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Even though ageing processes in bitumen negatively affect its softening capacity, the developed structures still retain the ability to partially compensate for the adverse hardening effects. Furthermore, DSA addition greatly enhances the binder's wettability on a siliceous-type aggregate and favours asphalt compaction.Fusidic acid (FA) is an efficient anti-bacterial drug proven to be efficient against a wide range of bacteria. Nevertheless, the main restriction in its formulation is the limited solubility. To avoid such an obstacle, the drug is incorporated into the lipid core of the nanolipid formulation. Consequently, the present study was an attempt to formulate nanolipid preparation, mainly, solid lipid nanoparticle (SLN) integrating FA. FA-SLN was prepared using shea butter as a lipid phase owing to its reported anti-bacterial activity. Different FA-SLNs were fabricated using the central composite design (CCD) approach. The optimized formula was selected and integrated into a hydrogel base to be efficiently used topically. FA-SLN-hydrogel was evaluated for its character, morphology, in vitro release and stability. [https://www.selleckchem.com/products/pacap-1-38.html see more] The formula was examined for irritation reaction and finally evaluated for its anti-bacterial performance. The optimized formula showed particle size 283.83 nm and entrapment 73.057%. The formulated FA-SLN-hydrogel displayed pH 6.2, viscosity 15,610 cP, spreadability 51.1 mm and in vitro release 64.6% following 180 min. FA-SLN-hydrogel showed good stability for three months at different conditions (room temperature and refrigerator). It exhibited no irritation reaction on the treated rats. Eventually, shea butter displayed a noteworthy effect against bacterial growth that improved the effect of FA. This would indicate prospective anti-bacterial activity of FA when combined with shea butter in SLN formulation as a promising nanocarrier.Biopolymer based scaffolds are commonly considered as suitable materials for medical application. Poly(lactic acid) (PLA) is one of the most popular polymers that has been used as a bioscaffold, but it has poor cell adhesion and slowly degrades in an in vitro environment. In this study, silk fibroin (SF) was selected to improve cell adhesion and degradability of electrospun PLA. In order to fabricate a PLA/SF scaffold that offered both biological and mechanical properties, related parameters such as solution viscosity and SF content were studied. By varying the concentration and molecular weight of PLA, the solution viscosity significantly changed. The effect of solution viscosity on the fiber forming ability and fiber morphology was elucidated. In addition, commercial (l-lactide, d-lactide PLA) and medical grade PLA (pure PLLA) were both investigated. Mechanical properties, thermal properties, biodegradability, wettability, cell viability, and gene expression of electrospun PLA and PLA/SF based nanofibrous scaffolds were examined. The results demonstrated that medical grade PLA electrospun scaffolds offered superior mechanical property, degradability, and cellular induction for meniscus tissue regeneration. However, for commercial non-medical grade PLA used in this study, it was not recommended to be used for medical application because of its toxicity. With the addition of SF in PLA based scaffolds, the in vitro degradability and hydrophilicity were improved. PLAmed50SF50 scaffold has the potential to be used as biomimetic meniscus scaffold for scaffold augmented suture based on mechanical properties, cell viability, gene expression, surface wettability, and in vitro degradation.The natural nacre has a regular ordered layered structure of calcium carbonate tablets and ion crosslinking proteins stacked alternately, showing outstanding mechanical properties. Inspired by nacre, we fabricated different divalent metal cation-crosslinked montmorillonite-alginate hybrid films (MMT-ALG-X2+; X2+ = Cu2+, Cd2+, Ba2+, Ca2+, Ni2+, Co2+ or Mn2+). The effect of ionic crosslinking strength and hydrogen bond interaction on the mechanical properties of the nacre-mimetics was studied. With the cations affinities with ALG being increased (Mn2+ &lt; Co2+ = Ni2+ &lt; Ca2+ &lt; Ba2+ &lt; Cd2+ &lt; Cu2+), the tensile strength of nacre-mimetics showed two opposite influence trends Weak ionic crosslinking (Mn2+, Co2+, Ni2+ and Ca2+) can synergize with hydrogen bonds to greatly increase the tensile properties of the sample; Strong ionic crosslinking (Ba2+, Cd2+, Cu2+) and hydrogen bonding form a competitive relationship, resulting in a rapid decrease in mechanical properties. Mn2+ crosslinking generates optimal strength of 288.0 ± 15.2 MPa with an ultimate strain of 5.35 ± 0.6%, obviously superior to natural nacre (135 MPa and 2%). These excellent mechanical properties arise from the optimum synergy of ion crosslinking and interfacial hydrogen bonds between crosslinked ALG and MMT nanosheets. In addition, these metal ion-crosslinked composite films show different colors, high visible transparency, and excellent UV shielding properties.This study investigates the effects of red mud on the performance of geopolymer concrete in regard to fresh and mechanical properties. Red mud was used as a binder, and GGBS replaced the binder. Different proportions of red mud ranging from 0 to 30% with an interval of 2% and activator agents such as KOH and K2SiO3 for various alkaline-to-binder ratios such as 0.30, 0.40, and 0.50 were used; their effect on the fresh and mechanical properties of geopolymer concrete were the focusing parameter on the current study. Fresh properties such as setting time, slump, compaction factor, and vee-bee consistometer test, and mechanical properties such as compressive strength, split tensile strength, flexural strength, modulus of elasticity, and impact