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Objective Cognitive reserve (CR) refers to the capacity of the brain to actively cope with damage via the implementation of remedial cognitive processes. Traditional CR measurements focus on static proxies, which may not be able to appropriately estimate dynamic changes in CR. This study therefore investigated the cognitive performance and characteristics of brain activity of low- and high-CR healthy adults during resting and n-back task states and categorized subjects according to magnetoencephalographic (MEG) information using a support vector machine (SVM) classifier. Approach Forty-one volunteers were divided into groups with low and high CR indexes based on their education, occupational attainment, leisure and social activities. Main results The results can be summarized as follows First, subjects with a higher CR had higher accuracies and faster reaction times in the task. Second, subjects with a lower CR had a higher M300 intensity but a constant M300 latency. Third, subjects with a higher CR had a higher beta intensity in the parietal and occipital regions during the task, whereas subjects with a higher CR had a higher gamma intensity in the right temporal region in the resting state. Finally, subjects with a higher CR had negative gamma asymmetry between the right and left occipital regions, whereas subjects with a lower CR had positive values in the resting state. Significance These MEG results were subsequently used to classify subjects into high/low-CR subjects using an SVM classifier, and a mean accuracy of 88.89% was obtained. This objective and nonstatic method for determining CR level warrants further research for a wider variety of future clinical applications.Objectives to implement a multi-field-optimization (MFO) technique for treating patients with high-Z implants in pencil beam scanning proton-therapy and generate treatment plans that avoids small implants. Two main issues were addressed i) the assessment of the optimal CT acquisition and segmentation technique to define the dimension of the implant and ii) the distance of pencil beams from the implant (avoidance margin) to assure that it does not affect dose distribution. Methods different CT reconstruction protocols (by O-MAR or standard reconstruction and by 12-bit or 16-bit dynamic range) followed by thresholding segmentation were tested on a phantom with lead spheres of different sizes. The proper avoidance margin was assessed on a dedicated phantoms of different materials (copper/tantalum and lead), shape (square slabs and spheres) and detectors (two-dimensional array chamber and radio-chromic films). The method was then demonstrated on a head-and-neck carcinoma patient, who underwent carotid artery emboe knowledge of its composition.The LNE-LNHB has developed a methodology to standardize electronic brachytherapy sources in terms of absorbed dose to water. It is based on the measurement of the air-kerma rate at a given distance from the source and the Monte Carlo calculation of a conversion factor. This factor converts the air kerma in measurement conditions into absorbed dose to water at reference depth (1 cm) in a water phantom. As a first application, the method was used to calibrate a Zeiss INTRABEAM system equipped with its 4 cm diameter spherical applicator. [https://www.selleckchem.com/products/tubastatin-a.html Tubastatin A] The absorbed-dose rate value obtained in the current study was found significantly higher than that provided by the manufacturer in line with the observations already reported by a few other teams.The recent generalised nonlocal optical response (GNOR) theory for plasmonics is analysed, and its main input parameter, namely the complex hydrodynamic convection-diffusion constant, is quantified in terms of enhanced Landau damping due to diffusive surface scattering of electrons at the surface of the metal. GNOR has been successful in describing plasmon damping effects, in addition to the frequency shifts originating from induced-charge screening, through a phenomenological electron diffusion term implemented into the traditional hydrodynamic Drude model of nonlocal plasmonics. Nevertheless, its microscopic derivation and justification is still missing. Here we discuss how the inclusion of a diffusion-like term in standard hydrodynamics can serve as an efficient vehicle to describe Landau damping without resorting to computationally demanding quantum-mechanical calculations, and establish a direct link between this term and the Feibelman d parameter for the centroid of charge. Our approach provides a recipe to connect the phenomenological fundamental GNOR parameter to a frequency-dependent microscopic surface-response function. We therefore tackle one of the principal limitations of the model, and further elucidate its range of validity and limitations, thus facilitating its proper application in the framework of nonclassical plasmonics.Antibacterial fibers have great potential in many applications including wound dressings, surgical gowns, and surgical sutures, and play an important role in our daily life. However, the traditional fabrication method for the antibacterial fibers shows high cost, complexity, and inferior antibacterial durability. Herein, we report a facile and scalable fabrication of highly effective antibacterial alginate (SA) composite fibers through blend spinning of zeolitic imidazolate framework-67 (ZIF-67) particles and SA. The fabricated ZIF-67@SA composite fibers show high tensile strength and initial modulus. More importantly, the ZIF-67@SA composite fibers demonstrate excellent antibacterial properties, and the antibacterial efficiency reaches over 99% at ultralow ZIF-67 loading (0.05 wt%). In addition, the ZIF-67@SA fibers show good antibacterial durability even after 5 laundering cycles. The excellent antibacterial performance of the ZIF-67@SA fibers are attributed to the synergistic effects of highly effective antibacterial ZIF-67 particles, swelling of alginate, and immobilization of ZIF-67 particles on both inside and outside fiber surface. This work may shed light on the antibacterial mechanism of metal organic frameworks and pave the way for the development of high-performance antibacterial textiles.