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Respondents most commonly adhered to MVPA (61.1%) and sleep (59.7%) guidelines. Adherence to sedentary and screen time guidelines was lower (56.3% and 36.2%, respectively). Sociodemographic factors associated with higher odds of meeting the guidelines included being female, older age, self-identifying as White, and living at high socioeconomic status. Students who reported higher psychological well-being were more likely to meet the guidelines.

Overall adherence to the new guidelines is low among post-secondary students in Canada. The CCWS provides a mechanism for monitoring the dissemination and implementation of the new Canadian 24-hour movement guidelines for adults.

Overall adherence to the new guidelines is low among post-secondary students in Canada. The CCWS provides a mechanism for monitoring the dissemination and implementation of the new Canadian 24-hour movement guidelines for adults.

Spectral-domain optical coherence tomography (SD-OCT) offers depth-resolved imaging of optical scattering contrast but is limited in sensitivity to optical absorption. Dual-modality imaging combined with the noncontact absorption contrast of photoacoustic remote sensing (PARS) microscopy can augment SD-OCT applications with specific molecular and functional contrasts in an all-optical, fiber-based platform.

To develop a fiber-based multimodal PARS and SD-OCT imaging system, which efficiently uses a common 1050-nm light source for SD-OCT and PARS interrogation.

PARS microscopy has predominantly utilized a 1310-nm interrogation light source to date. Hence, a recent dual-modality PARS and 1050-nm SD-OCT imaging system required three distinct wavelengths including a 532-nm PARS excitation, necessitating a free-space optical architecture with discrete subsystems. Here, we validate the first use of a 1050-nm interrogation wavelength for PARS. This enables the transition to fiber-based interferometry as is stanabled implementation of a fiber-based dual-modality system configuration, with image quality maintained. H2DCFDA solubility dmso This will facilitate development of potential applications demanding handheld, catheter-based, or endoscopic form factors.

Oral cancer is among the most common cancers globally, especially in low- and middle-income countries. Early detection is the most effective way to reduce the mortality rate. Deep learning-based cancer image classification models usually need to be hosted on a computing server. However, internet connection is unreliable for screening in low-resource settings.

To develop a mobile-based dual-mode image classification method and customized Android application for point-of-care oral cancer detection.

The dataset used in our study was captured among 5025 patients with our customized dual-modality mobile oral screening devices. We trained an efficient network MobileNet with focal loss and converted the model into TensorFlow Lite format. The finalized lite format model is ∼16.3  MB and ideal for smartphone platform operation. We have developed an Android smartphone application in an easy-to-use format that implements the mobile-based dual-modality image classification approach to distinguish oral potentially malignant and malignant images from normal/benign images.

We investigated the accuracy and running speed on a cost-effective smartphone computing platform. It takes ∼300  ms to process one image pair with the Moto G5 Android smartphone. We tested the proposed method on a standalone dataset and achieved 81% accuracy for distinguishing normal/benign lesions from clinically suspicious lesions, using a gold standard of clinical impression based on the review of images by oral specialists.

Our study demonstrates the effectiveness of a mobile-based approach for oral cancer screening in low-resource settings.

Our study demonstrates the effectiveness of a mobile-based approach for oral cancer screening in low-resource settings.The health of ecosystems and human health are closely linked. Interdisciplinary approaches and initiatives such as "One-Health," "EcoHealth," and, more recently, "Planetary Health" articulate this link. The three concepts are based on recognizing the interdependence between living organisms, both human and non-human, and their ecosystems. And yet, we are living in a time when human activity is leading to a profound degradation of the environment all over the world. Nine planetary boundaries for earth system processes have been proposed who's critical thresholds should not be crossed if we want to maintain our ecosystems and avoid risk of unwelcome outcomes 1) climate change, 2) loss of biodiversity, 3) disturbances in biogeochemical cycles of nitrogen and phosphorus, 4) deforestation and changes in land use, 5) chemical pollution, 6) ocean acidification, 7) depletion of the ozone layer, 8) the degradation of drinking water, and 9) aerosol pollution. These "planetary bounderies" are suggested to represent a framework within which human activity can develop safely while still allowing the Earth systems to function sustainably. Yet several of these thresholds have already been crossed or are in a risky zone of uncertainty. This is all the more worrying because the connect ions between these various forms of environmental degradation and to human health are nonlinear and complex.The health of ecosystems and human health are closely linked. Interdisciplinary approaches and initiatives such as "One-Health," "EcoHealth," and, more recently, "Planetary Health" articulate this link. The three concepts are based on recognizing the interdependence between living organisms, both human and non-human, and their ecosystems. And yet, we are living in a time when human activity is leading to a profound degradation of the environment all over the world. Nine planetary boundaries for earth system processes have been proposed who's critical thresholds should not be crossed if we want to maintain our ecosystems and avoid risk of unwelcome outcomes 1) climate change, 2) loss of biodiversity, 3) disturbances in biogeochemical cycles of nitrogen and phosphorus, 4) deforestation and changes in land use, 5) chemical pollution, 6) ocean acidification, 7) depletion of the ozone layer, 8) the degradation of drinking water, and 9) aerosol pollution. These "planetary bounderies" are suggested to represent a framework within which human activity can develop safely while still allowing the Earth systems to function sustainably. Yet several of these thresholds have already been crossed or are in a risky zone of uncertainty. This is all the more worrying because the connect ions between these various forms of environmental degradation and to human health are nonlinear and complex.