energy were studied. ANOVA and radar plot analysis were studied for various alkaline to binder (A/B) compressive strength results tested for 7 to 90 days. The increase of red mud quantity caused the decline of workability, but there was continuous enhancement of mechanical properties of GPC up to a specific limit. An alkaline-to-binder ratio of 0.4 shows excellent results compared with other ratios at ambient conditions for strength properties. ANOVA and radar plot reveal that A/B of 0.40 for 90 days shows excellent results compared with other ratios, and CS values vary in a linear manner.Membrane separation processes are prevalent in industrial wastewater treatment because they are more effective than conventional methods at addressing global water issues. Consequently, the ideal membranes with high mechanical strength, thermal characteristics, flux, permeability, porosity, and solute removal capacity must be prepared to aid in the separation process for wastewater treatment. Rubber-based membranes have shown the potential for high mechanical properties in water separation processes to date. In addition, the excellent sustainable practice of natural fibers has attracted great attention from industrial players and researchers for the exploitation of polymer composite membranes to improve the balance between the environment and social and economic concerns. The incorporation of natural fiber in thermoplastic elastomer (TPE) as filler and pore former agent enhances the mechanical properties, and high separation efficiency characteristics of membrane composites are discussed. Furthermore, recent advancements in the fabrication technique of porous membranes affected the membrane's structure, and the performance of wastewater treatment applications is reviewed.Polylactides (PLAs) are thermoplastic materials known for their wide range of applications. Moreover, the equimolar mixtures of poly(L-Lactide) (PLLA) and poly(D-Lactide) (PDLA) can form stereocomplexes (SCs), which leads to the formation of new non-covalent complex macromolecular architectures. In this work, we report the synthesis and characterization of non-covalent triblock terpolymers of polystyrene-b-stereocomplex PLA-b-poly(2-vinylpyridine) (PS-b-SC-b-P2VP). Well-defined ω-hydroxy-PS and P2VP were synthesized by "living" anionic polymerization high-vacuum techniques with sec-BuLi as initiator, followed by termination with ethylene oxide. The resulting PS-OH and P2VP-OH were used as macroinitiators for the ring-opening polymerization (ROP) of DLA and LLA with Sn(Oct)2 as a catalyst to afford PS-b-PDLA and P2VP-b-PLLA, respectively. SC formation was achieved by mixing PS-b-PDLA and P2VP-b-PLLA chloroform solutions containing equimolar PLAs segments, followed by precipitation into n-hexane. The molecular characteristics of the resulting block copolymers (BCPs) were determined by 1H NMR, size exclusion chromatography, and Fourier-transform infrared spectroscopy. The formation of PS-b-SC-b-P2VP and the effect of molecular weight variation of PLA blocks on the resulting polymers, were investigated by differential scanning calorimetry, X-ray powder diffraction, and circular dichroism spectroscopies.Wound healing-associated difficulties continue to drive biotechnological creativeness into complex grounds. The sophisticated architecture of skin wound sites and the intricate processes involved in the response to the use of regenerative devices play a critical role in successful skin regeneration approaches and their possible outcomes. Due to a plethora of complications involved in wound healing processes as well as the coordination of various cellular mechanisms, biomimetic approaches seems to be the most promising starting ground. This study evaluates the behavior of a crosslinked, porous collagen scaffold obtained by lyophilization and dehydrothermal reticulation (DHT). We address the key physio-chemical and mechanical factors, such as swelling, density and porosity, mechano-dynamic properties, SEM and TG-DSC, as well as important biological outcomes regarding scaffold biocompatibility and cellular metabolic activity, cytokine expression in inflammation, apoptosis and necrosis, as well as hemocompatibility and biodegradation. The mechanical and visco-elastic behavior are correlated, with the samples found to present similar thermal behavior and increased rigidity after DHT treatment. High biocompatibility rates were obtained, with no inflammatory stimulation and a reduction in necrotic cells. Higher percentages of cellular early apoptosis were observed. The hemocompatibility rate was under 2%, coagulation effects expressed after 4 min, and the DHT scaffold was more resistant to the biodegradation of collagenase compared with the untreated sample.In a circular economy, polymeric materials are used in multiple loops to manufacture products. Therefore, closed-loops are also envisaged for the mechanical recycling of plastics, in which plastic is used for products that are in turn collected and reprocessed again and again to make further products. However, this reprocessing involves degradation processes within the plastics, which become apparent through changes in the property profile of the material. In the present paper, the influence of multiple recycling loops on the material properties of four different polyolefins was analyzed. Two different closed-loop cycles with industrially sized processing machines were defined, and each polyolefin was processed and reprocessed within the predefined cycles. For the investigation of the effect of the respective loops, samples were taken after each loop. The samples were characterized by high-pressure liquid chromatography coupled to a quadru-pole time-of-flight MS, high-temperature gel permeation chromatography, melt flow rate measurements, infrared spectroscopy, differential thermal analysis, and tensile tests.