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The molecular docking and molecular dynamic simulation results of HSF1/Sch A suggested that Sch A formed key hydrogen bond and hydrophobic interactions with HSF1, which may contribute to its potent HSF1 inhibition. These findings provide clues for the design of novel HSF1 inhibitors and drug candidates for colon cancer treatment. © 2020 The Author(s).The article presents the effects of manoeuvring a wheelchair with manual pushrim propulsion on the position of the centre of gravity of the human body during wheelchair movement. Twenty seven propulsion tests for wheelchairs moving at different trajectories were carried out as part of the study. The trajectories were 10 to 15 m long and reflected moving forward, reversing, turning left and right. A change in position of the centre of gravity of the human body was determined in each test. The trajectory of the centre of gravity of the human body was determined based on the wheelchair trajectory. The trajectories of the wheelchair and the centre of gravity were superimposed to show the effects of the movement caused by manoeuvring the wheelchair on changes in position of the centre of gravity of the human body in relation to the symmetry plane of the wheelchair. The tests showed the effects of wheelchair trajectory on position of the centre of gravity of the human body. As a result, a trajectory deviation factor, reflecting the shift of the human body weight to one side of the wheelchair. Copyright (c) 2020 by ASME.BACKGROUND Laser skin resurfacing with erbium-doped yttrium aluminum garnet (ErYAG) lasers is a newer alternative to CO2 laser treatment, and was developed to reduce common complications. Although ErYAG lasers have been available for years, safety parameters for efficacious resurfacing with these devices have not previously been available. [https://www.selleckchem.com/products/gsk2879552-2hcl.html GSK-2879552 LSD1 inhibitor] OBJECTIVES The aim of this study was to utilize one practice's laser treatment settings and outcomes data to identify complication rates for various energies and areas of the face and to offer safe energy/depth parameters for treating each area. METHODS A retrospective chart review was performed for full-field confluent laser resurfacing patients treated with a Sciton Contour Tunable Resurfacing ErYAG laser by the senior author. The data were retroactively analyzed with a time range of 8 years (January 2007-December 2015). RESULTS The overall complication rate for MicroLaserPeels (ablation of 50 µm or less) was 10.1% (20 of 198 treatments) and the rate for deep resurfacing treatments was 26.5% (71 of 268 cases). In MicroLaserPeel treatments the cheek area had the highest complication rate, followed by the forehead, nose, perioral, and eyelid areas, in that order (complication rate range, 0%-9.1%). In deep resurfacing treatments the perioral area had the highest complication rate, 38.6% of 145 cases. This was followed by the lids, cheek, nose, and forehead, in that order (complication rate range, 15.2%-20.9%). There is a correlation between increased depth of ablation and increased rate of complication. CONCLUSIONS The study confirmed the efficacy of ErYAG resurfacing and provides guidance for a safer approach to excellent outcomes. LEVEL OF EVIDENCE 4 © 2020 The Aesthetic Society. Reprints and permission journals.permissions@oup.com.Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted low-molecular weight iron-siderophore binding protein. NGAL overexpression in injured tubular epithelia partly explain its utility as a sensitive and early urinary biomarker of acute kidney injury (AKI). Herein, we extend mechanistic insights into the source and kinetics of urinary NGAL excretion in experimental AKI. Three models of experimental AKI were undertaken in adult male Wistar rats; renal ischemia-reperfusion injury (IRI) and gentamicin (G) and cisplatin (Cisp) nephrotoxicity. Alongside standard histological and biochemical assessment of AKI, urinary NGAL excretion rate, plasma NGAL concentration and renal NGAL mRNA/protein expression were assessed. In situ renal perfusion studies were undertaken to discriminate direct shedding of NGAL to the urine from addition of NGAL to the urine secondary to alterations in the tubular handling of glomerular filtrate derived protein. Renal NGAL expression and urinary excretion increased in experimental AKI. In acute studies in both the IRI and G models, direct renal perfusion with Kreb's buffer eliminated urinary NGAL excretion. Addition of exogenous NGAL to the Kreb's buffer circuit, reestablishment of perfusion with systemic blood or reperfusion with renal vein effluent restored high levels of urinary NGAL excretion. Urinary NGAL excretion in AKI arises in large proportion from reduced reabsorption from the glomerular filtrate. Hence, sub-clinical cellular dysfunction could increase urinary NGAL, particularly in concert with elevations in circulating pre-renal NGAL and/or pharmacological inhibition of tubular reabsorption. More granular interpretation of urinary NGAL measurements could optimise the scope of its clinical utility as a biomarker of AKI. © The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email journals.permissions@oup.com.Traumatic brain injury (TBI) is often associated with microstructural tissue damage in the brain, which results from its complex biomechanical behavior. Recent studies have shown that the deep white matter (WM) region of the human brain is susceptible to being damaged due to strain localization in that region. Motivated by these studies, in this paper we propose a geometrically nonlinear dynamical reduced order model (ROM) to model and study the dynamics of the deep WM region of the human brain under coronal excitation. In this model, the brain hemispheres were modeled as lumped masses connected via viscoelastic links, resembling the geometry of the corpus callosum (CC). Employing system identification techniques, we determined the unknown parameters of the ROM, and ensured the validity of the ROM by comparing its response against the response of an advanced finite element (FE) model. Next, utilizing modal analysis techniques, we determined the energy distribution among the governing modes of vibration of the ROM and concluded that the demonstrated nonlinear behavior of the FE model might be predominantly due to the special geometry of the brain deep WM region.