Molinadonaldson0394
Breast cancer survivors are at increased risk of adverse outcomes, called late effects, years after the completion of active treatment. Late effects can significantly impair physical functioning. The current study aimed to explore breast cancer survivors' experiences of late effects, their emotional responses to existing or potential late effects and their perceived impact.
A total of 36 women treated for breast cancer in the last 10years participated in semi-structured telephone interviews. Participant views were sought with respect to knowledge, experience, and perceived longer-term risk. A thematic analysis was conducted.
Four themes emerged from the data (1) late effects awareness, (2) framing and coping, (3) uncertainty and (4) management. There was a range of emotional responses to late effects; however, many participants reported being unaware of their risk of late effects. Participants conceptualised late effects as any long-term effect of treatment regardless of the time of onset. Women reported living with constant uncertainty and feared cancer recurrence. Many were focused on managing long-term treatment side effects, rather than late effects.
Many women undergo treatment and remain unaware of associated late effect risks. National guidelines recommend patients be informed about late effects; however, the results of this study suggest a gap between policy and practice. Evidence-based interventions are needed to equip women with strategies to physically and emotionally manage late effects.
Many women undergo treatment and remain unaware of associated late effect risks. National guidelines recommend patients be informed about late effects; however, the results of this study suggest a gap between policy and practice. Evidence-based interventions are needed to equip women with strategies to physically and emotionally manage late effects.Venous blood is a preferred matrix for the determination of total mercury (Hg) in human biomonitoring but has some drawbacks such as the requirement for an uninterrupted cold chain for transport and storage and the need of medical personnel for sample collection. Therefore, we tested and implemented a simpler and less expensive method for measuring Hg in human blood using dried blood spots (DBS). For method development, we investigated the influence of different storage conditions (temperature, storage vessel, time) on DBS samples. For method validation, we compared DBS and venous blood and investigated whether DBS sampling is suitable for measuring Hg in the general population in countries with low Hg exposure such as Germany. Based on our results, we found that pre-cleaned glass tubes were most suitable for storage of DBS samples, as this allowed the samples to remain stable for at least 4 weeks even at high temperatures (40 °C). When comparing venous blood and DBS, a very good correlation (r = 0.95, p less then 0.01, Spearman-Rho) and high precision of DBS (mean relative standard deviation 8.2% vs. this website 7.2% in venous blood samples) were observed. Comparing the recoveries of both matrices in different concentration ranges, the variation of the recoveries decreases with increasing Hg concentration. The mean recoveries also decreased with increasing Hg concentration. Overall, we found comparable results for DBS and venous blood using direct Hg analysis. Furthermore, we demonstrated that DBS are suitable for Hg biomonitoring in the general population in Germany and improved the storage conditions for the DBS.Twenty years ago, the first members of the genus Burkholderia capable of nodulating and fixing N2 during symbiosis with leguminous plants were reported. The discovery that β-proteobacteria could nodulate legumes represented a breakthrough event because, for over 100 years, it was thought that all rhizobia belonged exclusively to the α-Proteobacteria class. Over the past 20 years, efforts toward robust characterization of these bacteria with large-scale phylogenomic and taxonomic studies have led to the separation of clinically important and phytopathogenic members of Burkholderia from environmental ones, and the symbiotic nodulating species are now included in the genera Paraburkholderia and Trinickia. Paraburkholderia encompasses the vast majority of β-rhizobia and has been mostly found in South America and South Africa, presenting greater symbiotic affinity with native members of the families Mimosoideae and Papilionoideae, respectively. Being the main center of Mimosa spp. diversity, Brazil is also known as the center of symbiotic Paraburkholderia diversity. Of the 21 symbiotic Paraburkholderia species described to date, 11 have been isolated in Brazil, and others first isolated in different countries have also been found in this country. Additionally, besides the symbiotic N2-fixation capacity of some of its members, Paraburkholderia is considered rich in other beneficial interactions with plants and can promote growth through several direct and indirect mechanisms. Therefore, these bacteria can be considered biological resources employed as environmentally friendly alternatives that could reduce the agricultural dependence on agrochemical inputs.
To assess the whitening efficiency and patient satisfaction after usage of commercially available toothpastes with the different whitening ingredients.
This randomized controlled trial study comprised 161 participants who were randomly divided into eight groups based on used whitening or control/conventional toothpaste (Colgate Max Expert White [CMEW], n = 20; Signal Daily White [SDW], n = 20; Himalaya Sparkly White Herbalis [HSWH], n = 20; Signal White System [SWS], n = 20; Rembrandt Deeply White + Peroxide [RDWP], n = 20; Splat Extreme White [SEW], n = 20; Splat White Plus [SWP], n = 21; and Kalodont Multi Repair [control], n = 20). Tooth color and color change were evaluated using a spectrophotometer (CIELAB coordinates, ΔE
*, ΔE
, whiteness index change [ΔWID]). Measurements were performed at baseline, 30days and 60days after the beginning of treatment, and 30days after completing treatment - follow-up. Side effects and satisfaction with the whitening outcome were reported throughout the questionnaire.
