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lly with various planned infrastructural developments around the lakeshore.Contact lens-associated keratitis is becoming increasingly more frequent. Fungal keratitis is a relatively rare clinical picture but must be taken very seriously. Especially in the early stages of the disease, it may be clinically misdiagnosed and adequate treatment is therefore delayed. In treatment-resistant contact lens-associated fungal keratitis, coinfections or superinfections can occur. We present two patients with an initially unclear keratitis, in whom a fungal keratitis with coinfection of Pseudomonas aeruginosa and Acanthamoeba, respectively, could be confirmed. In both cases an urgent excimer laser penetrating keratoplasty with interrupted sutures and adequate local topical treatment for 8 weeks was successful.

The therapy strategy of patients with acute stroke of the middle cerebral artery (MCA) is influenced by the location of the occlusion. The purpose of this study was to analyze the clinical outcome in patients with acute ischemic MCA occlusion according to the location of occlusion who underwent endovascular treatment (EVT).

A total of 54patients (age 73 ± 15years; 59% female) with acute ACM occlusion treated with EVT were included. In coronary reformatted CT angiography images, the distance to the thrombus (DT), i.e. the distance from the carotidT to the beginning of the thrombus, was measured. Correlations between DT, clinical symptoms, and clinical outcome of patients who underwent EVT were analyzed.

DT correlated with clinical symptoms measured by the National Institutes of Health Stroke Scale (NIHSS; p = 0.017; R = -0.324) at baseline. DT also correlated with the modified Rankin scale after 90days (90-day mRS; p = 0.014; R = -0.333). DT was apredictor for agood clinical outcome (mRS after 90days) after EVT; odds ratio 1.113 (P = 0.02; 95% confidence interval [CI] 1.017-1.219). ADT >10 mm correlated significantly (p = 0.036) with agood clinical outcome (90-day mRS ≤2).

DT correlates with the clinical symptoms of patients with acute MCA occlusion. In addition, DT is an independent predictor of the clinical outcome of patients suffering from acute stroke due to MCA occlusion.

DT correlates with the clinical symptoms of patients with acute MCA occlusion. In addition, DT is an independent predictor of the clinical outcome of patients suffering from acute stroke due to MCA occlusion.

Health literacy (HL) is regarded as akey determinant in health promotion. The support of HL should begin as early as possible to prevent later health problems. In the school setting, teachers play an important role. Due to all-day school and inclusion efforts, teachers are increasingly faced with the health problems of pupils. At the same time, many teachers show their own significant health problems, often due to an enormous workload.

This study assesses the level of the individual teacher's HL and examines possible relationships between the individual HL of teachers and their level of uncertainty in dealing with chronically ill pupils.

Asecondary data analysis of aquantitative survey of n = 420 teachers was conducted. Aself-assessment of the teacher's HL level was done using HLS-EU-Q16. Furthermore, correlation analyses between the HL and the level of insecurity of teachers in dealing with selected health problems were made.

More than half of the teachers showed alimited level of HL and an association between low level of HL and uncertainty in dealing with chronically ill pupils were found. In particular, mental health issues caused difficulties among the teachers.

There is alarge gap between complex health-related demands on the teachers and their required health literacy as well as sovereignty in dealing with chronic and mental impairments in the school setting. These deficits will influence the children's HL and the health development of adolescents.

There is a large gap between complex health-related demands on the teachers and their required health literacy as well as sovereignty in dealing with chronic and mental impairments in the school setting. These deficits will influence the children's HL and the health development of adolescents.

Despite the widespread use of UDI-6 and ICIQ-UI SF in Croatia, it remains unknown whether a realiable and valid measure for the population of interest is used. Thus, the aim of this study was to translate, adapt and validate the UDI-6 and the ICIQ-UI SF in Croatia.

The study included a total of 232 consecutive patients with urinary incontinence symptoms. The translation to Croatian followed standardized procedure. All participants underwent urodynamic assesment and completed UDI-6 and ICIQ-UI SF questionnaires at inclusion and 2weeks after to assess test-retest reliability. Cronbach α coefficient was calculated in order to assess internal consistency.

Both questionnaires had high internal consistency (Cronbach α for UDI-6 and ICIQ-UI SF was .83 and .85, respectively) and high test-retest reliability (intraclass correlation coefficient .99 for instruments). Strong correlation was found between urodynamic findings and total scores in UDI-6 and ICIQ-UI SF (ρ = 0.88 and 0.89, respectively). Women with stress urinary incontinence (SUI) and detrusor overactivity (DOA) group had significantly higher scores on UDI-6 (Mdn = 33.33 and Mdn = 50, respectively) compared to women with no urodynamic abnormality (Mdn = 0; p< 0.001). Women with no urodynamic abnormality scored significantly lower on ICIQ-UI SF (Mdn = 0; p < 0.001) compared to women with SUI (Mdn = 14) and DOA (Mdn = 16). Women with DOA scored worse on Irritative and Obstructive symptoms when comparing with two other groups (p< 0.001), while women with SUI had significantly worse score on Stress symptoms subscale (p < 0.001).

The UDI-6 and ICIQ-UI SF have very good psychometric characteristics and can be used in Croatian urogynecology practice.

