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Since the inception of the National Programme for Family Planning, messages on family planning (FP) have been promoted across India using different mass media platforms. Mass media plays an important role in disseminating important information among the masses, such as how reversible modern methods give women more reproductive choices than opting for permanent methods that limit their child-bearing capacity. Mass media can provide a continuous flow of information and motivation to deter women from discontinuing the methods they have opted for. However, very few studies have been conducted on this issue, especially using recently available data. This study particularly focuses on exposure to mass media and the use of reversible modern methods of family planning among married women in India. The data for this study was obtained from the National Family Health Survey (2015-16) on currently married women aged 15-49 years. The association of reversible modern method use with media exposure variables was examined, voluntary contraceptive use in India. An increase in mass media exposure coupled with improvement in coverage and services of the FP program can significantly increase the use of reversible modern methods in a cost-effective yet efficient manner among women in need of FP services.As a powerful tool in hyperspectral image (HSI) classification, sparse representation has gained much attention in recent years owing to its detailed representation of features. In particular, the results of the joint use of spatial and spectral information has been widely applied to HSI classification. However, dealing with the spatial relationship between pixels is a nontrivial task. This paper proposes a new spatial-spectral combined classification method that considers the boundaries of adjacent features in the HSI. Based on the proposed method, a smoothing-constraint Laplacian vector is constructed, which consists of the interest pixel and its four nearest neighbors through their weighting factor. Then, a novel large-block sparse dictionary is developed for simultaneous orthogonal matching pursuit. Our proposed method can obtain a better accuracy of HSI classification on three real HSI datasets than the existing spectral-spatial HSI classifiers. Finally, the experimental results are presented to verify the effectiveness and superiority of the proposed method.

Mycoplasma pneumoniae is one of the main causes of community-acquired pneumonia. Due to the imperfect immune system of children, this also causes Mycoplasma pneumoniae pneumonia (MPP) to be more common in children. Globally, the incidence of MPP in children is gradually increasing. This study was the first to systematically review the clinical efficacy and safety of Shuanghuanglian (SHL) oral preparations combined with azithromycin in the treatment of MPP in children.

This study fully retrieved 3 Chinese databases and 5 English databases to search the randomized controlled trials (RCTs) of SHL oral preparations combined with azithromycin in the treatment of children with MPP. The search time is from the inception to September 2020. Data extraction and risk bias evaluation were performed independently by two researchers. We conducted a Meta-analysis of all the outcome indicators. Besides, Meta-regression, subgroup analysis, and heterogeneity analysis were used for the primary outcomes to find the possible her verification.

Based on the results of meta-analysis with low certainty evidence, we believed that SHL oral preparations combined with azithromycin likely be effectively improved clinical symptoms compared with azithromycin alone. Low certainty evidence showed that SHL may safety with no serious adverse events. Due to these limitations, the safety needs further verification. More high-quality, multicenter, and large-sample RCTs should be tested and verified in the future.

Based on the results of meta-analysis with low certainty evidence, we believed that SHL oral preparations combined with azithromycin likely be effectively improved clinical symptoms compared with azithromycin alone. Low certainty evidence showed that SHL may safety with no serious adverse events. Due to these limitations, the safety needs further verification. More high-quality, multicenter, and large-sample RCTs should be tested and verified in the future.The treatment of complex diseases often relies on combinatorial therapy, a strategy where drugs are used to target multiple genes simultaneously. Promising candidate genes for combinatorial perturbation often constitute epistatic genes, i.e., genes which contribute to a phenotype in a non-linear fashion. Experimental identification of the full landscape of genetic interactions by perturbing all gene combinations is prohibitive due to the exponential growth of testable hypotheses. Here we present a model for the inference of pairwise epistatic, including synthetic lethal, gene interactions from siRNA-based perturbation screens. The model exploits the combinatorial nature of siRNA-based screens resulting from the high numbers of sequence-dependent off-target effects, where each siRNA apart from its intended target knocks down hundreds of additional genes. We show that conditional and marginal epistasis can be estimated as interaction coefficients of regression models on perturbation data. We compare two methodss of siRNA perturbation screens on various pathogens. The identified interactions include both known epistatic interactions as well as novel findings.Reopening amid the COVID-19 pandemic has triggered a battle on social media. The supporters perceived that the lockdown policy could damage the economy and exacerbate social inequality. By contrast, the opponents believed it was necessary to contain the spread and ensure a safe environment for recovery. Anatomy into the battle is of importance to address public concerns, beliefs, and values, thereby enabling policymakers to determine the appropriate solutions to implement reopening policy. To this end, we investigated over 1.5 million related Twitter postings from April 17 to May 30, 2020. With the aid of natural language processing (NLP) techniques and machine learning classifiers, we classified each tweet into either a "supporting" or "opposing" class and then investigated the public perception from temporal and spatial perspectives. From the temporal dimension, we found that both political and scientific news that were extensively discussed on Twitter led to the perception of opposing reopening. Further, being the first mover with full reopen adversely affected the public reaction to reopening policy, while being the follower or late mover resulted in positive responses. From the spatial dimension, the correlation and regression analyses suggest that the state-level perception was very likely to be associated with political affiliation and health value.