The results for ΔL*, Δa*, and Δb* showed an increase in lightness and decrease in yellowness for all tested whitening toothpastes compared to the control group after 30days of use (p ≤ 0.05). Also, significant tooth color difference (ΔE
*, ΔE
) and whiteness index change (ΔWI
) were recorded for all tested whitening toothpastes 30days and 60days from the beginning of use (p ≤ 0.05). Toothpaste containing a combination of urea peroxide and enzyme ingredients (SEW) demonstrated the highest and the longest whitening effect.
Whitening toothpastes can show perceptibly whitening effect after a short time of usage, but without a long-lasting impact.
Toothpaste containing a combination of enzymes and peroxides showed the best whitening performance compared to those containing only enzymes, peroxides, or abrasives.
ClinicalTrials.gov NCT04460755.
ClinicalTrials.gov NCT04460755.
Our aim was to investigate prospective associations of consumption of total dairy and dairy types with incident prediabetes in a Dutch population-based study.
Two enrolment waves of the Hoorn Studies were harmonized, resulting in an analytic sample of 2262 participants without (pre-) diabetes at enrolment (mean age 56 ± 7.3years; 50% male). Baseline dietary intake was assessed by validated food frequency questionnaires. Relative risks (RRs) were calculated between dairy, fermented dairy, milk, yogurt (all total/high/low fat), cream and ice cream and prediabetes. Additionally, substituting one serving/day of dairy types associated with prediabetes with alternative dairy types was analysed.
During a mean 6.4 ± 0.7years of follow-up, 810 participants (35.9%) developed prediabetes. High fat fermented dairy, cheese and high fat cheese were associated with a 17% (RR 0.83, 95% CI 0.69-0.99, p
= 0.04), 14% (RR 0.86, 95% CI 0.73-1.02, p
= 0.04) and 21% (RR 0.79, 95% CI 0.66-0.94, p
= 0.01) lower risk of inurated fatty acids and sodium.Sheep production is traditional for rural communities in Mexico, based on natural grasslands and semi-stabled feeding. Quality forages are necessary to improve productivity in these systems. Weeds are an alternative to feed ruminants and to manage crops. Also, many plants have secondary metabolites beneficial for livestock. The objective was to assess the nutritive value in vitro and the antioxidant activity of three weeds (Tithonia tubiformis, Cosmos bipinnatus, and Tagetes lucida) and four treatments (T0 = control diet, T1 = diet + 5% T. tubiformis, T2 = diet + 5% C. bipinnatus, and T3 = diet + 5% T. lucida). Nutritive value was determined from chemical composition by standard methods and mineral contents by inductively coupled plasma analyses. Secondary compounds, total phenols (TP), total tannins (TT), condensed tannins (CT), and phenolic compounds, were determined by high-performance liquid chromatography, and total antioxidant activity was determined by measuring the oxygen radical absorbance capacity. Rumen fermentation kinetics and in vitro digestibility of dry matter (IVDMD), organic matter (IVOMD), and neutral detergent fibre (IVNDFD) were determined per species and treatment by in vitro gas production. T. tubiformis had the highest CP and TP contents (P 0.05) were found in rumen kinetics parameters, IVDMD, IVOMD, IVNDFD, or metabolizable energy, indicating that the tested weeds can be used as additives to increase antioxidant activity in sheep diets without negative effects.
Indocyanine green (ICG) and sodium fluorescein (SF) are fluorescent dyes used for sentinel lymph node mapping. In oncological gastric surgery, ICG lymphography has increased the number of resected lymph nodes. However, the optimal time to administer ICG is unclear, and both preoperative and intraoperative injections have been practised. As dye spillage will diminish lymphogram visibility, a second dye with different excitation and emission spectra may present a clinical alternative. We measured the time until maximum ICG fluorescence of gastric sentinel lymph nodes and investigated the feasibility of combined lymphography with two fluorescent dyes ICG and SF.
Ten Danish Landrace/Yorkshire pigs were used in this study. After completion of the laparoscopic setup, ICG and then SF were endoscopically injected into the gastric submucosa. Lymphograms for both dyes were recorded, and the time until maximum ICG sentinel lymph node fluorescence was determined.
The mean time until maximum ICG fluorescence of gaste two dyes. The ability to use multiple dyes during a surgical procedure offers the exciting prospect of simultaneously assessing perfusion and performing fluorescence lymphography.
This study aimed to examine the morphometry of the crista galli (CG) on paranasal sinus computed tomography (PNCT) images to develop a new approach of morphological classification with objective radiological criteria and to investigate the relationship of morphometric and morphological characteristics with gender.
The height, width, and length of the CG were measured on the PNCT images of 533 subjects (266 males, 267 females). Based on the dimensions and the presence of the cavitary component of the CG, the CG was classified into three morphological types. The success of CG dimensions and new morphological classification of CG in the determination of gender was evaluated with ROC and Paired Logistic Regression analyses.
The morphometric cutoff values of the height, width, and length of the CG for the estimation of gender were determined as 15.15, 3.45, and 13.25mm, respectively. CG length (accuracy 83.7%) showed more successful classification rate on gender determination as compared to height (accuracy 81.