The aim of this study was to explore the role of primary care facilities and their support measures in response to coronavirus disease 2019 (COVID-19) and to identify challenges to achieving public-private cooperation in South Korea.

Twenty-four leading experts were selected and recruited to participate in this iterative web-based Delphi study. An open-ended questionnaire was administered to collect the expert panel's views in the first round. In the second round, the panel was asked to rate on a 5-point Likert scale their agreement with individual items gleaned from qualitative content analysis of views expressed in the first round. The participants were offered the opportunity to reevaluate and correct their initial responses in subsequent rounds. Responses in the second and following rounds were analyzed using quantitative descriptive statistics.

The first and second rounds were completed by 54.2% (n=13/24) and 58.3% (n=14/24) of the selected panel, respectively, while 10 out of these 14 participants completed the third round. The panel cited in-person essential medical services, telehealth for fever/respiratory symptoms, surveillance for influenzae-like illness, and minimization of spread to staff as important and appropriate roles of primary care, which are urgent and feasible during a pandemic. Regarding conditions/support for these roles, the panel indicated that institutional support and funding for separate areas, workforce, and telehealth, along with public-private collaborative governance, are urgent, but not feasible.

This study provides guidance on strategies for continuing the required roles of primary care and highlights a need to strengthen public-private partnerships during pandemic events in Korea.

This study provides guidance on strategies for continuing the required roles of primary care and highlights a need to strengthen public-private partnerships during pandemic events in Korea.

Our previous work demonstrated that miRNA-495 targets SOX9 to inhibit chondrogenesis of mesenchymal stem cells. In this study, we aimed to investigate whether miRNA-495-mediated SOX9 regulation could be a novel therapeutic target for osteoarthritis (OA) using an in vitro cell culture model.

An in vitro model mimicking the OA environment was established using TC28a2 normal human chondrocyte cells. Interleukin-1β (IL-1β, 10 ng/mL) was utilized to induce inflammation-related changes in TC28a2 cells. Safranin O staining and glycosaminoglycan assay were used to detect changes in proteoglycans among TC28a2 cells. Expression levels of COX-2, ADAMTS5, MMP13, SOX9, CCL4, and COL2A1 were examined by qRT-PCR and/or Western blotting. Immunohistochemistry was performed to detect SOX9 and CCL4 proteins in human cartilage tissues obtained from patients with OA.

miRNA-495 was upregulated in IL-1β-treated TC28a2 cells and chondrocytes from damaged cartilage tissues of patients with OA. Anti-miR-495 abolished the effect of IL-1β in TC28a2 cells and rescued the protein levels of SOX9 and COL2A1, which were reduced by IL-1β. SOX9 was downregulated in the damaged cartilage tissues of patients with OA, and knockdown of SOX9 abolished the effect of anti-miR-495 on IL-1β-treated TC28a2 cells.

We demonstrated that inhibition of miRNA-495 alleviates IL-1β-induced inflammatory responses in chondrocytes by rescuing SOX9 expression. Accordingly, miRNA-495 could be a potential novel target for OA therapy, and the application of anti-miR-495 to chondrocytes could be a therapeutic strategy for treating OA.

We demonstrated that inhibition of miRNA-495 alleviates IL-1β-induced inflammatory responses in chondrocytes by rescuing SOX9 expression. Accordingly, miRNA-495 could be a potential novel target for OA therapy, and the application of anti-miR-495 to chondrocytes could be a therapeutic strategy for treating OA.

Long non-coding RNA (lncRNA) is identified as an important regulator involved in oral squamous cell carcinoma (OSCC) tumorigenesis. This study aimed to investigate the functional role and underlying mechanism of LINC00662 in OSCC.

The expression levels of LINC00662, miR-144-3p, and enhancer of zeste homolog 2 (EZH2) mRNA were quantified with quantitative real-time polymerase chain reaction in OSCC tissues and cell lines. Western blot analysis was used to assay the expression levels of E-cadherin, Vimentin, and EZH2. Cell proliferation, migration, and invasion were monitored by cell counting kit-8 and Transwell assays. Dual-luciferase reporter and RNA immunoprecipitation assays were employed to verify the regulatory relationship between LINC00662 and miR-144-3p.

The expression of LINC00662, positively associated with the increased TNM stage and lymph node metastasis of the patients, was up-regulated in OSCC tissues and cells. The overexpression of LINC00662 facilitated the proliferation, migration, and invasion of OSCC cells.