Lauritzenwu1793

A mixture of coal bottom ash and slag, with a fraction of fly ash (CAFAS) from steam locomotives, was placed in the cave Divaška jama to delimit and level tourist trails. Emplacement began in 1914 and carried on for several decades. The CAFAS mixed with other cave material gradually changed its structure and appearance. Currently the concentration of some elements in the CAFAS (As, Cu, Hg, Ni, Pb, Zn), and also to a lesser extent in cave sediments (Cr, Cu, Ni), indicates a possibly harmful effect on sediment-associated biota based on ecotoxicological assays. Compared to the cave sediment, the CAFAS contains distinctly different mineral phases and presents a different source of radioactivity. Microbial metabolic activity of CAFAS is low, 0.22 μl O2/gDW h, but higher than that of cave sediment. The present environmental hazards from CAFAS are estimated to be low. Whereas the emplacement of CAFAS was seen initially a long-term solution for waste disposal and management of the cave, it turned out that CAFAS enriches the underground environment with inorganic and organic compounds and disperses pollution into the cave ecosystem. After its removal from the cave, the CAFAS should be investigated thoroughly due to its susceptibility to alteration.The associations between hypertension, diabetes, and dyslipidemia with Bell's palsy have been controversial and only a few studies have assessed risk factors for Bell's palsy based on population-based data. The aim of the present study was to evaluate whether sociodemographic factors such as sex, age, residence, household income, and metabolic diseases such as hypertension, diabetes, and dyslipidemia were risk factors for Bell's palsy using the National Health Insurance Service National Sample Cohort data of Korea. Patients who visited an outpatient clinic twice or more or had one or more admission and received steroid medication under the International Classification of Diseases diagnostic codes for Bell's palsy from 2006 to 2015 were defined as patients with Bell's palsy in this study. The associations between sociodemographic factors and metabolic diseases to Bell's palsy were analyzed with univariate and multivariate Cox proportional hazard regression models. There were 2708 patients with Bell's palsy recorded from 2006 to 2015. Male sex, advanced age, residence in a location other than the capital and metropolitan cities, hypertension, and diabetes were significant risk factors for Bell's palsy. This study is significant for patients and providers because we analyzed the relationships using a population-based database over a long-term follow-up period.Ginkgo biloba L. is an ancient relict plant with rich pharmacological activity and nutritional value, and its main physiologically active components are flavonoids and terpene lactones. The bZIP gene family is one of the largest gene families in plants and regulates many processes including pathogen defense, secondary metabolism, stress response, seed maturation, and flower development. In this study, genome-wide distribution of the bZIP transcription factors was screened from G. biloba database in silico analysis. A total of 40 bZIP genes were identified in G. biloba and were divided into 10 subclasses. GbbZIP members in the same group share a similar gene structure, number of introns and exons, and motif distribution. Analysis of tissue expression pattern based on transcriptome indicated that GbbZIP08 and GbbZIP15 were most highly expressed in mature leaf. And the expression level of GbbZIP13 was high in all eight tissues. Correlation analysis and phylogenetic tree analysis suggested that GbbZIP08 and GbbZIP15 might be involved in the flavonoid biosynthesis. The transcriptional levels of 20 GbbZIP genes after SA, MeJA, and low temperature treatment were analyzed by qRT-PCR. The expression level of GbbZIP08 was significantly upregulated under 4°C. Protein-protein interaction network analysis indicated that GbbZIP09 might participate in seed germination by interacting with GbbZIP32. Based on transcriptome and degradome data, we found that 32 out of 117 miRNAs were annotated to 17 miRNA families. The results of this study may provide a theoretical foundation for the functional validation of GbbZIP genes in the future.Mixed-signal analog/digital circuits emulate spiking neurons and synapses with extremely high energy efficiency, an approach known as "neuromorphic engineering". However, analog circuits are sensitive to process-induced variation among transistors in a chip ("device mismatch"). For neuromorphic implementation of Spiking Neural Networks (SNNs), mismatch causes parameter variation between identically-configured neurons and synapses. DSS Crosslinker chemical structure Each chip exhibits a different distribution of neural parameters, causing deployed networks to respond differently between chips. Current solutions to mitigate mismatch based on per-chip calibration or on-chip learning entail increased design complexity, area and cost, making deployment of neuromorphic devices expensive and difficult. Here we present a supervised learning approach that produces SNNs with high robustness to mismatch and other common sources of noise. Our method trains SNNs to perform temporal classification tasks by mimicking a pre-trained dynamical system, using a local learning rule from non-linear control theory. We demonstrate our method on two tasks requiring temporal memory, and measure the robustness of our approach to several forms of noise and mismatch. We show that our approach is more robust than common alternatives for training SNNs. Our method provides robust deployment of pre-trained networks on mixed-signal neuromorphic hardware, without