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Pediatric interventional radiology has grown as an advanced subspecialty with increased demand, number and complexity of cases, and number of pediatric institutions offering a pediatric interventional radiology service. Despite the overall increase in the number of pediatric interventionalists over the past two decades, there is a heterogeneity in their academic backgrounds and a lack of uniform training pathways.
To analyze the demographics, academic backgrounds and scholarly activities of pediatric interventionalists across the United States (U.S.) and Canada.
A list of all members of the Society for Pediatric Interventional Radiology was obtained and pediatric interventionalists at academic and private practice institutions in the U.S. and Canada were included. Publicly available online sources were used to gather demographic and educational information about each pediatric interventionalist, which included the online curriculum vitae, the HealthGrades.com and Doximity.com websites, and Elsevier's Scschools.
Pediatric interventionalists in North America are predominantly male, with about a quarter having graduated from international medical schools. Pediatric radiology fellowship, followed by pediatric interventional radiology fellowship, was the most frequently pursued training pathway.
Pediatric interventionalists in North America are predominantly male, with about a quarter having graduated from international medical schools. Pediatric radiology fellowship, followed by pediatric interventional radiology fellowship, was the most frequently pursued training pathway.This case report of a 14-year-old boy with arthralgia and clinically suspected inflammatory arthropathy highlights how magnetic resonance imaging (MRI) ultimately diagnosed skeletal dysplasia. A genetic evaluation revealed a transient receptor potential vanilloid 4 (TRPV4) pathogenic variant. This is a rare description of the MRI appearance of this type of dysplasia in long bone epiphyses corresponding with the histological findings of disrupted endochondral ossification. This report offers imaging support to the description of endochondral bone growth disruption in TRPV4-related skeletal dysplasias.Neonatal hemochromatosis is a rare condition that causes neonatal liver failure, frequently resulting in fetal loss or neonatal death. It is thought that most cases of neonatal hemochromatosis are caused by gestational alloimmune liver disease (GALD), with neonatal hemochromatosis being a phenotype of GALD rather than a disease process. Extrahepatic siderosis in the pancreas, myocardium, thyroid and minor salivary gland is a characteristic feature of neonatal hemochromatosis. There is also sparing of the reticuloendothelial system with no iron deposition in the spleen. Hepatic and extrahepatic siderosis seen in neonatal hemochromatosis is from iron dysregulation secondary to liver damage rather than iron deposition causing the liver damage. The presence of extrahepatic siderosis in the pancreas and thyroid is diagnostic of neonatal hemochromatosis and can be detected noninvasively by multi-echo gradient recalled echo (GRE) T2*-weighted sequence of MRI within hours of birth. This helps to expedite the treatment in the form of intravenous immunoglobulin and exchange transfusion, which improves the survival in these babies. The finding of hepatic siderosis is nonspecific and does not help in the diagnosis of neonatal hemochromatosis because it is seen with other causes of advanced liver disease.In the context of pediatric cross-sectional imaging, the risk of ionizing radiation for CT and the potential adverse effects associated with sedation/anesthesia for MRI continue to provoke lively discussions in the pediatric literature and lay press. This is particularly true for issues relating to the risks of ionizing radiation for CT, which has been a topic of discussion for nearly two decades. In addition to understanding these potential risks and the importance of minimizing individual pediatric patient exposure to ionizing radiation, it is equally important for radiologists to be able to frame these risks with respect to the potential for adverse outcomes associated with the use of anesthesia for cross-sectional imaging in the pediatric population. Notably, before such risks can be estimated and compared, one should always consider the potential utility of each imaging modality for a given diagnosis. If one cross-sectional imaging modality is likely to be far superior to the other for a specific clinical question, every effort must be made to safely image the child, even if sedation/anesthesia is required.
This study aimed to compare the clinical and radiographic mid-term results between short and conventional stems.
Patients with bilateral osteonecrosis of the femoral head (ONFH) who had undergone bilateral staged THAs using short stem in one hip and conventional stem in the contralateral hip were included. The Harris Hip Score (HHS), thigh pain, patient's joint perception (PJP) and patients' preferred hip were recorded. Using x-ray, osseointegration and stress shielding were analyzed and compared between stems.
There were 35 cases (70 hips) with the mean age of 46.3years (25-63), and the mean follow-up was 75.1months (60-108). HHS was significantly improved in both short and conventional groups (p < 0.001). There was mild thigh pain in 2 cases (5.7%) of the short stem group and 6 cases (17.1%) of the conventional group. With regard to the PJP, we found slightly more natural joint feeling in the short stem group. Of the patients' preferred hip, 11 cases (31.4%) preferred short stem hip and 6 cases (17.1%) preferred conventional stem hip. The short stem group showed osseointegration mainly in the proximal part. The conventional stem group showed osseointegration mainly in the distal part. We found stress shielding grade 1 in 31 cases (88.6%) and grade 2 in 3 cases (8.6%) in the conventional stem group, whereas only grade 1 in 34 cases (97.1%) in the short stem group.
