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LF-EMF could prevent the disappearance of myotubes, with different magnetic flux densities of LF-EMF exerting independent and positive effects on skeletal myogenesis such as satellite cell activation and proliferation, muscle cell differentiation, and myocyte fusion.

LF-EMF could prevent the disappearance of myotubes, with different magnetic flux densities of LF-EMF exerting independent and positive effects on skeletal myogenesis such as satellite cell activation and proliferation, muscle cell differentiation, and myocyte fusion.

Hydroxyapatite bioceramic is a kind of bone implant commonly used in oral clinic treatment. In the early stage of tissue repair, cells will suffer hypoxic due to the interruption of blood supply.

Studying the expression of osteoblasts in hypoxic environment will help us to understand the expression and response mechanism of osteoblasts at the implantation site of hydroxyapatite in the early stage of hypoxia.

MG63 osteoblast cell line was used in this study. The cells of normal group were incubated under normal oxygen and hydroxyapatite ceramics condition. The cells of hypoxia group were incubated under hypoxia (37∘C, 8% CO2, 8% O2, 86% N2) and hydroxyapatite ceramics condition. Cell proliferation was measured by CCK8 assay. Apoptosis was measured by flow cytometry. Serum alkaline phosphatase (ALP) activity was measured by ALP kit. Hypoxia inducible factor (HIF-α) and vascular endothelial growth factor (VEGF) were detected by Western blot.

Compared to the normal group, the cells of hypoxia group showed a dramatically higher proliferation ability, especially at 48h (P< 0.05). Due to hypoxia, cell apoptosis was induced, but there is no difference between these two groups. Interestingly, the ALP activity of hypoxia group was higher than that of normal group at 24h and 48h (P< 0.05). Mechanically, western blot result showed that the protein level of both HIF-α and VEGF were up-regulated in hypoxia group.

Under hypoxia condition, hydroxyapatite bioceramics can promote the proliferation of MG63 osteoblasts, elevate the activity of alkaline phosphatase and upregulate HIF-α and VEGF expression without effect on apoptosis.

Under hypoxia condition, hydroxyapatite bioceramics can promote the proliferation of MG63 osteoblasts, elevate the activity of alkaline phosphatase and upregulate HIF-α and VEGF expression without effect on apoptosis.

The occurrence and development of caries is a complex process affected by multiple factor.

The present study was envisaged to evaluate the plaque fluid in caries free children and children with high caries, in order to establish a data set of bacterial secretion proteomics. A non-labeled quantitative technique based on two-dimensional liquid chromatography-series mass spectroscopy was employed to detect plaque fluid. Based on the proteomics data, the database search, data processing and pathway analysis illuminated the function of these proteins, and clarified the role of plaque microecology in caries occurrence and development.

The study enrolled 8 caries free (CF) children, whose decayed-missed-filled surface of teeth is 0 (dmfs = 0), and caries sensitive (CS) children, whose decayed-missed-filled surface of teeth is > 10(dmfs > 10) (3 ∼ 5years old) for the smooth tooth plaque and the plaque in the high caries group. The plaque protein was extracted using the unlabeled quantitative technique likally rich in 101 pathways, including glycolysis pyruvate acid metabolism, tricarboxylic acid cycle, pentyl phosphate pathway, fructose mannose metabolism, starch and sucrose metabolism, and ABC transporters.

Our study obtained the largest known dataset of the bacterial secretion protein in children with high caries, and screened the data set of high caries state. 603 peptides were statistically rich in 101 pathways, including glycolysis pyruvate acid metabolism, tricarboxylic acid cycle, pentyl phosphate pathway, fructose mannose metabolism, starch and sucrose metabolism, and ABC transporters.

The routine radiation therapy treatment planning does not include secondary radiation and peripheral doses resulting from radiotherapy exposure in patients with nasopharyngeal carcinoma (NPC) undergoing Volumetric Modulated Arc Therapy (VMAT) using an linear accelerator (linac) of Axesse (Elekta 2538).

VMAT has a better dose conformity of the tumor and is also operated by adjusting the shapes of mulileaf collimator. However, such treatment is potentially important to improve the accuracy of estimated health risks.

This study aimed to evaluate the equivalent dose of organ or tissue (DT) and effective dose (E) for normal organs using the Alderson Rando phantom as an equivalent of the human body. Thermoluminescent dosimeters (TLD-100H) were calibrated by 6 MV X-ray originated by the linac. A total of 252 TLDs were used. PF2545920 These TLDs were inserted into phantom organ or tissue which closely approximated to these places.

The thyroid dose (D

High installation and operating cost have limited applications for many circumstances. In practice, primary and shielding coils cannot insert into the magnet pole simultaneously owing to deficient workspace for the planar permanent MRI systemsOBJECTIVE To minimize eddy currents induced in the resist-eddy current plates and pole piece when the gradient coil current switches on and off rapidly.

A theoretical framework that have minimum power dispassion and magnetic energy with eddy plate is proposed for a planar gradient coil. The mirror image of the magnetostatic model is substituted into the stream function for designing a minimum power dispassion planar gradient coil. A finite-difference is used to formulate the coil distribution that makes magnetic field similar to the required magnetic field for gradient coil design.

