Hsustampe8652

It is concluded that there can be opportunities and benefits from adopting this new mindset, in order to complement existing approaches.Pedestrian deaths constitute 23% of road traffic deaths globally. Although several research papers have contributed to pedestrian safety analysis, they did not provide a comprehensive overview of the progress in the research domain and publication trends. This makes it difficult to identify trends and insights into the pedestrian research domain in light of the voluminous number of papers. This study fills this gap with a scientometric analysis of research on pedestrian safety analysis indexed in the Web of Science. The scope covers 2594 papers published between 2010 and 2021 in English. This study analyzed the annual publications and citation trends, top ten most cited papers, influential papers in their first three years after publication, contributing authors, funding agencies, and contributing journals. The regional gaps between the proportion of pedestrian deaths and research were also analyzed. The results showed low research productivity from low and middle-income countries although they have a high incidence of pedestrian deaths. Subsequently, the main keyword clusters or frontier topics were identified and topic analysis was employed to identify the evolution of studies. Four keyword clusters were identified, i.e., "vehicle-to-pedestrian crash and injury severity analysis", "pedestrian movement and decision simulation experiments", "improving the vehicle system towards reducing body region impact injuries", "pedestrian behavior in crosswalks and signalized intersections". This study contributes an integrated knowledge map of pedestrian safety analysis, publication trends, the evolution of studies, and under-researched topics to guide future research work in pedestrian safety analysis.We mapped the left hemisphere cortical regions and fiber bundles involved in picture naming in adults by integrating task-based fMRI with dMRI tractography. We showed that a ventral pathway that "maps image and sound to meaning" involves the middle occipital, inferior temporal, superior temporal, inferior frontal gyri, and the temporal pole where a signal exchange is made possible by the inferior fronto-occipital, inferior longitudinal, middle longitudinal, uncinate fasciculi, and the extreme capsule. A dorsal pathway that "maps sound to speech" implicates the inferior temporal, superior temporal, inferior frontal, precentral gyri, and the supplementary motor area where the arcuate fasciculus and the frontal aslant ensure intercommunication. This study provides a neurocognitive model of picture naming and supports the hypothesis that the ventral indirect route passes through the temporal pole. This further supports the idea that the inferior and superior temporal gyri may play pivotal roles within the dual-stream framework of language.Entoptic phenomena are visual artifacts arising from the interaction of light with the specific anatomic structure of the human eye. While they are usually too subtle to actually enable additional visual abilities, their perception can provide indirect information on the physiological conditions of the visual system. Among the most famous ones, Haidinger's brushes consist in the appearance of a yellowish bow tie perceived in the presence of linearly polarized white light and originate from the particular spatial distribution of dichroic carotenoid molecules forming a sort of embedded radial polarizer in the foveal region. In this work, we develop a compact and versatile optical setup for the psychophysical analysis of the perceptual threshold of such entoptic effect. The tests performed on a group of 113 healthy individuals under conditions of maximum contrast (blue light) reveal the capability to perceive an average polarization degree around 16%. The developed prototype outlines a new optical platform to train the users in the perception of the phenomenon and infer information on the polarization-degree sensitivity of the human visual system.With the widespread use of volatile anesthetic agents in the prolonged sedation for COVID-19 pneumonia and ARDS, there is an urgent need to investigate the effects and treatments of lengthy low-concentration inhaled anesthetics exposure on cognitive function in adults. Previous studies showed that general anesthetics dose- and exposure length-dependently induced neuroinflammatory response and cognitive decline in neonatal and aging animals. The anti-diabetes drug metformin has anti-neuroinflammation effects by modulating microglial polarization and inhibiting astrocyte activation. In this study, we demonstrated that the inhalation of 1.3% isoflurane (a sub-minimal alveolar concentration, sub-MAC) for 6 h impaired recognition of novel objects from Day 1 to Day3 in adult mice. Prolonged sub-MAC isoflurane exposure also triggered typically reactive microglia and A1-like astrocytes in the hippocampus of adult mice on Day 3 after anesthesia. In addition, prolonged isoflurane inhalation switched microglia into a proinflammatory M1 phenotype characterized by elevated CD68 and iNOS as well as decreased arginase-1 and IL-10. Metformin pretreatment before anesthesia enhanced cognitive performance in the novel object test. The positive cellular modifications promoted by metformin pretreatment included the inhibition of reactive microglia and A1-like astrocytes and the polarization of microglia into M2 phenotype in the hippocampus of adult mice. In conclusion, prolonged sub-MAC isoflurane exposure triggered significant hippocampal neuroinflammation and cognitive decline in adult mice which can be alleviated by metformin pretreatment via inhibiting reactive microglia and A1-like astrocytes and promoting microglia polarization toward anti-inflammatory phenotype in the hippocampus.Drug abuse/misuse is now a major global problem affecting public health as well as economic and social stability. This study presents a retrospective view of the prevalence of drugs in hair. Reasons for hair testing include the need for law enforcement to test suspicious individuals and the need for employers in specific industries to test their employees. Toxicology analysis results were reviewed for a total of 19,275 hair samples requested for drug abuse/misuse analysis at the Academy of Forensic Science over 29 months from February 2019 to June 2021. Drugs and their metabolites in hair samples were analyzed by liquid chromatography - tandem mass spectrometry. In the study, the 19,275 hair samples were screened for a total of 62 illegal drugs, which were divided into three categories illegal-drugs (I), medication (II), and new psychoactive substances (III). These three categories contain 11, 29 and 22 drugs respectively. In these hair samples, 4852 (25.2 %) tested positive for one or more drugs. Among them, the positive rate of category I was the highest (48.7 %), followed by category II (28.5 %), and category III (22.7 %). Over all, the positive rate of male users (26.2 %) was higher than that of female users (23.7 %), and most of them were young people (25-44 years old). Illegal-drugs (morphine, etc.) had the highest positive rate. Under the influence of some certain factors, the drug abuse situation will also undergo corresponding changes. The results can provide a scientific knowledge database which can help in the prevention of drug abuse.Tire marks are an important type of forensic evidence as they are frequently encountered at crime scenes. When the tires of a suspect's car are compared, the evidence can be very strong if so-called 'acquired features' are observed to correspond. When only 'class characteristics' such as parts of the tire pattern are observed to correspond, it is obvious that many other tires will exist that also correspond, and so this evidence is usually considered very weak or is simply ignored. Like Benedict et al. (2014) we argue that such evidence can still be strong and should be taken into account. We describe a method for assessing the evidential strength of a set of corresponding class characteristics by presenting a case example from the Netherlands in which tire marks were obtained. Only part of two different tire patterns were visible, in combination with measurements on the axes width. Suitable databases were found already existing and accessible to forensic experts. We show how such data can be used to quantify the strength of evidence and how it can be reported. We also show how the risk of bias due to information surrounding the case may be minimized in cases like this. Our 'blind' procedure enables the expert to report a correspondence between class features in a more convincing way than standard procedures allow. In the particular exemplar case quite strong evidence was obtained, which was accepted and used by the Dutch court. We generalize this procedure for quantifying the evidential value of an expert's opinion of a correspondence. This examination procedure can be applied directly to other types of pattern evidence such as shoeprints, fingerprints, or images. Furthermore, it is 'blind' in the sense that the risk of contextual bias is minimized.