The UDI-6 and ICIQ-UI SF have very good psychometric characteristics and can be used in Croatian urogynecology practice.

With conventional MRI, it is often difficult to effectively differentiate between contrast-enhancing brain tumors, including primary central nervous system lymphoma (PCNSL), high-grade glioma (HGG), and metastasis. This study aimed to assess the discrimination ability of the parameters obtained from DWI and the percentage signal recovery- (PSR-) optimized protocol of DSC-MRI between these three tumor types at an initial step.

DSC-MRI using a PSR-optimized protocol (TR/TE = 1500/30 ms, flip angle = 90°, no preload) and DWI of 99 solitary enhancing tumors (60 HGGs, 24 metastases, 15 PCNSLs) were retrospectively assessed before treatment. rCBV, PSR, ADC in the tumor core and rCBV, and ADC in peritumoral edema were measured. The differences were evaluated using one-way ANOVA, and the diagnostic performance was evaluated using ROC curve analysis.

PSR in the tumor core showed the best discriminating performance in differentiating these three tumor types with AUC values of 0.979 for PCNSL vs. others and 0.947 before the CBV-optimized protocol.

Acute kidney injury (AKI) is acommon and serious complication of acute life-threatening diseases.

The aim of this study was to investigate the effect of acute renal failure on mortality in intensive care patients, the need for renal replacement therapy at discharge, and the effect on long-term mortality.

Evaluation of 118 patient cases with dialysis-dependent acute renal failure between November 2016 and December 2017 admitted to amedical intensive care unit (ICU) at the University Hospital Tübingen, Germany. Dialysis at discharge and 1‑year mortality were defined as the primary endpoints. The secondary endpoint was need for continuous renal replacement after 18months.

In 118 patients, renal replacement modality by means of hemodialysis became necessary. Amortality rate of 45.8% (54/118) was found in patients requiring dialysis. Of the 64 surviving dialysis-dependent patients, 35.9% were still dependent on renal replacement therapy at the time of discharge. The 1‑year mortality rate was significantly higher in patients that still required dialysis at the time of discharge (p = 0.004). At 18-month follow-up, seven patients (10.9%) were still on renal replacement therapy. At this time, dialysis was significantly more frequent in patients with dialysis at the time of discharge than in dialysis-free patients (7.1% vs. 71.4%, p = 0.001).

Severe episodes of AKI requiring renal replacement therapy in the setting of an ICU are associated with increased mortality 1year after discharge and an increased requirement for renal replacement 18months after discharge.

Severe episodes of AKI requiring renal replacement therapy in the setting of an ICU are associated with increased mortality 1 year after discharge and an increased requirement for renal replacement 18 months after discharge.The Pars Special Economic Energy Zone (PSEEZ) is one of the largest gas reserves in the world. To reduce the CO2 emission from the area in line with the international climate commitments, two groups of scenario have been developed the first is using the ecosystem services of mangrove forests, and the second is technology development for oil and gas industries. For the first scenario, the carbon sequestrated by the trees was calculated using the allometric equation, and the carbon of sediments was determined by using the Walkley-Black method. For the second scenario, CO2 emitted from the PSEEZ was calculated by using the Iranian Petroleum Ministry Guidelines. CO2 emission from the PSEEZ was 0.030 Gt year-1. The maximum CO2 sequestered by mangrove scenarios was 0.12% of the PSEEZ emissions, while the flaring elimination technology reduces 36% of the PSEEZ emissions. Generally, the scenario of using oil and gas industry technologies is more effective.

Accurate intraoperative assessments of tissue perfusion are essential in all forms of surgery. As traditional methods of perfusion assessments are not available during minimally invasive surgery, novel methods are required. Here, fluorescence angiography with indocyanine green has shown promising results. However, to secure objective and reproducible assessments, quantification of the fluorescent signal is essential (Q-ICG). This narrative review aims to provide an overview of the current status and applicability of Q-ICG for intraoperative perfusion assessment.

Both commercial and custom Q-ICG software solutions are available for intraoperative use; however, most studies on Q-ICG have performed post-operative analyses. Q-ICG can be divided into inflow parameters (ttp, t0, slope, and T

max) and intensity parameters (Fmax, PI, and DR). The intensity parameters appear unreliable in clinical settings. In comparison, inflow parameters, mainly slope, and T

max have had superior clinical performance.

Intraoperative Q-ICG is clinically available; however, only feasibility studies have been performed, rendering an excellent usability score. Q-ICG in a post-operative setting could detect changes in perfusion following a range of interventions and reflect clinical endpoints, but only if based on inflow parameters. Thus, future studies should include the methodology outlined in this review, emphasizing the use of inflow parameters (slope or T

max), a mass-adjusted ICG dosing, and a fixed camera position.

Intraoperative Q-ICG is clinically available; however, only feasibility studies have been performed, rendering an excellent usability score. learn more Q-ICG in a post-operative setting could detect changes in perfusion following a range of interventions and reflect clinical endpoints, but only if based on inflow parameters. Thus, future studies should include the methodology outlined in this review, emphasizing the use of inflow parameters (slope or T1/2max), a mass-adjusted ICG dosing, and a fixed camera position.