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At 5years, the median marginal bone level was located at -0.15mm (IQR -0.89mm; 0.27mm) (CEM) and -0.26mm (IQR -0.38mm; 0.01mm) (SCREW) below the implant shoulder (intergroup p=.9598). The median changes between baseline and the 5-year follow-up amounted to -0.23mm (CEM; intragroup p=.0002) and -0.15mm (SCREW; intragroup p=.1465) (intergroup p=.1690). The overall technical complication rate at 5years was 15.4% (CEM) and 15.4% (SCREW) (intergroup p=1.00). Clinical parameters remained stable over time (baseline to 5years).<br /><br /> At 5years, screw-retained and cemented restorations rendered largely the same clinical, technical, and radiographic outcomes. Technical complications were frequent in both groups.<br /><br />At 5 years, screw-retained and cemented restorations rendered largely the same clinical, technical, and radiographic outcomes. Technical complications were frequent in both groups.<br /><br /> Recurrence is the major cause of hepatocellular carcinoma (HCC) death. We aimed to identify circular RNA (circRNA) with predictive and therapeutic value for recurrent HCC.<br /><br /> Tissue samples from recurrent and non-recurrent HCC patients were subjected to circRNA sequencing and transcriptome sequencing. circKCNN2 was identified through multi-omics analyses. The effects of circKCNN2 on HCC were evaluated in cells, animals, database of The Cancer Genome Atlas, and a cohort with 130 HCC patients. circRNA precipitation, chromatin immunoprecipitation assay, RNA pull-down, luciferase assay, and cell experiments were applied to evaluate the interaction of circKCNN2 with miRNAs and proteins. The association between circKCNN2 and the therapeutic effect of lenvatinib was investigated in HCC cell lines and HCC tissue-derived organoids.<br /><br /> The expression of circKCNN2 was downregulated in HCC tissues and predicted a favorable overall survival and recurrence-free survival. The expression of circKCNN2 was positively correlateatinib. However, the high inherent level of circKCNN2 in HCC cells was associated with lenvatinib resistance.<br /><br /> circKCNN2, transcriptionally repressed by NFYA, suppresses HCC recurrence via the miR-520c-3p/MBD2 axis. Inherent level of circKCNN2 in HCC cells predisposes anti-tumor effect of lenvatinib possibly because both circKCNN2 and lenvatinib repress the expression of FGFR4. circKCNN2 may be a promising predictive biomarker and therapeutic agent for HCC recurrence.<br /><br />circKCNN2, transcriptionally repressed by NFYA, suppresses HCC recurrence via the miR-520c-3p/MBD2 axis. Inherent level of circKCNN2 in HCC cells predisposes anti-tumor effect of lenvatinib possibly because both circKCNN2 and lenvatinib repress the expression of FGFR4. circKCNN2 may be a promising predictive biomarker and therapeutic agent for HCC recurrence.<br /><br /> Neurotropic virus infection can cause serious damage to the central nervous system (CNS) in both humans and animals. The complexity of the CNS poses unique challenges to investigate the infection of these viruses in the brain using traditional techniques.<br /><br /> In this study, we explore the use of fluorescence micro-optical sectioning tomography (fMOST) and single-cell RNA sequencing (scRNA-seq) to map the spatial and cellular distribution of a representative neurotropic virus, rabies virus (RABV), in the whole brain. Mice were inoculated with a lethal dose of a recombinant RABV encoding enhanced green fluorescent protein (EGFP) under different infection routes, and a three-dimensional (3D) view of RABV distribution in the whole mouse brain was obtained using fMOST. Meanwhile, we pinpointed the cellular distribution of RABV by utilizing scRNA-seq.<br /><br /> Our fMOST data provided the 3D view of a neurotropic virus in the whole mouse brain, which indicated that the spatial distribution of RABV in the brain was influenced by the infection route. Interestingly, we provided evidence that RABV could infect multiple nuclei related to fear independent of different infection routes. More surprisingly, our scRNA-seq data revealed that besides neurons RABV could infect macrophages and the infiltrating macrophages played at least three different antiviral roles during RABV infection.<br /><br /> This study draws a comprehensively spatial and cellular map of typical neurotropic virus infection in the mouse brain, providing a novel and insightful strategy to investigate the pathogenesis of RABV and other neurotropic viruses.<br /><br />This study draws a comprehensively spatial and cellular map of typical neurotropic virus infection in the mouse brain, providing a novel and insightful strategy to investigate the pathogenesis of RABV and other neurotropic viruses.Non-selective beta-blockers (NSBBs) are the cornerstone of the primary and secondary prophylaxis of variceal bleeding in cirrhotic patients. They additionally prevent ascites development and death in compensated patients with clinically significant portal hypertension. After ascites onset, NSBBs remain beneficial for preventing further decompensations. However, as the cirrhosis progresses, the inflammation increases, systemic vasodilatation worsens, ascites turns refractory and cardiodynamic equilibrium becomes extremely fragile. In this scenario, NSBBs can critically impair the cardiac reserve and facilitate a haemodynamic breakdown, imperilling renal perfusion. Consequently, NSBB treatment should be carefully monitored or even avoided in such patients, and other options for portal hypertension management should be considered. In the present review, we explore the effects of NSBBs in patients with ascites and discuss the complex interplay among their hepatic, systemic and renal haemodynamic effects in this scenario.Seasonal variations in gut microbiota of small mammals and how they are influenced by environmental variables are relatively poorly understood. We sampled 162 wild plateau pikas (Ochotona