Bergmanndelgado5463

After external beam radiotherapy to her sacrum, a good response without any side effects was achieved.

Laparoscopic insertion of pelvic tissue expander prior EBRT and it's subsequent removal after EBRT is safe and effective method for displacing loops of bowel out of the pelvis. With minimal morbidity converts untreatable disease to treatable by allowing delivering high doses of radiation to the patient.

After 2 years of follow up the disease is in remission and the patient without any major complaint.

After 2 years of follow up the disease is in remission and the patient without any major complaint.High solid anaerobic digestion (HSAD) was an emerging bioconversion technology which had the advantages of small digester, less digestate and low heating energy. A one-stage anaerobic system in CSTR by inoculating activated sludge of simultaneous propionate degradation and methanogenesis was proposed to improve the high-solid digestion performance and to stabilize the reaction process. Semi-continuous mode was successfully used to perform HSAD from cellulosic ethanol whole stillage at an initial substrate loading of 15.4% (w/w) dry matter content with different OLRs from 1.5 to 5.0 gVS·L-1 d-1 at an HRT of 30 days. The average methane yield during whole digestion reached 349.9 mL⋅gVS-1 with a total VS removal rate of 61.3%. The acclimation mechanism of multifunctional activated sludge was also explored by analyzing the functional property, physiological activity and microbial community structure. The results indicated the feasibility and efficiency of multifunctional activated sludge in a semi-continuous high-solid stirred tank reactor system.The influence of copper ion (Cu2+) on anaerobic ammonium oxidation (anammox) performance and microbial community structures after oxytetracycline (OTC) stress recovery were assessed. Experimental results demonstrated that anammox performance were stressed by 1.0 mg L-1 Cu2+ and inhibitions were reversible with total nitrogen removal rate higher than 3.08 ± 0.2 kg N m-3 d-1. The residual OTC in the anammox sludge could combine with Cu2+ introduced and thereby retarded inhibition on performance in the presence of 2.0 mg L-1 Cu2+. Moreover, the positive relation of dominant bacterium Ca. Anammoxoglobus with the abundance of functional genes and parts of antibiotic resistance genes were observed, suggesting that regain of performance was the results of the gradual domestication of latent resistant species after inhibition. This investigation reveals new insights into resistance of anammox performance for Cu2+ and OTC.Zanthoxylum bungeanum meal (ZBM) is the by-product of Z. bungeanum seeds after pressing. It is restricted as a feed additive because it contains stimulating and potentially harmful substances, which are alkylamides and alkaloids. This study described the use of Lactobacillus paracasei and L. acidipiscis isolated from ZBM in solid-state fermentation of ZBM to reduce the concentration of undesirable alkylamides and alkaloids. By optimizing the substrate and fermentation conditions, the minimum contents of alkylamide and alkaloid were 2.96 and 3.20 mg/g, and the degradation rates reached 51.86% and 39.59%, respectively. Moreover, the biotransformation pathways of hydroxyl-α-sanshool and chelerythrine were established by identifying the metabolites. Bacterial diversity was shift significantly, and the relative abundance of Lactobacillus increased from 0.10% to 99.0% after fermentation. In conclusion, this study introduced a reliable strategy for processing ZBM as a feed additive.This study was aimed at developing a compound microbial agent to facilitate the composting of Chinese medicinal herbal residues (CMHRs). Different microbial agents were inoculated into a mixture of CMHRs, sheep manure, and biochar and composted for 42 days. The results demonstrated that the compound microbial agent (K1 + P1 + N4) inoculated in T1 can extend the thermophilic period during composting. Compared with control check (CK), the total nutrient contents of the vaccinated groups increased by 5.45-28.54%, and T1 had the highest value. The total organic carbon degradation rate and germination index of T1 were 1.95 and 1.03 times higher than those of the control. Moreover, significant increases in the abundance and diversity of the microbial community were also found in T1. Consequently, using K1 + P1 + N4 as a microbial agent for the composting of CMHRs is recommended, and this research provides a new idea to solve the problem of waste of CMHRs.Managing plastic waste remains an urgent environmental concern and switching to biodegradable plastics can reduce the dependence on depleting fossil fuels. This study emphasises the efficacy of macroalgae wastes, Eucheuma denticulatum residues (EDRs), as potential alternate feedstock to produce l-lactic acid (l-LA), the monomer of polylactic acid, through fermentation. An innovative environmental friendly strategy was explored in this study to develop a glucose platform from EDRs pretreatment with microwave-assisted autohydrolysis (MAA) applied to enhance enzymatic hydrolysis of EDRs. The results indicate that MAA pretreatment significantly increased the digestibility of EDRs during the enzymatic hydrolysis process. The optimum pretreatment conditions were 120 °C and 50 min, resulting in 96.5% of enzymatic digestibility after 48 h. The high l-LA yield of 98.6% was obtained using pretreated EDRs and supplemented with yeast extract. The energy analysis implies that MAA pretreatment could further improve the overall energy efficiency of the process.The organics (C) and nitrogenous (N) pollutants removal paths by functional units in vegetation-activated sludge process (V-ASP) were investigated by using stable isotope probing and high-throughput sequencing for the first time. V-ASP system displayed superior treatment performance