The clinical results were promising in both short and conventional stems; however, short stem showed less thigh pain, slightly more natural joint feeling (PJP) and more patients' preferred hip. The short stem provided more favorable results for proximal load transfer and slightly less stress shielding.
The clinical results were promising in both short and conventional stems; however, short stem showed less thigh pain, slightly more natural joint feeling (PJP) and more patients' preferred hip. The short stem provided more favorable results for proximal load transfer and slightly less stress shielding.Rare earth elements (REE) are becoming an environmental pollutant of emerging concern, linked to their use in various anthropic processes. Because REE bioconcentrate in marine organisms throughout their food webs, a better understanding of biogeochemical processes leading to REE concentrations found in coastal species is necessary. This study was designed to assess REEs concentrations in various common bivalves from the French coastline to identify possible geographic, taxonomic, or temporal variations of concentrations. Based on the French Mussel Watch program, three species of bivalves (oyster Crassostrea gigas and mussels Mytilus edulis and Mytilus galloprovincialis) were collected all along the French metropolitan coast and soft tissues were analyzed for REE concentrations. Results have shown higher REE concentrations in bivalve soft tissues near estuaries without taxonomic nor national geographic differences. The highest levels have been observed in the Gironde estuary with total REE concentrations (∑REE) in oysters up to 10.94 µg g-1 d.w. The REE distribution pattern in both mussel species described a particle-like (inverse V-shape) pattern, whereas C. gigas REE distribution pattern changes from a particle-like to a dissolved-like pattern with a heavy REE (HREE) enrichment. However, no environmental parameter could be linked to these pattern changes. Finally, neither Gd anomalies nor an evolution of REE concentrations over a 30-year period have been detected in bivalves' soft tissues.
Operative management of posterior tibial plateau fractures (PTPF) remains challenging. The treatment goal is to restore the alignment and articular congruence, and providing sufficient stability which allows early mobilization. The purpose of this study was to assess the feasibility and safety of the newly developed WAVE posterior proximal tibia plate.
Between Oct 2017 and Jun 2020, 30 adult patients with a tibial plateau fracture and posterior involvement were selected for treatment with a WAVE posterior proximal tibia plate. Patient reported outcome was assessed using the Knee injury and Osteoarthritis Outcome Score (KOOS) at time of injury (pre-injury) and at 1-year follow-up. Radiological outcome was evaluated with CT-imaging.
Twenty-eight patients were eligible for treatment with the new implant (3 'one-column', 10 'two column' and 15 'three-column' fractures), whereas in 2 patients anatomical fit was insufficient. KOOS results showed fair outcome scores at 1 year, with a large negative impact compared to pre-injury levels; however, a trend towards better results compared to a previous PTPF reference cohort. Radiological follow-up showed insufficient posterolateral buttress in two cases and residual articular step-off (> 2mm) in seven patients, of which five were classified as three column fractures.
Management of PTPF using the WAVE posterior proximal tibia plate is feasible and safe with satisfactory clinical and radiological results after 1 year. Nevertheless, there is a learning curve regarding optimal implant positioning to achieve the maximum benefit of the implant.
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4.Aripiprazole has become one of the most commonly prescribed psychotropics, making a more comprehensive understanding of its reproductive safety profile a priority. The goal of the current analysis was to determine the risk of major malformations in infants exposed during the first trimester of pregnancy to aripiprazole compared to infants whose mothers had psychiatric diagnoses but did not use an atypical antipsychotic during pregnancy. The National Pregnancy Registry for Atypical Antipsychotics is a prospective pharmacovigilance program in which pregnant women are enrolled and interviewed during pregnancy and the postpartum period. Medical records are assessed to confirm presence or absence of major malformations. Pregnant women ages 18-45 with psychiatric diagnoses are enrolled. As of April 2020, N = 848 women who had delivered infants were eligible for analyses. A total of 158 women with first trimester exposure to aripiprazole were compared to 690 controls. For 163 infants born to women in the exposed group, seven major malformations were confirmed (4.29%), compared to fourteen of the 690 unexposed infants (1.99%). The unadjusted odds ratio for major malformations between aripiprazole-exposed and unexposed infants was 2.21 (95% confidence interval [CI] = (0.88, 5.57) The adjusted odds ratio for major malformations was 1.35 (95% confidence interval [CI] = (0.43, 4.20). After adjustment for confounding variables, the risk of major malformations after first trimester exposure to aripiprazole was not significant compared to controls. While these results are reassuring, they are limited by relatively small numbers of participants. Future analyses with larger numbers are expected to provide more of a complete and precise reproductive safety profile regarding aripiprazole use during pregnancy. Trial registration clinicaltrials.gov NCT01246765.
