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Objective To investigate the association between serum albumin levels and health-related quality of life in centenarians in Hainan province, China. Methods We conducted a full sample centenarian cohort study in a community population in Hainan from 2014 to 2016, which included 1 002 centenarians for questionnaire surveys, physical examinations and biological tests. The EQ-5D-VAS scale was used to evaluate health-related quality of life, and multiple linear regression and multiple logistic regression analyses were used to analyze the association between serum albumin levels and health-related quality of life. Results There was a positive linear relationship between serum albumin levels and EQ-5D/VAS score. The normalized β values in the fully adjusted model was 0.156 (P less then 0.001). Necrostatin 2 in vitro In the multivariate logistic regression analysis, after fully adjusting the covariates, the risk of health related life quality impairment in the lower albumin group was 2.369 times(95%CI 1.424-3.939) than that in the higher albumin group. Gender stratified analyses showed that the OR was 4.406 (95%CI 1.537-12.631) in male centenarians and 2.035 (95%CI 1.125-3.680) in female centenarians. Conclusion Lower serum albumin level was associated with impaired health-related quality of life in centenarians in Hainan.Objective To explore the prevalence of lipid profile and the influencing factors of dyslipidemia in centenarians in Hainan province, and provide basic data for the study of the lipid profile in centenarians. Methods The data of this study were from the baseline data of China Hainan Centenarian Cohort Study from June 2014 to December 2016. A total of 1 002 centenarians were recruited. According to the guidelines for the prevention and treatment of dyslipidemia in Chinese adults in 2016, the prevalence of lipid profile were described and the prevalence of dyslipidemia with different clinical classifications were compared, and the main influencing factors were analyzed. Results The median levels of TC, TG, LDL-C and HDL-C were 4.60 mmol/L, 1.05 mmol/L, 2.77 mmol/L and 1.41 mmol/L, respectively, in centenarians in Hainan. Blood lipid profile level was higher in females than in males. With the increase of BMI, TC, TG and LDL-C increased significantly, while HDL-C decreased significantly. The total prevalence of dyslipidemia was 19.1%. Smoking, BMI and area distribution were the main influencing factors of dyslipidemia. Conclusion The prevalence of dyslipidemia in centenarians in Hainan was at a low level compared with other countries, and the blood lipid profile level was higher in females than in males.Objective To explore the blood pressure levels and the influencing factors of hypertension among Hainan centenarians, and provide basic data for the further blood pressure related studies of the centenarian population. Methods The baseline data were from China Hainan Centenarian Cohort Study (CHCCS). This cross-sectional data, based on the community population, was a complete sample study of centenarians, including questionnaire survey, physical examination and physiological index detection. A total of 1 002 centenarians were recruited to describe the blood pressure level. According to the guidelines for the prevention and treatment of hypertension in Chinese adults in 2018, the prevalence of hypertension was analyzed. Results The median levels of systolic blood pressure, diastolic pressure and pulse pressure were 152.0, 76.0 and 76.5 mmHg, respectively. Blood pressure level was higher in females than in males. The prevalence of hypertension was 71.9%, mainly in isolated systolic hypertension with the prevalence of 60.1%. The results of multivariate analysis showed that the risk of hypertension in women was higher than that in men (OR=1.624, 95%CI 1.155-2.283), and the risk of hypertension in the northern (OR=0.625, 95%CI 0.434-0.901) and central areas (OR=0.586, 95%CI 0.346-0.993) was lower than that of the Eastern. Conclusion The prevalence of hypertension, mainly in isolated systolic hypertension, showing gender and regional distribution differences.Objective To investigate basic characteristics of diabetes prevalence and associated factors in centenarians in Hainan province of China. Methods All the subjects were from China Hainan Centenarian Cohort Study. A total of 1 002 centenarians were included in the final analysis, who were divided into three groups diabetes group, impaired fasting glucose (IFG) group, and normal glucose group according to the guideline. Results The average age of centenarians was (102.77±2.55) years, and the proportion of females was 82.0%. There were 95 centenarians who suffered from diabetes, and the prevalence rate was 9.5%. There were 81 centenarians who had IFG, and the prevalence rate was 8.1%. The mean fasting plasma glucose (FPG) level of centenarians was (5.12±1.44) mmol/L, while 43.5% of centenarians had FPG levels ranging from 4.00 to 5.00 mmol/L and 22.1% of centenarians had the FPG levels ranging from 5.00 to 6.00 mmol/L. Increased triglyceride level and abdominal obesity might be associated with the risk for diabetes. Conclusion The glycometabolism in centenarians in Hainan was better than that in other age groups, and no gender specific difference was observed.Clostridioides difficile is a key pathogen of antibiotic related diarrhea and hospital associated infection, causing several outbreaks in Europe and North Americans and resulting in severe disease burden. However, the standardized diagnostic principle and detection specifications in C. difficile infection (CDI) survey are limited in China, and the infection rate