Dukehonore6956

ication. All other race/ethnicity groups had higher odds of cesarean compared with White women. Compared with White women, Black women had greater odds of fetal intolerance as an indication, while Hispanic and Asian women had greater odds of failure to progress. Maternal, neonate, and facility factors for cesarean delivery did not explain the observed disparities in cesarean delivery rates.

Race/ethnicity was significantly associated with the odds of cesarean and indication. All other race/ethnicity groups had higher odds of cesarean compared with White women. Compared with White women, Black women had greater odds of fetal intolerance as an indication, while Hispanic and Asian women had greater odds of failure to progress. Maternal, neonate, and facility factors for cesarean delivery did not explain the observed disparities in cesarean delivery rates.This study aimed to assess time to hepatitis C (HCV) treatment (i.e., the time between the initial clinic visit for HCV evaluation and the HCV treatment start date), to compare clinical characteristics between patients who received HCV treatment ≥ and less then 6 months, and to identify predictors of longer time to HCV treatment in patients living with HCV. This study conducted a retrospective secondary analysis of patients living with HCV mono-infection and HIV/HCV co-infection who received HCV treatment with DAAs (n=214) at a HIV Clinic. Binomial logistic regression was used to identify predictors of longer time to treatment (i.e., ≥ 6 months). The median time to HCV treatment was 211 days. Compared to patients who were treated less then 6 months, a higher proportion of patients who were treated ≥ 6 months had HIV/HCV co-infection (31% vs. 49%, p=0.01) and chronic kidney disease (8% vs. 18%, p=0.03). In multivariate analysis, HIV/HCV co-infection was positively associated with a longer time to HCV treatment (adjusted odds ratio, aOR=2.0, p=0.03). Time to HCV treatment disparities between African American and White American did not emerge from the analysis, but time to HCV treatment disfavored patients living with HIV/HCV co-infection. Studies are needed to identify and eliminate factors that disfavor patients living with HIV/HCV co-infection.

Breast cancer is the leading cause of cancer death among Hispanic women. Unfortunately, few studies disaggregate Hispanic patients by race to understand its implications on treatment and clinical outcomes such as mortality. The aim of this study is to examine surgical management and overall mortality among different subgroups of women who self-identify as Hispanic.

Hispanic female patients, ages 18-90, stages I-III, diagnosed with breast cancer between 2010 and 2015 from the National Cancer Data Base were identified. The study cohort was divided into three ethnoracial categories (1) Hispanic White (HW), 2) Hispanic Black (HB), and 3) Hispanic Other (HO). Descriptive statistics and multivariate models were constructed to determine the relationship between sociodemographic factors, clinical variables, surgical management, and mortality when disaggregated by race.

There were 56,675 Hispanic women who met the study criteria. Most where HW (n=50,599, 89.3%) and the rest were HB (n=1,334, 2.4%) and HO (n=4,74e are ethnoracial disparities in reconstruction utilization and mortality among Hispanic women. Future studies should examine how culture, language, healthcare access, and patient preferences contribute to these disparities.Listeners' perception of temporal contrasts in spoken language is highly sensitive to contextual information, such as variation in speech rate. The present study tests how rate-dependent perception is also mediated by distal (i.e., temporally removed) rhythmic patterns. In four experiments the role of rhythmic alternations and their interaction with speech rate effects are tested. Experiment 1 shows proximal speech rate (contrast) effects obtain based on changes in local context. Experiment 2 shows that these effects disappear with the addition of distal rhythmic alternations, indicating that rhythmic grouping shifts listeners' perception, even when proximal context conflicts. Experiments 3 and 4 explore how orthogonal variation in overall speech rate impacts these effects and finds that trial-to-trial (i.e., global) speech rate variation eliminates rhythmic grouping effects, both with and without variation in proximal (immediately preceding) context. Together, these results suggest a role for rhythmic patterning in listeners' processing of durational cues in speech, which interacts in various ways with proximal, distal, and global rate contexts.

Comprehensive geriatric assessment (CGA) has been used to help identify elderly patients with diffuse large B-cell lymphoma (DLBCL) who were suitable for rituximab combined with CHOP therapy (cyclophosphamide, Adriamycin, vincristine, and prednisolone), but there are few reports of CGA for elderly patients with DLBCL who received R-mini-CHOP.

We retrospectively analyzed the risk factors for outcomes among 142 patients aged 80years and older (≤ 85years, n = 102; > 85years, n = 40) with DLBCL who received R-mini-CHOP at 4-week intervals at our institute between 2008 and 2019. We performed a comparison between CGA and treatment outcomes.

There were significant differences in progression-free survival between patients with international prognostic index (IPI) scores of > 3 and ≤ 3 at diagnosis and in overall survival between patients with instrumental activities of daily living (IADL) scores of ≥ 5 and IADL < 5 before the initial treatment and patients aged ≤ 85years and > 85years.

Strategies that carefully select elderly patients aged 80years and older with DLBCL using CGA may help to identify individuals suitable for novel therapies.