Aquatic exercise therapy is used for the treatment and management of chronic low back pain (CLBP). However, to the authors' knowledge, no studies to date have compared muscle activity between different aquatic exercises performed by people with CLBP. As such, this study assessed and compared muscle activity, pain, perceived exertion and exercise intensity between different rehabilitative aquatic exercises.

Cross-sectional.

A 25-m indoor swimming pool within a university building.

Twenty participants with non-specific CLBP.

Twenty-six aquatic exercises in shallow water (1.25-m depth). Muscle activity was quantified bilaterally for the erector spinae, multifidus, gluteus maximus and medius, rectus abdominis, and external and internal obliques.

Mean and peak muscle activity, pain (visual analogue scale), perceived exertion (Borg scale) and exercise intensity (heart rate).

Hip abduction/adduction and extension/flexion exercises produced higher activity for gluteal muscles. Variations of squat exercieek to implement progression in effort and muscle activity, variation in exercise type, and may wish to target or avoid particular muscles. CONTRIBUTION OF THE PAPER.

No meta-analysis has analysed efficacy and safety of semaglutide in metabolic-dysfunction associated fatty-liver disease (MAFLD).

Electronic databases were searched for RCTs involving people with MAFLD and/or type-2 diabetes (T2DM) receiving semaglutide. Primary outcome was to evaluate changes in alanine aminotransferase (ALT). Secondary outcomes were to evaluate alterations in other measures of NAFLD, glycaemia, lipids and adverse-events.

Data from 4 RCTs (2115 patients) was analysed. A greater lowering with injectable semaglutide 0.4mg/0.5mg once weekly was seen with regards to ALT [MD -3.89U/L (95%CI-5.41 to-2.36); P<0.01; I

=0%; 2050 patients], liver stiffness (fibroscan®) [MD -3.19kPa (95%CI-3.26 to-3.12); P<0.01; 162 patients], steatosis [MD -13.40dB/m (95%CI 20.56 to-6.24); P<0.01; 162 patients], triglycerides [MD -21.43mg/dl (95% CI 41.63 to-1.23); P=0.04; I

=99%; 2050 patients], total cholesterol [MD -5.53mg/dl (95% CI-8.45 to-2.61); P<0.01; I

=0%; 1888 patients], LDL-cholesterol [MD -3.