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The research planning requirements for publicly funded research circumscribe the possibilities for co-production, including impacting on the possibility of stability and continuity over time. © 2020 The Authors Health Expectations published by John Wiley &amp; Sons Ltd.Developing highly efficient and low cost photocatalyst for overall water splitting has long been a pursuit for conversing solar power to clean hydrogen energy. Herein, we demonstrate that nonstoichiometric nickel-cobalt double hydroxide could implement overall water splitting by itself upon sunlight irradiation, avoiding the consumption of noble-metal co-catalyst. We employed an intensive laser to ablate a NiCo alloy target immersed in alkaline solution, and produced so-called L-NiCo nanosheets with nonstoichiometric composition and O 2- /Co 3+ ions exposed on the surface. The nonstoichiometric composition broadens the band gap, while O 2- and Co 3+ ions boost hydrogen and oxygen evolution reactions, respectively. As such, the photocatalyst achieves a H 2 evolution rate of 1.7 μmol h -1 under the AM 1.5G sunlight irradiation and apparent quantum yield (AQE) of 1.38% at 380 nm. © 2020 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.Organocatalysis is a powerful approach to extend and (enantio-) selectively modify molecular structures, as those comprising the prebiotic feedstock. Adapting this concept to the Early Earth scenario offers a promising solution to explain their evolution into a complex homochiral world. In this work, we present a class of imidazolidine-4-thione (photoredox-) organocatalysts, easily accessible from simple molecules available on an Early Earth under highly plausible prebiotic reaction conditions. These imidazolidine-4-thiones are readily formed from mixtures of aldehydes or ketones in presence of ammonia, cyanides and hydrogen sulphide in high selectivity and distinct preference for individual compounds of the resulting catalyst library. These organocatalysts successfully enable the challenging enantioselective α-alkylation of aldehydes under prebiotic conditions and show activities that correlate with the selectivity of their formation. Furthermore, the crystallization of single catalysts as conglomerates opens the pathway for symmetry breaking. © 2020 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.OBJECTIVE TP53 plays a crucial role in preventing cancer development. Previous studies in sub-Saharan Africa (SSA) reported inconclusive findings for the association of the TP53 rs1042522 C&nbsp;&gt;&nbsp;G variant with cervical cancer. We therefore performed a meta-analysis to summarise this association in the SSA population. [https://www.selleckchem.com/products/nibr-ltsi.html NIBR-LTSi] METHODS Online databases were searched to identify suitable articles according to the PRISMA guidelines. We included studies published in English or French that provided the sample sizes and genotype counts for both cases and controls and evaluated the association between TP53 rs1042522 and cervical cancer in the SSA population. A fixed-effect model was used to calculate the pooled odds ratio (OR) and 95% confidence intervals (95% CIs). RESULTS A total of 699 cervical cancer cases and 1008 controls from eight studies in SSA were included in this meta-analysis. Women harbouring the variant G allele of the TP53 rs1042522 were at increased risk of cervical cancer in allelic (G vs. C; OR&nbsp;=&nbsp;1.30, 95% Cl&nbsp;=&nbsp;1.12-1.50), homozygous (GG vs. CC; OR&nbsp;=&nbsp;1.62, 95% CI&nbsp;=&nbsp;1.20-2.19) and recessive (GG vs. CG&nbsp;+&nbsp;GG; OR&nbsp;=&nbsp;1.74, 95% CI&nbsp;=&nbsp;1.34-2.25) genetic models. However, the dominant genetic model (CG&nbsp;+&nbsp;GG vs. CC; OR&nbsp;=&nbsp;1.20, 95% CI&nbsp;=&nbsp;0.96-1.48) was not significantly associated with cervical cancer. CONCLUSIONS Our meta-analysis revealed that harbouring variant G allele of TP53 rs1042522 is associated with cervical cancer risk in the SSA population. © 2020 John Wiley &amp; Sons Ltd.BACKGROUND Historically, tumor burden has been considered an impediment to efficacy of immunotherapeutic agents, including vaccines, stem cell transplant, cytokine therapy, and intravesical bacillus Calmette-Guérin. This effect has been attributed to hypoxic zones in the tumor core contributing to poor T-cell infiltration, formation of immunosuppressive stromal cells, and development of therapy-resistant cell populations. However, the association between tumor burden and efficacy of immune checkpoint inhibitors is unknown. We sought to determine the association between radiographic tumor burden parameters and efficacy of immune checkpoint inhibitors in advanced lung cancer. MATERIALS AND METHODS We performed a retrospective analysis of patients with advanced lung cancer treated with immune checkpoint inhibitors. Demographic, disease, and treatment data were collected. Serial tumor dimensions were recorded according to RECIST version 1.1. Associations between radiographic tumor burden (baseline sum of longest stem cell transplant, and intravesical bacillus Calmette-Guérin. However, in the present study, no association was found between tumor burden and efficacy (response rate, progression-free survival, overall survival) of immune checkpoint inhibitors in advanced lung cancer. These findings suggest that immune checkpoint inhibitors may provide benefit across a range of disease burden, including bulky tumors considered resistant to other categories of immunotherapy. © AlphaMed Press 2020.PURPOSE To evaluate and compare the surface properties (roughness and hardness) of poly(methylmethacrylate) denture base material modified with zirconium dioxide (ZNPs), silicon dioxide (SNPs), and diamond (DNPs) nanoparticles. MATERIALS AND METHODS Two hundred sixty heat-polymerized acrylic resin disks (15 × 2 mm) were prepared. ZNPs, SNPs, and DNPs were added in concentrations of 0%, 0.5%, 1.0%, 2.5%, and 5.0% by weight of acrylic powder. This yielded a total of 13 groups for each test according to filler type and concentration (n = 10/group). The control group was made of pure acrylic. A mechanical polisher was used to standardize specimens' surfaces before testing. A profilometer and Vickers hardness indenter were used to test the surface roughness and hardness, respectively. ANOVA and Tukey post hoc tests were used for data analysis (α = 0.05). RESULTS In comparison to control, results showed a nonsignificant increase in surface roughness (Ra ) of acrylic material after the addition of 0.5% nanoparticles (ZNPs p = 0.