Pearsonmassey5913

CC patients with high hsa_circ_0011385 expression possessed a shorter overall survival. Hsa_circ_0011385 knockdown reduced tumor growth in vivo and facilitated apoptosis, cell cycle arrest, impeded proliferation, metastasis, invasion, and angiogenesis of CC cells in vitro. Hsa_circ_0011385 could mediate PRDX6 expression through binding to miR-149-5p. MiR-149-5p silencing reversed hsa_circ_0011385 knockdown-mediated effects on CC cell angiogenesis and malignancy. PRDX6 overexpression overturned the inhibitory effects of miR-149-5p overexpression on angiogenesis and malignant behaviors of CC cells. In conclusion, hsa_circ_0011385 accelerated angiogenesis and malignant behaviors of CC cells by regulating the miR-149-5p/PRDX6 axis, manifesting that hsa_circ_0011385 might be a therapeutic target for CC.Joint pain is a common presentation in the Emergency department. There are countless potential causes for pain and swelling in a joint. Septic arthritis is a true joint emergency as it can lead to rapid, irreversible destruction of the joint. If not diagnosed early this infection can lead to considerable functional deficit. Our case is unique in that our patient presented to the Emergency department requesting referral to the fracture clinic for continued management of a suspected scaphoid bone fracture but was found to have Neisseria gonorrhoea causing septic arthritis of the joint. This case highlights the importance of accurate history taking, clinical examination and assessment of the patients presenting with joint pain.Research on bioconversion based on insects is intensifying as it addresses the problem of reducing and reusing food and industrial waste. To reach this goal, we need to find more means of pairing waste to insects. With this goal, brewers' spent grains (BSG) - a food waste of the brewing industry - paired with the oleaginous biomass of the thraustochytrid Schizochytrium limacinum cultivated on crude glycerol - a major waste of biodiesel production - were successfully used to grow Hermetia illucens larvae. Combining BSG and S. limacinum in the diet in an attempt to design the lipid profile of H. illucens larvae to contain a higher percentage of omega-3 fatty acids is novel. Insect larvae were grown on three different substrates i) standard diet for Diptera (SD), ii) BSG, and iii) BSG + 10% S. limacinum biomass. The larvae and substrates were analyzed for fatty acid composition and larval growth was measured until 25% of insects reached the prepupal stage. Our data showed that including omega-3-rich S. limacinum biomass in the BSG substrate promoted an increase in larval weight compared to larvae fed on SD or BSG substrates. Furthermore, it was possible, albeit in a limited way, to incorporate omega-3 fatty acids, principally docosahexaenoic acid (DHA) from BSG + S. limacinum substrate containing 20% of DHA into the larval fat (7% DHA). However, H. illucens with this level of DHA may not be suitable if the aim is to get larvae with high omega-3 lipids to feed carnivorous fish.Composting recycles nutrients and biodegrades organic pollutants, but often results in N leaching. selleck inhibitor Biochar can enhance the composting process and reduce N losses. Research, however, has focused on composting N-rich residues; also, information on the fate of biochar polycyclic aromatic hydrocarbons (PAHs) during composting is scarce. We explored the composting of biochar with N-poor organic residues as a strategy to reduce N losses and biochar PAHs. A small-scale composting experiment was performed with three treatments 100% yard residues and two mixtures of 85% yard residues and 15% gasification- or pyrolysis-derived biochar. Temperatures were recorded daily during composting and Nlosses and changes in PAHs loads were calculated. Results across all treatments showed overall low N losses, likely caused by low temperatures and N contents, circumneutral pH values, and absence of leachate, and simultaneous immobilization and mineralization of PAH contents. Treatments with biochar showed a slower release of inorganic N (NO3--N and NH4+-N), although they also had overall lower inorganic N contents. This slower release of inorganic N may relate to biochar's high surface area. We conclude that biochar provides valuable benefits for N-poor composting, and that composting should be further explored as a promising strategy to reduce the contents of PAHs in biochar.Hong Kong's construction industry, known for its massive building infrastructure, produces an enormous amount of waste every year, the vast majority of which is disposed for landfills. Therefore, some effective operational measures and waste management policies have been implemented. However, enormous waste remains a concern for stakeholders and exert pressure on the limited capacity of Hong Kong's landfills. Though previous research discusses Building Information Modelling (BIM) application for construction waste management enhancement, the BIM model has not been widely implemented for building demolition with waste management. Hence, as a response to the aforementioned shortcomings, this paper develops a conceptual framework that allows collecting, maintaining, and analyzing comprehensive information through Smart BIM that uses advanced technologies such as Internet of Things (IoT) and capable of reacting to user activities such as waste quantitative assessment, demolition process planning, optimal disposal route selection, and waste management strategy are executed. The advantages of the proposed framework are shown in a case study benefit-cost analysis based on three planned reuse and recycling-rate scenarios that explain on- and off-site recycling methods. The results show that the proposed framework will pave the way for generating sustainable waste disposal practices by providing technical and decision-making support functionalities to engineers