requiring per-device training or calibration.The article attempts to define and determine the intangible components of cultural heritage related to the spatial structure of land in a comprehensive way using computational methods. The components were quantified and a method of empirical evaluation of landscape durability was proposed for agricultural areas of significant cultural and historical value with an evident mosaic structure of fields, baulks, ponds, meadows, and forests. This method allows us to identify places more resistant to political transformation and those with greater cultural potential. The paper proposed an integrated approach to the measuring of the degree of preservation of spatial arrangements in the landscape based on a set of objects that describe the spatial land structure. The article classifies areas by the degree of preservation of rural spatial arrangements of land. The spatial analysis employed facilitated a synthetic quantification of the multi-criteria process. Three groups of factors were used spatial assessment of land-cover type persistence (u), agricultural land structure persistence (w), and persistence of settlement buildings (z). The final results pinpointed areas in need of strategic intervention to sufficiently protect the rural cultural heritage, properly consider them in zoning planning, and ensure their sustainable development. The proposed tool can be used to monitor the degree of changes in the landscape layout structure when multiple time points are analysed as well.Surfactant protein A (SP-A) is well-known for its protective role in pulmonary immunity. Previous studies from our group have shown that SP-A mediates eosinophil activities, including degranulation and apoptosis. In order to identify potential binding partners on eosinophils for SP-A, eosinophil lysates were subjected to SP-A pull-down and tandem mass spectrometry (MS/MS) analysis. We identified one membrane-bound protein, myeloid-associated differentiation marker (MYADM), as a candidate SP-A binding partner. Blocking MYADM on mouse and human eosinophils ex vivo prevented SP-A from inducing apoptosis; blocking MYADM in vivo led to increased persistence of eosinophilia and airway hyper-responsiveness in an ovalbumin (OVA) allergy model and increased airways resistance and mucus production in a house dust mite (HDM) asthma model. Examination of a subset of participants in the Severe Asthma Research Program (SARP) cohort revealed a significant association between epithelial expression of MYADM in asthma patients and parameters of airway inflammation, including peripheral blood eosinophilia, exhaled nitric oxide (FeNO) and the number of exacerbations in the past 12 months. Taken together, our studies provide the first evidence of MYADM as a novel SP-A-associated protein that is necessary for SP-A to induce eosinophil apoptosis and we bring to light the potential importance of this previously unrecognized transmembrane protein in patients with asthma.In this work, we present a Quantum Hopfield Associative Memory (QHAM) and demonstrate its capabilities in simulation and hardware using IBM Quantum Experience.. The QHAM is based on a quantum neuron design which can be utilized for many different machine learning applications and can be implemented on real quantum hardware without requiring mid-circuit measurement or reset operations. We analyze the accuracy of the neuron and the full QHAM considering hardware errors via simulation with hardware noise models as well as with implementation on the 15-qubit ibmq_16_melbourne device. The quantum neuron and the QHAM are shown to be resilient to noise and require low qubit overhead and gate complexity. We benchmark the QHAM by testing its effective memory capacity and demonstrate its capabilities in the NISQ-era of quantum hardware. This demonstration of the first functional QHAM to be implemented in NISQ-era quantum hardware is a significant step in machine learning at the leading edge of quantum computing.To investigate the prevalence of meibomian gland dysfunction (MGD) in patients presenting with subjective dry eye-related symptoms at their first-time consultation in a Norwegian specialized ocular surface clinic. Additionally, to explore the accuracy of the ocular surface disease index score (OSDI) as an extensively applied tool to assess the severity of dry eye symptoms and MGD diagnosis. Patients with subjective dry eye-related complaints (n = 900) attending the clinic for the first time, from 2012 to 2016, were included in the study. At the baseline, patients completed the OSDI questionnaire. Subsequently, objective clinical tests, including fluorescein break-up time (FBUT), Schirmer-I test, ocular surface staining (OSS), and meibomian gland function assessment using gland expressibility and meibum quality were performed. The association between MGD and its severity in relation to symptom severity defined by OSDI-score was examined. MGD was found in 93.8% of the study group. MGD prevalence was not significantly different between groups based on age (p = 0.302) or sex (p = 0.079). There was a significant association between severity of MGD and dry eye-related symptoms (p = 0.014). OSS was significantly higher in patients with severe symptoms (p = 0.031). Sensitivity and specificity of positive symptom-score (OSDI ≥ 13) for disclosing MGD were 85.5% and 30.4%, respectively. MGD was highly prevalent, not associated with age and sex. OSDI ≥ 13 had high sensitivity and high positive predictive value (PPV), but low specificity and negative predictive value (NPV) for disclosing MGD. This underscores the importance of meibomian gland assessment in patients with dry eye-related symptoms.