A coil designed with actively shielded was simulated and compared with the designed gradient coils using mirror image theory and piece pole effect. According to the numerical evaluation of the x and z coils, the operating currents in the cases were reduced to 34.4% using magnetostatic mirror-image method to replay the active shielding. Moreover, there was a significant improvement on the shielding effect when added to resistive eddy current plate.

Using the magnetostatic mirror image theory and mirror-image model, the current density function that could not only gives the minimum power dissipation and magnetic energy with the presence of the eddy plate and pole piece effect, but also provides excellent coil performance compared with active shielding solution.

Using the magnetostatic mirror image theory and mirror-image model, the current density function that could not only gives the minimum power dissipation and magnetic energy with the presence of the eddy plate and pole piece effect, but also provides excellent coil performance compared with active shielding solution.

With the continuous expansion of urban scale and the increasing concentration of population, public health crisis has become an important part of urban residents' health management. The outbreak of the COVID-19 pandemic in Wuhan in 2020 has sounded the alarm.

With the government at all levels to carry out the construction of urban Internet of things and information internet, the Internet backbone network has been built, deployed a large number of sensors, and collected a large number of urban situation data.

In this paper, situational awareness technology is introduced into public health emergency services.

By constructing ontology, situational data and residents' health data are integrated. Through key technologies such as situational data collection, data fusion and data mining, real-time perception of environmental conditions of public health emergency scene is realized, and situational data fusion and situational information reasoning model are constructed.

The model is applied to the public health crisis emergency simulation system to verify the effectiveness of the model.

The model is applied to the public health crisis emergency simulation system to verify the effectiveness of the model.

Alternative splicing is a mechanism to produce different proteins with diverse functions from one gene. Many splicing factors play an important role in cancer progression. PRPF8 is a core protein component of the spliceosome complex, U4/U6-U5 tri-snRNP.

However, PRPF8 involved in mRNA alternative splicing are rarely included in the prognosis.

We found that PRPF8 was expressed in all examined cancer types. Further analyses found that PRPF8 expression was significantly different between the breast cancer and paracancerous tissues.

Survival analyses showed that PRPF8-high patients had a poor prognosis, and the expression of PRPF8 is associated with distant metastasis-free survival (DMFS) and post progression survival (PPS). Gene Set Enrichment Analysis (GSEA) has revealed that PRPF8 expression is correlated with TGF-β, JAK-STAT, and cell cycle control pathways. Consistent with these results, upon PRPF8 silencing, the growth of MCF-7 cells was reduced, the ability of cell clone formation was weakened, and p⁢21 expression was increased.

These results have revealed that PRPF8 is a significant factor for splicing in breast cancer progression.

These results have revealed that PRPF8 is a significant factor for splicing in breast cancer progression.

Gestational diabetes mellitus (GDM) is a metabolic disease that seriously endangers the health of mothers and children. It is important to monitor GDM in real-time before diagnosis and to prevent it effectively.

GDM was divided into the second trimester diagnosed diabetes mellitus (GDM_24) and the third trimester diagnosed diabetes mellitus (GDM_30). The risk prediction of two types of GDM was performed in normal pregnant women at 11-13 and 16-19 weeks of pregnancy, respectively.

By stages, the K-W test was used to analyze the differences between basic information and energy metabolism factors, and multiple logistic regression was used to analyze the risk of energy metabolism factors and to correct the confounders with significant differences.

For the GDM_24 group, each additional unit of oxygen consumption (VO2), carbon dioxide production, and resting energy expenditure (REE) increased the risk by 2.4%, 3.5%, 0.4%, and 2.1%, 2.6%, and 0.3%, respectively, at 11-13 and 16-19 weeks of pregnancy. For the GDM_30 group, each additional unit of VO2 and REE was associated with an increased risk of 2.3% and 0.3%, respectively, at 16-19 weeks of pregnancy.

The risk of GDM_30 only appeared in pregnant women during 16-19 weeks of pregnancy, which may indicate that GDM_24 and GDM_30 have different pathogenesis.

The risk of GDM_30 only appeared in pregnant women during 16-19 weeks of pregnancy, which may indicate that GDM_24 and GDM_30 have different pathogenesis.

Tongue inspection is vital in traditional Chinese medicine. Fissured tongue is an important feature in tongue diagnosis, and primarily corresponds to three Chinese medicine syndromes syndrome-related hotness, blood deficiency, and insufficiency of the spleen. Diagnosis of the syndrome is significantly affected by the experience of clinicians, and it is difficult for young doctors to perform accurate diagnoses.

The syndrome not only depends on the local features based on fissured regions but also on the global features of the whole tongue; therefore, a syndrome diagnosis framework combining the global and local features of a fissured tongue image was developed in the present study to achieve a quantitative and objective diagnosis.

First, we detected the fissured region of a tongue image using a single-shot multibox detector. Second, we extracted the global and local features from a whole tongue image and a fissured region using TongueNet (developed in-house). Third, we developed a classifier to determine the final syndrome.