The burden of heart failure is growing in sub-Saharan Africa, but there is a dearth of data characterizing care and outcomes of heart failure patients in the region, particularly in emergency department settings.

In a prospective observational study, adult patients presenting with shortness of breath or chest pain to an emergency department in northern Tanzania were consecutively enrolled. Participants with a physician-documented clinical diagnosis of heart failure were included in the present analysis. Standardized questionnaires regarding medical history and medication use were administered at enrollment, and treatments given in the emergency department were recorded. Thirty days after enrollment, a follow-up questionnaire was administered to assess mortality and medication use. Multivariate logistic regression was performed to identify baseline predictors of thirty-day mortality.

Of 1020 enrolled participants enrolled from August 2018 through October 2019, 267 patients (26.2%) were diagnosed with heain the emergency department setting.

In a northern Tanzanian emergency department, heart failure is a common clinical diagnosis, but uptake of evidence-based outpatient therapies is poor and thirty-day mortality is high. Interventions are needed to improve care and outcomes for heart failure patients in the emergency department setting.Spain was, together with Italy, the first European country severely affected by the COVID-19 pandemic. After one month of strict lockdown and eight weeks of partial restrictions, Spanish residents are expected to have revised some of their beliefs. We conducted a survey one year before the pandemic, at its outbreak and during de-escalation (N = 1706). Despite the lockdown, most respondents tolerated being controlled by authorities, and acknowledged the importance of group necessities over individual rights. However, de-escalation resulted in a belief change towards the intrusiveness of authorities and the preeminence of individual rights. Besides, transcendental beliefs-God answering prayers and the existence of an afterlife-declined after the outbreak, but were strengthened in the de-escalation. Results were strongly influenced by political ideology the proportion of left-sided voters who saw authorities as intrusive greatly decreased, and transcendental beliefs prevailed among right-sided voters. Our results point to a polarization of beliefs based on political ideology as a consequence of the pandemic.Fetal movement count monitoring is one of the most commonly used methods of assessing fetal well-being. While few methods are available to monitor fetal movements, they consist of several adverse qualities such as unreliability as well as the inability to be conducted in a non-clinical setting. Therefore, this research was conducted to design a complete system that will enable pregnant mothers to monitor fetal movement at home. This system consists of a non-invasive, non-transmitting sensor unit that can be fabricated at a low cost. An accelerometer was utilized as the primary sensor and a micro-controller based circuit was implemented. Clinical testing was conducted utilizing this sensor unit. Two phases of clinical testing procedures were done and during the first phase readings from 120 mothers were taken while during the second phase readings from 15 mothers were taken. selleck compound Validation was done by conducting an abdominal ultrasound scan which was utilized as the ground truth during the second phase of the clinical testing procedure. A clinical survey was also conducted in parallel with clinical testings in order to improve the sensor unit as well as to improve the final system. Four different signal processing algorithms were implemented on the data set and the performance of each was compared with each other. Out of the four algorithms three algorithms were able to obtain a true positive rate around 85%. However, the best algorithm was selected on the basis of minimizing the false positive rate. Consequently, the most feasible as well as the best performing algorithm was determined and it was utilized in the final system. This algorithm have a true positive rate of 86% and a false positive rate of 7% Furthermore, a mobile application was also developed to be used with the sensor unit by pregnant mothers. Finally, a complete end to end method to monitor fetal movement in a non-clinical setting was presented by the proposed system.