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This highlights the importance of considering how stalking recidivism is defined in future works and may explain current differences in stalking recidivism findings.<br /><br /> There are increasing numbers of referrals to ophthalmology departments due to blurred optic disc margins. In light of this and the COVID-19 pandemic we aimed to assess whether these patients could be safely assessed without direct contact between the clinician and patient.<br /><br /> We retrospectively reviewed the records of consecutive patients seen in our 'blurred disc clinic' between August 2018 and October 2019. We then presented anonymous information from their referral letter, their visual fields and optic nerve images to two consultant neuro-ophthalmologists blinded to the outcome of the face-to-face consultation. In the simulated virtual clinic, the two consultants were asked to choose an outcome for each patient from discharge, investigate or bring in for a face-to-face assessment.<br /><br /> Out of 133 patients seen in the blurred disc clinic, six (4.5%) were found to have papilloedema. All six were identified by both neuro-ophthalmologists as needing a face-to-face clinic consultation from the simulated virtual clinic. One hundred and twenty (90%) patients were discharged from the face-to-face clinic at the first consultation. The two neuro-ophthalmologists chose to discharge 114 (95%) and 99 (83%) of these respectively from the simulated virtual clinic. [https://www.selleckchem.com/products/cb-5339.html CB-5339 chemical structure] The virtual clinic would have potentially missed serious pathology in only one patient who had normal optic discs but reported diplopia at the previous face-to-face consultation.<br /><br /> A virtual clinic model is an effective way of screening for papilloedema in patients referred to the eye clinic with suspicious optic discs. Unrelated or incidental pathology may be missed in a virtual clinic.<br /><br />A virtual clinic model is an effective way of screening for papilloedema in patients referred to the eye clinic with suspicious optic discs. Unrelated or incidental pathology may be missed in a virtual clinic.The role of routine activity theory (RAT) as a guiding theoretical approach to understand online victimization has been well documented. However, the recent emphasis in criminology on its applicability to online victimization has largely been based on evidence from Anglo-American studies. This study fills this gap by testing the predictive utility of RAT for cyberstalking victimization, using data from a sample of female Iranian students. Our structural equation model showed that online exposure to motivated offenders, target suitability, and ineffective online guardianship were positively and significantly associated with cyberstalking victimization. Our results provide strong support for RAT, indicating its generalizability to a different sociopolitical context.<br /><br /> Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancer entities, which is characterized by abundant desmoplastic stroma. The stroma consists of extracellular matrix, infiltrating immune cells, cancer-associated fibroblasts (CAFs) and others. Depending on environmental cues, CAFs can be highly heterogeneous and play context-dependent roles in PDAC progression.<br /><br /> In this article, we discuss the biological significance of CAFs heterogeneity (oncogenic vs. tumor-suppressive) in pancreatic carcinogenesis. In particular, the complex interaction between CAFs and infiltrating immune cells has a determinant role in defining the stromal composition. A subset of PDAC patients may benefit from anti-CAFs therapy.<br /><br /> Co-defined by CAFs and infiltrating immune cells, the prognostic stroma signature is clinically relevant in a subset of human PDAC. This is the patient population which may benefit from future anti-stroma or anti-CAFs therapies. To consider CAF heterogeneity is crucial for designing anti- of CAFs to immunosuppressive microenvironment of PDAC, it is conceivable to combine anti-CAFs therapy with immunotherapy. To implement a CAF-subtype specific therapy is crucially important to improve the effectiveness of current treatments including chemotherapies and immunotherapy.The social environment within individual sport teams can have a significant influence on the success, development, and well-being of athletes. We explored elite individual sport athletes' group experiences through the lens of social identity theorising. Participants were six members (4 male, 2 female, Mage = 21.5 years) of a National Development Nordic Ski team. At two time points in the competitive season, we used Social Identity Mapping (Bentley et al., 2020) in combination with semi-structured interviews to explore athletes' experiences as a member of the ski team. Social Identity Mapping provided a visual representation of each participant's social identities and was used to facilitate athletes' views of their group experiences in the semi-structured interviews. Interview data were thematically analysed to explicate participants' perceptions of social identity and cohesion, and their perceived relevance to success and development in elite individual sport. Major themes included social group memberships and identities, the presence of subgroups, the ebb and flow of cohesion and conflict, and teammate and coach influence on the group. On this basis, we argue that social identity mapping can be a valuable resource for athletes and coaches seeking to create a positive and cohesive team environment within an elite individual sport team.<br /><br /> To understand the impact of face coverings on hearing and communication.<br /><br /> An online survey consisting of closed-set and open-ended questions distributed within the UK to gain insights into experiences of interactions involving face coverings, and of the impact of face coverings on communication.<br /><br /> Four hundred and sixty members of the general public were recruited via snowball sampling. People with hearing loss were intentionally oversampled to more thoroughly assess the effect of face coverings in this group.<br /><br /> With few exceptions, participants reported that face coverings negatively impacted hearing, understanding, engagement, and feelings of connection with the speaker. Impacts were greatest when communicating in medical situations. People with hearing loss were significantly more impacted than those without hearing loss. Face coverings impacted communication content, interpersonal connectedness, and willingness to engage in conversation; they increased anxiety and stress, and made communication fatiguing, frustrating and embarrassing - both as a speaker wearing a face covering, and when listening to someone else who is wearing one.