and planners in the construction industry.Modern societies are generating considerable volume of Construction and Demolition Wastes (C&DW) annually. Most recycling facilities offers viable sorting and recycling options for the coarser particles of the different materials found in those wastes. However, usual dry mechanical sorting and human sorting are not efficient on C&DW fines particles (C&DF, less then 10 mm) representing the third of the C&DW produced and being composed of similar materials. Recent environmental issues related to the landfilling of C&DF have pointed out the need to develop innovative alternative and adapted recycling paths for the C&DF. This study presents an efficient sorting process train based on physical separation steps used in the mining and the soil treatment industries. The use and recirculation of process water allowed to segregate and concentrate the gypsum from the 2-12 mm C&DF into a specific fraction (55-65% gypsum content) representing 40% of the total mass. Other constituents were sorted based on their relative density, size and shapes; thanks to hydraulic classification and physical sorting forming four more fractions with high recycling potential coarse aggregates (15%), fine aggregates (9.4%), organic and inorganic fibers (10.8%) and light organic compounds (24.8%). The process has been designed to be integrated in existing sorting facilities and the process costs were evaluated to 38 CAN$/t.Vermicomposting is characterized by transforming organic waste into nutrient-rich organic fertilizer through the action of different earthworms and microorganisms. Although vermicomposting can recycle the excess sludge in an eco-friendly manner, the longer stabilization period has limited its industrial application. The present study sought to investigate a novel operation process of vermicomposting combined with room drying (VD) to improve the stabilization efficiency of dewatered sludge. Subsequently, the performance and efficiency of vermicomposting without room drying, room dry without vermicomposting, and VD for sludge stabilization were compared simultaneously. In the VD process, the sludge water content reduced from 60.8% to 1.64%, showing the highest electrical conductivity and lowest organic matter content, making the humus substances abundant in the final product. Moreover, the vermicomposting achieved the highest ammonia and nitrate content in final product. Additionally, the bacterial and eukaryotic abundances in the VD product were significantly higher (P less then 0.01, i.e., 15.6% and 180.7%) than the vermicomposting product. The specific bacterial genus of Glutamicibacter, Chitinibacter, and Acidobacteria was dominated in the VD product. The Partial least squares-Path modeling (PLS-PM) results revealed that the maturity degree in the VD product was significantly associated with microbial component, and the organic form was strongly driven by the change in the physicochemical properties, which was contradictory to vermicomposting model. The study suggests that the VD process could shorten the vermicomposting period by rapidly accelerating the physical, chemical, and biological stabilization of sludge.Management and safe disposal of chrome-tanned leather wastes generated in leather industry are of great importance due to their potential health risks and environmental hazards. Herein, an integrated strategy was proposed for disposing of chrome-tanned leather scrap (CTLS). This method involves the separation of chromium salts from CTLS with sulfuric acid for recycling purpose, followed by pyrolysis of the acid-treated CTLS in an inert atmosphere. SEM/EDX analysis was employed to characterize the changes in composition and morphology of CTLS after acid treatment. CO2 and H2O are main pyrolysis gases of CTLS, while the acid treatment increases the relative content of aliphatic hydrocarbons and NH3 in evolved gases. The pyrolysis characteristics and kinetics of the acid-treated CTLS were investigated by thermogravimetric analysis (TGA) at three different heating rates. After 3 and 6 days of acid treatment, the average activation energy of CTLS (450.9 kJ/mol) obtained from the Flynn-Wall-Ozawa method decreased to 369.6 and 351.0 kJ/mol, respectively. It is assumed that the CTLS consists of two pseudocomponents low-crosslinked collagen (LCol) and highly-crosslinked collagen (HCol). Using the generalized master plots method, random nucleation and nuclei growth model (An model) was found to be the most probable kinetic model for the pyrolysis process of LCol and HCol. The kinetic exponent for pseudocomponent pyrolysis varied between 3.00 and 3.90, and the pre-exponential factor ranged from 5.83 × 1012 to 2.93 × 1013 min-1. The results of the present study provide an alternative route and useful information for recycling and disposing of chrome-containing leather wastes.

To investigate and compare the immunoexpression of E-cadherin, α-SMA, TGF-β and Snail proteins between cases of actinic cheilitis (AC) and squamous cell carcinoma of the lower lip (LLSCC).

E-cadherin, α-SMA, TGF-β and Snail antibody immunostaining was analyzed semiquantitatively in 54 AC cases and in 49 LLSCCs. The cases were classified as low and high expression for analysis of the association with clinicopathological variables and overall survival (OS) and disease-free survival (DFS) rates.

High expression of E-cadherin (cytoplasmic) (p=0.001) and α-SMA (p<0.001) was identified in LLSCCs, as well as low expression of TGF-β in LLSCCs (p<0.001) and high expression of Snail in AC cases (p=0.006). Survival analysis revealed that high expression of α-SMA at the tumor invasion front, a network immunostaining pattern of this protein, and high expression of TGF-β in tumor buds were significantly associated with poor OS (p<0.05). There was a higher risk of death among LLSCC cases with high expression of α-SMA (HR = 5.