and disease burden of CDI in China are unclear. Therefore, National Institute for Communicable Disease Control and Prevention,National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, together with another 11 institutions, draft the group standard entitled "Diagnosis of Clostridium difficile infection (T/CPMA 008-2020)" of Chinese Preventive Medicine Association. Based on the principle of "legality, scientificity, advancement, and feasibility", this standard clarifies risk factors, diagnosis principles, diagnoses and differential diagnoses in order to improve the accuracy of CDI diagnosis in clinical practice, guide the surveillance for CDI, and understand the infection rate and disease burden of CDI in China.The studies on infectiousness of person infected with SARS-CoV-2 at different stages of illness are an important basis for making effective prevention and control measures such as investigating the infectious source, determining the scope of close contacts and the timing of case isolation. This review discusses the infectiousness of cases infected with SARS-CoV-2 in the incubation period, symptomatic period and convalescent period by reviewing national and international literatures, technical and professional guidelines. Existing researches suggest that the infectious viruses could be isolated at the end of the incubation period as well as since illness onset, and viral load in upper respiratory tract swabs reached the peak on day 4-6 after illness onset and thereafter began to decline, implying the infectiousness was relatively strong at the end of incubation period and within one week after illness onset. Although there were a few cases who tested positive for SARS-CoV-2 after recovery, no evidence was found to indicate these cases can cause the transmission.As the progress of population aging in China, the proportion of elderly population is increasing. Both chronic diseases and infectious diseases can threaten the health of the elderly. There are many kinds of infectious diseases, including vaccine preventable infectious diseases affecting the health of adults, such as influenza, pneumococcal diseases and herpes zoster. In addition, the newly emerged COVID-19 has caused a pandemic in the world, resulting the highest proportion of deaths occurred in the elderly and posing a serious threat to the health of the elderly. This paper mainly summarizes the prevention and control of vaccine preventable diseases and COVID-19 to which the elderly are susceptible, analyzes the infectious disease problems affecting the health of elderly population, and recommends countermeasures for the prevention and control of these diseases in elderly population.Hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) is the first cause of cancer-caused death in China. This study, from the perspective of HBV genomic epidemiology, systematically investigated the evolution of HBV and their interaction with host genetic factors in each stage of HBV carcinogenesis and comprehensively analyzed the role of apolipoprotein B mRNA editing enzyme catalytic polypeptides (APOBEC) family in the inflammation-to-cancer transformation. Based on our findings and related studies, we proposed "cancer evolution and development" (Cancer Evo-Dev) theoretical system suitable for most cancer types. Cancer Evo-Dev lays a theoretical foundation for understanding the mechanism of inflammation to promote the development of cancer, which is of great significance for the specific prevention, prediction, early diagnosis, and targeted therapy of malignant diseases.Recent years with the rapid progress in high-throughput omics techniques, the accumulation of population cohorts and biobanks, great advances in internet and information technology, and the emerging tools for big data utilization, health care big data provide abundant data resources and broad research platforms for epidemiological research. We aimed to review the opportunities and challenges of epidemiological research in the era of big data, and explore the future development of epidemiology. Epidemiology should seize the opportunities, open up new directions, develop new methods, and promote the translation of research results into public health and clinical medicine, which will eventually realize the vision of "Healthy China".One of the main aims of chronic disease epidemiology is to explore the etiological factors of diseases. Multi-omics includes all genes (genomics), extensive changes in gene expression (epigenetics), ribonucleic acids (transcriptomics), and proteins (proteomics) generated during the process of DNA replication, transcription, translation, and post-translational modification, as well as small molecule metabolites downstream (metabolomics). Multi-omics platforms provide technical support for assessing omics biomarkers including genomics, transcriptomics, and proteomics, while systems epidemiology provides theoretical and methodological support for using multi-omics to conduct etiological research. Multi-omics research not only reveals the interaction network between molecules, but also contributes to causal inference from the molecular level. With the global exponential growth of publicly available data, analysis platforms, and consortia, resources for multi-omics research will become more abundant, and the depth and breadth of research will be greatly expanded. This article will review the applications of multi-omics approach in the etiologic research on non-communicable diseases, representative research in the past three years, opportunities and challenges for large-scale cohort studies, advantages and issues of multi-omics research in the Chinese population, and future perspectives.