. In comparison with previous methods, the scanning-LIEI model exhibits reduced experimental variability, enabling the demonstration of dose-response effects for anti-thrombotic drugs using small animal cohorts. Scanning-LIEI using the intrinsic 405 nm laser of a confocal laser scanning microscope represents a new method to induce standardized vascular injury with improved reproducibility of thrombus formation. The reduced need for instrument customisation and user experience means that this model could be more readily adopted in the research community.The identification of technological and policy interventions allowing to improve the performance of Beninese rice systems is necessary to reduce the heavy dependence on rice imports. This study characterized the Beninese rice farming systems, identified the production constraints, and determinants of the adoption of improved varieties by farmers. Four hundred eighteen rice farm households were surveyed across 39 villages using participatory research tools and methods. Cluster analysis was used to classify the surveyed farm households and revealed four typologies of rice farming systems differentiated by 8 variables. These are, the intensive rice farming system (cluster 4; 33.7%), semi-intensive rice farming system (cluster 1; 31.8%), integrated rice-livestock farming system (cluster 3; 11.8%), and subsistence rice farming (cluster 2; 22.7%). The integrated rice-livestock farming system was the dominant type practiced in the northern Benin, while, it is the intensive rice farming system in the south. Fifteen production constraints across rice-growing areas were recorded. Our results suggest that to increase adoption of improved rice varieties, agricultural extension services should target landowners' farmers practicing off-season rice production, and having other sources of income. Initiatives to boost rice production in Benin should prioritize the establishment of formal agricultural credit and mechanization option policies.Sloth bears behave aggressively toward humans when threatened and are among the most dangerous wildlife in India. Safety messaging for those who live in sloth bear country must be accurate to be effective, and messaging may need to be modified to account for regional differences in human-bear relationships. The timing of sloth bear attacks on the Deccan Plateau of Karnataka, both by season and by time of day, deviated enough from those reported in other areas such that it warranted further investigation. We compared data from eight studies of human-sloth bear conflict from across the Indian subcontinent and explored possibilities as to why differences exist. Seasonally all studies reported that human-sloth bear conflict was highest when human activity in the forest was greatest, though the season of highest human activity varied significantly by region (χ2 = 5921, df = 5, P  less then  0.001). The time of day that the majority of attacks occurred also varied significantly by region (χ2 = 666, df = 5, P  less then  0.