Strategies that carefully select elderly patients aged 80 years and older with DLBCL using CGA may help to identify individuals suitable for novel therapies.

Immunotherapy by checkpoint inhibitors, i.e., anti-programmed death-1(PD-1) or anti-programmed death-ligand 1 (PD-L1) antibodies, has gained more attention managing solid tumors. Pembrolizumab (an anti-PD-1 antibody) in metastatic colorectal cancer (CRC) was approved in 2017 by the US FDA.

Pembrolizumab is not effective in microsatellite stable, mismatch-repair-proficient (MSS-pMMR) molecular phenotype, which comprises most CRC patients. see more In this report, we present the first case of metastatic CRC with a dramatic and durable response to pembrolizumab despite being of MSS-pMMR phenotype. A 34-year-old woman, presented seven years ago with T3N2bM0 colon cancer and an appendix carcinoid tumor. The last relapse with bilateral pulmonary metastases was refractory to all treatments. Although it seemed unresponsive to immunotherapy because of MSS molecular phenotype, due to the high expression level of PD-L1 (85%), we started treatment with pembrolizumab 200mg every three weeks and continued for the overall 19 coun the current clinical trials, MSS-pMMR colorectal cancer patients' deprivation from immunotherapy seems not to be reasonable. There are ongoing clinical trials on checkpoint inhibitors either alone or in combination with other drugs. However, immunostaining for PD-L1 should be considered as a possible response predictor. Immunotherapy either by cell-based approaches or by checkpoint inhibitors may revolutionize cancer treatment Pembrolizumab has been approved by the FDA in 2017 for colorectal cancer. However, MSS-pMMR molecular phenotype which comprises the majority of CRC patients, has not shown a good response to checkpoint inhibitors. We present a MSS-pMMR case with complete and durable response to pembrolizumab We suggest immunostaining for PD-L1 as a possible response predictor to checkpoint inhibitors.Person names, which hold within them extensive meaning, such as gender and cultural information, play an essential role in our social interaction. The intentional memory advantage of person names has been proved, but whether the automatic memory advantage of them exists remains unclear. In order to explore this question, we used a paradigm called attribute amnesia that allows us to test the automatic memory of person names in a working memory task. In Experiment 1, we adopted a classic attribute amnesia paradigm including 11 pre-surprise trials requiring participants to report the location of the target (person names or animal names) among three distractors and one surprise trial requiring them to unexpectedly report the identity of the target. The results showed that the identity report accuracy of person names in the surprise test was significantly better than that of animal names that served as a control group. Experiment 2 replicated Experiment 1 but increased the number of pre-surprise trials that could reduce the report accuracy of surprise test according to previous studies. The results revealed that the accuracy of the surprise test of person names decreased significantly, and showed no significant difference from that of animal names. These results suggest that there exists an automatic memory advantage of person names in working memory; however, such an automatic memory advantage effect could be reduced after participants learn to stop automatically encoding the attended but no-need-to-report person names through experiencing sufficient trials.The practice of sequentially testing a null hypothesis as data are collected until the null hypothesis is rejected is known as optional stopping. It is well known that optional stopping is problematic in the context of p value-based null hypothesis significance testing The false-positive rates quickly overcome the single test's significance level. However, the state of affairs under null hypothesis Bayesian testing, where p values are replaced by Bayes factors, has perhaps surprisingly been much less consensual. Rouder (2014) used simulations to defend the use of optional stopping under null hypothesis Bayesian testing. The idea behind these simulations is closely related to the idea of sampling from prior predictive distributions. Deng et al. (2016) and Hendriksen et al. (2020) have provided mathematical evidence to the effect that optional stopping under null hypothesis Bayesian testing does hold under some conditions. These papers are, however, exceedingly technical for most researchers in the applied social sciences. In this paper, we provide some mathematical derivations concerning Rouder's approximate simulation results for the two Bayesian hypothesis tests that he considered. The key idea is to consider the probability distribution of the Bayes factor, which is regarded as being a random variable across repeated sampling. This paper therefore offers an intuitive perspective to the literature and we believe it is a valid contribution towards understanding the practice of optional stopping in the context of Bayesian hypothesis testing.

Proxy reports are often used when patients are unable to self-report. It is unclear how proxy measures are currently in use in adult health care and research settings. We aimed to describe how proxy reports are used in these settings, including the use of measures developed specifically for proxy reporting in adult health populations.

We systematically searched Medline, PsycINFO, PsycTESTS, CINAHL and EMBASE from database inception to February 2018. Search terms included a combination of terms for quality of life and health outcomes, proxy-reporters, and health condition terms. The data extracted included clinical context, the name of the proxy measure(s) used and other descriptive data. We determined whether the measures were developed specifically for proxy use or were existing measures adapted for proxy use.

The database search identified 17,677 possible articles, from which 14,098 abstracts were reviewed. Of these, 11,763 were excluded and 2335 articles were reviewed in full, with 880 included for data extraction.