compared to conventional activated sludge system, as manifested by its greater C and N removal efficiencies, higher abundance of denitrifying and heterotrophic functional Genus, and better resistance to low temperature. Isotope δ13C and δ15N were continuously accumulated in plant roots allocated in the V-ASP, where suspended sludge demonstrated obviously higher C and N enrichment rates compared to the rhizosphere sludge. The mass balance estimation showed that bacterial dissimilation was the dominant removal paths for C (54.13%) and N (47.53%). The underlying pollutants removal paths evidenced the advantageous of V-ASP that is a high feasible and promising approach for decentralized wastewater treatment process.Aging is inevitable when biochar uses for remediate Cadmium (Cd) pollution, but the variation of adsorption mechanism remains unclear. This study uses ramie residue to prepare fresh biochar, and adopt it with acidification and oxidation to simulate the aging process. The difference of physicochemical properties between fresh and aged biochar are studied through microstructure. Then, two kinds of biochar are making adsorption experiments in Cd solution for analyzing their adsorption mechanism. The results show that, both chemisorption and physisorption are exist, chemisorption and physisorption is the predominant way of fresh biochar and aged biochar respectively. Cation exchange is important but weaker in aged biochar than fresh biochar. Carboxyl plays a leading role in complexation of fresh biochar and hydroxy in aged biochar. Coprecipitation and cation-π mechanism impair apparently in aged biochar. This study indicates that aging change ramie biochar's main adsorption mechanism and the primary chemisorption way.The performance stability and its recovery mechanisms of a partial nitritation-anammox process were investigated. A one-stage airlift enhanced micro-granules (AEM) system was operated for 650 days continuously to treat 50 mg-NH4/L wastewater. see more During the stable stage, a high nitrogen removal efficiency of 72.7 ± 8.4% lasting for 230 days was successfully achieved under 0.28 L/min aeration rate and 0.10-0.20 mg/L dissolved oxygen (DO) concentration. A microbial consortium with good granularity appeared in red. The specific activity of anammox and ammonia oxidation increased to 1.02 and 0.93 g-N/g-VSS/d, respectively. Meanwhile, the microbial analysis showed the AEM system shifted the dominant microflora from Proteobacteria to Planctomycetes in which Candidatus Brocadia abundance reached a high of 35.0%. The results reveal that the long-term airlift-aeration promoted granulation and further enhanced activities, the abundances of anammox bacteria, and suppressed nitrite-oxidizing bacteria. Optimizing the DO control is also critical for stability increment and process recovery.Currently, anaerobic sludge digestion (ASD) is considered not only for treating residual sewage sludge and energy recovery but also for the reduction of antibiotic resistance genes (ARGs). The current review highlights the reasons why antibiotic resistant bacteria (ARB) and ARGs exist in ASD and how ASD performs in the reduction of ARB and ARGs. ARGs and ARB have been detected in ASD with some reports indicating some of the ARGs can be completely removed during the ASD process, while other studies reported the enrichment of ARB and ARGs after ASD. This paper reviews the performance of ASD based on operational parameters as well as environmental chemistry. More studies are needed to improve the performance of ASD in reducing ARGs that are difficult to handle and also differentiate between extracellular (eARGs) and intracellular ARGs (iARGs) to achieve more accurate quantification of the ARGs.With the increasing of data in wastewater treatment, data-driven machine learning models are useful for modeling biological processes and complex reactions. However, few data-driven models have been developed for simulating the microbial electrolysis cells (MECs) and traditional models are too ambiguous to comprehend the mechanisms. In this study, a new general data-driven two-stage model was firstly developed to predict CH4 production from in-situ biogas upgrading in the biocathode MECs via direct electron transfer (DET), named NARX-BP hybrid neural networks. Compared with traditional one-stage model, the model could well predict methane production via DET with excellent performance (all R2 and MES of 0.918 and 6.52 × 10-2, respectively) and reveal the mechanisms of biogas upgrading, for the new systematical modeling approach could improve the versatility and applicability by inputting significant intermediate variables. In addition, the model is generally available to support long-term prediction and optimal operation for anaerobic digestion or complex MEC systems.

P-glycoprotein (P-gp) over-expression plays a vital role in not only systemic drug bioavailability but also cancer multi-drug resistance (MDR). Develop functional inhibitors of P-gp can conquer both problems.

The aim of the present study was to research the P-gp modulating effects and MDR reversing ability of a novel flavonoid from Fissistigma cupreonitens, the underlying inhibitory mechanisms were further elucidated as well.

Calcein-AM, rhodamine 123, and doxorubicin were fluorescent substrates for the evaluation of P-gp inhibitory function and detailed drug binding modes. Docking simulation was performed to reveal the in silico molecular bonding. ATPase assay and MDR1 shift assay were adopted to reveal the ATP consumption and conformational change of P-gp. The MDR reversing effects were demonstrated through cytotoxicity, cell cycle, and apoptosis analyses.

5‑hydroxy‑7,8‑dimethoxyflavanone inhibited the efflux of rhodamine 123 and doxorubicin in a competitive manner, and increased the intracellular fluorescence of calcein at a concentration as low as 2.