curzoniae) in 4 seasons over 2 and a half years and recorded the air temperature, precipitation, and nutrient content in edible vegetation at the sampling site. After conducting 16S rRNA and shotgun metagenomic sequencing, we found that the highest alpha diversity, the relative abundance of Firmicutes, and the simplest co-occurrence network occurred in winter, whereas the highest relative abundance of Proteobacteria and the most complex network structure were observed in spring. The highest relative abundance of Verrucomicrobiota and Spirochaetota was seen in summer and autumn, respectively. Air temperature, precipitation, and the contents of crude protein, crude fiber, and polysaccharide in vegetation had significant effects on the seasonal changes in gut microbiota. Diet contributed more to microbial variation than climatic factors. Metagenomic analysis revealed that the amino acid metabolism pathway and axillary activity enzymes were most abundant in summer, while abundance of carbohydrate-binding modules and carbohydrate esterases was highest in spring. These microbial variations were related to the changes in dietary nutrition, indicating that gut microbiota of plateau pika contribute to the efficient use of food resources. This study provides new evidence of how external environmental factors affect the intestinal environment of small mammals.A Rh2 O3 /BiVO4 composite photoanode exhibits enhanced surface reaction kinetics and charge transfer efficiency, enabling a photocurrent density of ca. 3.5 mA/cm2 at 1.23 V (vs. RHE), which is about 3.89 times higher than that of the pristine BiVO4 , with a lower onset potential of 0.29 V (vs. RHE).<br /><br /> COVID-19 has profoundly affected dental undergraduate teaching and assessment. The pandemic resulted in cessation of face-to face teaching and assessment in many countries, with an associated move online. Objective structured Clinical Examination (OSCE), an important modality for clinical assessment in dentistry and medicine, is not possible with pandemic restrictions in place. As a result, interest in virtual objective structured clinical examination (VOSCE) has been revived. Student and staff evaluation of any assessment process is important, where the views of all involved are required in establishment of authenticity. This papers aims to explore and describe the views of undergraduate dental students and staff in relation to VOSCE MATERIALS AND METHOD Qualitative methods utilising online focus groups and video recording were used in this study. Five focus groups, involving 24 participants were undertaken.<br /><br /> Thematic analysis following a deductive semantic approach was carried out resulting in the identification of six themes relating to the VOSCE VOSCE preconceptions, examination preparation, examination process, fairness, comparison with OSCE and possible improvements. [https://www.selleckchem.com/products/bai1.html learn more] Consideration of these themes, and their interaction, is likely to prove important for optimisation of this assessment modality.<br /><br /> Overall, both staff and students considered the VOSCE a useful and fair examination and a suitable alternative to OSCE. The potential for a number of improvements in the assessment process was identified.<br /><br />Overall, both staff and students considered the VOSCE a useful and fair examination and a suitable alternative to OSCE. The potential for a number of improvements in the assessment process was identified.Adverse event reporting systems are important tools for identifying areas of risk and opportunities quality improvement. Perioperative airway management (PAM) carries patient risk. We examine the nature of PAM incident reports at an academic tertiary care center. In this retrospective data review, perioperative safety reports filed under "Airway Management" between 2015 and 2020 were analyzed. Data analyzed included severity level (patient harm) and specific event type. There was a total of 7827 safety reports filed from January 2015 to July 2020, with 67 reports related to "Airway Management" (0.85%). The most common specific event type in this safety reporting database was "Intubation Injury (Mouth, Tooth, Airway)" (35.8%). The most common severity level of all reported events was level 2 (temporary or minor harm, 57%). Our safety reporting data demonstrates that adverse events related to PAM are likely to reach the patient and can cause significant harm. Data from our findings can help providers and risk managers to focus efforts on reducing patient harm. Strategies include continued education in technical skills and crisis management, preparation for the difficult airway, increased availability of video laryngoscopes, ongoing safety reporting and collaborative review of adverse events with implementation of quality improvement measures.<br /><br /> Prenatal care is a fundamental moment for health promotion to be carried out, since at that moment women are more receptive to new knowledge, with the aim of providing better healthcare for the baby. This study aimed to evaluate the knowledge, attitudes and practices of undergraduate students and professionals, both from the public and from private sectors in Brazil, regarding dental prenatal care.<br /><br /> This study corresponded to an online questionnaire survey, via Google Forms, consisting of 17general questions for undergraduates (n=103) and 16 for professionals (n=227) for demographic and school mapping, and 18specific questions about the importance and protocol of dental prenatal care. T-test, Mann-Whitney U-test and multiple linear regression were adopted (p&lt;.05).<br /><br /> The average total score of the questionnaire for students and professionals was 12.40 and 15.65, respectively (p&lt;.0001), indicating moderate knowledge. Professionals showed a higher prevalence of moderate (77%) and high (2%) knowledge of the subject when compared to undergraduate students (51% and 0% respectively).