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Albumin in tears had a significant impact on pupillary diameter for both tropicamide (P ≤ 0.001) and latanoprost (P ≤ 0.047), with no differences noted between 0.4% and 1.5% concentrations. Reduction in the maximal effect (pupil size) and overall drug exposure (area under the effect time-curve of pupil size over time) were significant for tropicamide (6.2-8.5% on average, P ≤ 0.006) but not for latanoprost (P ≥ 0.663). The IOP, only measured in eyes receiving latanoprost, was not significantly impacted by the addition of either 0.4% (P = 0.242) or 1.5% albumin (P = 0.879). Albumin in tear film, previously shown to leak from the conjunctival vasculature in diseased eyes, may bind to topically administered drugs and reduces their intraocular penetration and bioavailability. Further investigations in clinical patients and other commonly used ophthalmic medications are warranted. Copyright © 2020 Sebbag, Moody and Mochel.Background and Objective Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer's disease (AD) and may represent a more advanced preclinical status than amnestic mild cognitive impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure and their correlation with cognitive function in these AD-spectrum patients. Methods Diffusion tensor images from 43 individuals with normal cognition (NC), 38 SCD patients, and 36 aMCI patients were compared using an atlas-based segmentation strategy. The correlation between diffusion parameters and cognitive function was further analyzed. Results The anatomical pattern of WM impairment was generally similar between SCD and aMCI patients. However, aMCI patients showed significantly lower fractional anisotropy (i.e., corpus callosum forceps major and forceps minor) and increased mean diffusivity [i.e., bilateral anterior thalamic radiation (ATR), left corticospinal tract (CST), forceps minor, left cingulum (cingulate gyrus), left cingulum hippocampus, and left inferior fronto-occipital fasciculus (IFO)] in some tracts than did SCD subjects, indicating a disruption in WM microstructural integrity in the aMCI. Individuals with microstructural disruption in forceps minor, left cingulum (cingulate gyrus), and left cingulum hippocampus tracts performed worse in general cognition and memory function tests, as indicated by line regression analysis. [https://www.selleckchem.com/products/diphenhydramine.html Selleck Diphenhydramine] Conclusion SCD individuals had extensive WM microstructural damage in a pattern similar to that seen in aMCI, although presenting a cognitive performance comparable with that of cognitively healthy individuals. Our results suggest that WM integrity might precede objectively measurable memory decline and may be a potential early biomarker for AD. Copyright © 2020 Luo, Li, Qin, Chen, Yang, Huang, Liu, Xu, Bai and Zhao.Aging coincides with a decline in navigation and wayfinding abilities, but it is unclear to what extent factors relating to a given individual may contribute to mitigating this decline. The present study aims to analyze how older adults' objective cognitive functioning and self-reported subjective wayfinding inclinations predict their navigation performance. Sixty-four older adults were assessed on their general cognitive functioning (all scoring from 22 to 30 on the Montreal Cognitive Assessment, MoCA), visuospatial working memory (VSWM), and perspective-taking abilities. Their self-assessed wayfinding inclinations (such as their sense of direction, pleasure in exploring places, and spatial anxiety) were also examined. Then participants learned a path in an environment from video navigation and performed a route repetition task (which maintained the same egocentric perspective as the learning phase), and a sketch map task (which involved switching from an egocentric perspective used in the learning phase to an allocentric perspective). The results showed that positive wayfinding inclinations (in terms of pleasure in exploring) related to participants' route repetition accuracy, while their general cognitive performance (MoCA scores) related to their sketch map drawing accuracy. Individual factors such as cognitive functioning and wayfinding inclinations relate differently to older people's navigation performance, depending on the demands of the tasks used to test their environment learning. Copyright © 2020 Muffato and De Beni.Functional neuroimaging studies have emphasized distinct networks for social cognition and affective aspects of empathy. However, studies have not considered whether substrates of social cognition, such as the right temporoparietal junction (TPJ), play a role in affective responses to complex empathy-related stimuli. Here, we used repetitive transcranial magnetic stimulation (TMS) to test whether the right TPJ contributes to psychophysiological responses to another person's emotional suffering. We used a theory of mind functional localizer and image-guided TMS to target the sub-region of the right TPJ implicated in social cognition, and measured autonomic and subjective responses to an empathy induction video. We found evidence that TMS applied at 1 Hz over the right TPJ increased withdrawal of parasympathetic nervous system activity during the empathy induction (n = 32), but did not affect sympathetic nervous system activity (n = 27). Participants who received TMS over the right TPJ also reported feeling more irritation and annoyance, and were less likely to report feeling compassion over and above empathic sadness, than participants who received TMS over the vertex (N = 34). This study provides preliminary evidence for the role of right TPJ functioning in empathy-related psychophysiological and affective responding, potentially blurring the distinction between neural regions specific to social cognition vs. affective aspects of empathy. Copyright © 2020 Miller, Xia and Hastings.The electrophysiology of the paralimbic network ("default mode") for self-awareness has drawn much attention in the past couple of decades. In contrast, knowledge of the molecular organization of conscious experience has only lately come into focus. We here review newer data on dopaminergic control of awareness in humans, particularly in self-awareness. These results implicate mainly dopaminergic neurotransmission and the control of GABAergic function directly in the paralimbic network. The findings are important for understanding addiction, developmental disorders, and dysfunctional consciousness. Copyright © 2020 Lou, Rømer Thomsen and Changeux.