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Nowadays there are numerous studies on the occurrence of cognitive dysfunction in late-life depression (LLD). The role of executive dysfunctions in the psychopathology of depression is particularly emphasized and needs further examination. [https://www.selleckchem.com/products/nvp-tnks656.html NVP-TNKS656 purchase] The aim was to assess cognitive functions and their relation to depressive symptoms in elders with LLD, previously depressed, and patients without the history of depressive episodes. The study consisted of 824 older adults who underwent a neuropsychological evaluation (97 currently depressed, 114 previously depressed and 613 patients without the history of depressive episodes). LLD patients performed poorer in ACE-III and AVLT and poorer in TMT-B than those previously depressed and never depressed. The LLD group also performed significantly poorer than the previously depressed on Digit Span Forward. Results of a multiple regression analysis indicated that performance on measures of executive functioning was associated with depression severity in LLD (β =.227, P =.024). The results of this study suggest that executive functions are the most impaired in the elderly with LLD. Furthermore, there is a relationship between executive dysfunction and the severity of depression in LLD. Executive dysfunction appears to be the core neurocognitive deficit in LLD.Aim We aimed to identify that long noncoding RNAs (lncRNAs) are involved in ischemia-reperfusion (IR)-induced late fibrosis of kidney and may constitute novel therapeutic strategies for acute kidney injury-induced chronic kidney disease. Materials &amp; methods We performed the mouse model of IR later induced renal fibrosis and analyzed lncRNA profiles using second-generation sequencing during the pathogenesis. Results The expression levels of 43 lncRNAs and 141 lncRNAs were respectively changed significantly 7 days and 2 weeks after IR treatment. Based on the correlation analysis of the differentially expressed genes, the interaction networks of lncRNAs, miRNAs and mRNA were structured. Conclusion LncRNA (Gm12840) could act as a sponge for miR-677-5p to mediate fibroblast activation induced by TGF-β1 via the WISP1/PKB (Akt) signaling pathway.<br /><br /> The Chinese healthcare industry has immense potential for innovation and requires competent publication professionals for global reach. Changes in regulatory landscape of China necessitates pharmaceutical industries to collaborate with medical professionals who are capable of keeping up with both changes in regulations and innovative medicine.<br /><br /> We initiated an online questionnaire-based survey <br /><br /> WeChat from August 3 to August 14, 2019 which focused on experience level, challenges, career development, and training requirements of survey participants.<br /><br /> A total of 53 medical publication professionals participated in this survey. Contrary to global trends, 77% of participants had &lt;5 years of professional experience in publication, although only 36% of participants had &lt;5 years of experience in healthcare industry. In all, 63% of respondents spent &lt;50% of their time in publication-related activities, contributing to &lt;10 manuscripts per year. Their expertise in manuscripts spanned clinical studies (68%), post-marketing studies (62%), and reviews (38%). Poor research design and data quality, limited medical writing skill, and inefficient communication with authors were major challenges for developing high-quality publications. Awareness of good publication practices guidelines was high (49%) and 15% of respondents were Certified Medical Publication Professionals. Strategic publication planning (72%), industry trends (66%), and best practices (55%) were some of training requirements identified to increase competencies among respondents.<br /><br /> Although the Chinese medical publication professional industry is at a nascent stage, an attempt is being made to provide opportunities for its publication professionals to develop their competencies to match global standards.<br /><br />Although the Chinese medical publication professional industry is at a nascent stage, an attempt is being made to provide opportunities for its publication professionals to develop their competencies to match global standards.Purpose Consonant repetitions within words are a well-attested speech error pattern in children's early speech acquisition. We investigated the role of intervening vowel context in understanding speech forms containing consonant repetitions in early words. Intrasyllabic consonant-vowel (CV) sequences within consonant-vowel-consonant (CVC) and consonant-vowel-consonant-vowel (CVCV) forms containing consonant repetitions were analyzed to evaluate whether children's lack of independent movement control for the tongue in word-level sequences might contribute to these observed speech patterns. Method Spontaneous speech data produced by 10 typically developing children learning American English were analyzed longitudinally from the onset of word use to 36 months. Overall patterns and word shape effects for nine CV combinations occurring in their CVC and CVCV word shapes that contained repeated nonadjacent consonants and the intervening vowel were analyzed. Results Three CV combinations-coronal-front vowel, labial-central vowel, and dorsal-back vowel-occurred at above-chance levels. Preference for these CV patterns was strong in CVCV but not in CVC word shapes. These CV combinations occurred frequently at all time periods analyzed for CVCV's while decreasing across time for CVC's. Conclusions Analysis of intrasyllabic patterns within word forms containing consonant repetitions revealed that consonant repetitions in many early words occurred at above-chance levels in the context of articulatorily compatible vowels. Results suggest that children's production system capacities are an important contributing principle accounting for vowel context effects within word forms containing consonant repetitions during earliest speech acquisition.<br /><br /> The aim was to examine parents' experiences of engagement in a friendship-making intervention for youth with physical and developmental disabilities.<br /><br /> This mixed methods study used a convergent parallel design where quantitative and qualitative data were collected concurrently, analyzed independently, and then merged into an overall interpretation. Four parents completed the Pediatric Rehabilitation Intervention Measure of Engagement-Parent version at four points during the 8-week program. They also took part in post-intervention interviews about their engagement-related experiences, including their involvement, interest, and confidence in the parent sessions.<br /><br /> Parents' engagement experiences were captured in four themes involving the person-intervention fit the relevance of program content, the usefulness of the content, their behavioral involvement in planning and group discussions, and seeing youth experience success. The themes corroborated the quantitative measurement of engagement and illustrated and elaborated on how program factors influenced engagement.