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Suzuki Indomobil Motor Plant (SIMP) Cakung, East Jakarta, Indonesia generates wastewater containing heavy metals such as nickel, zinc, chromium, copper, and COD derived from the metal coating process using the electroplating system. Electroplating wastewater produced by this company contains Nickel and COD above the quality standards set by the Government of DKI Jakarta (Governor Regulation No. 69/2013). This research aims to analyze and compare the efficiency and kinetics of Nickel complexes and COD removal using the Advanced Oxidation Process (AOP) and Electrocoagulation (EC) method. Electroplating wastewater generated by SIMP Cakung (ratio of plating wastewater to overflow plating wastewater is 130) in this study had characteristics of 379-568 ppm (effluent standard = 75 ppm) of COD, and 87.555-121 ppm (effluent standard = 1 ppm) of Nickel. Preliminary experiments with the factorial design method indicated that independent variables (pH, current density, ozone flow rate, and contact time) had a critical inindustrial wastewater, but also it could reduce the loading of COD for further treatment units by more than 50%. Further studies in the effect of the longer contact time and higher ozone flowrate on COD removal is suggested. © 2020 The Author(s).Culture is a fundamental element of intercultural relationships and contributes to its effectiveness. This methodological study' s purpose is to test the Turkish version of the Intercultural Effectiveness Scale. The scale is a reliable and valid. It is important to include intercultural communication competence in nursing curriculum programs to ensure that students gain all these awareness, skills and behaviors. © 2020 The Author(s).With the introduction of population-based bowel cancer screening, rectal cancer is diagnosed at earlier stages, yet standard treatment still requires the same extensive surgery that is used for more advanced stages. Organ preserving treatment is rapidly developing and is subject of investigation in numerous clinical trials. The STAR-TREC trial is an international, multi-centre randomised trial investigating organ preservation using (chemo)radiotherapy. Patients with small mrT1-3bN0V0M0 tumours are randomized between three arms standard TME, organ preservation with SCRT or with CRT. In this trial, the clinical target volume has been tailored to the early staged disease of the included patients. This mesorectal irradiation volume includes the mesorectum and pre-sacral lymph nodes at the level of the tumour, two centimetres below and cranially up to the S2-3 interspace level. In contrast to conventional irradiation volumes, the lateral lymph nodes and the nodes along the superior rectal artery are excluded. As a result, the dose to the bowel, bladder, anal sphincter and the neurovascular plexus in the lower pelvis is substantially decreased, especially when combined with modern irradiation techniques, such as dynamic arc therapy. These lower doses are expected to lead to decreasing acute and late toxicity and beneficial functional outcomes. The implementation of this novel target volume will be accompanied by an extensive quality assurance program in the STAR-TREC trial. We describe the rationale behind the novel, mesorectal only radiotherapy treatment used in the STAR-TREC trial specifically tailored for early stage disease, with the goal of organ preservation. © 2020 The Author(s).Cerium oxide nanoparticles have been shown to sensitize cancer cells to radiation damage. Their unique redox properties confer excellent therapeutic potential by augmenting radiation dose with reactive oxygen species mediating bystander effects. Owing to its metallic properties, cerium oxide nanoparticles can be visualized inside cells using reflected light and optical sectioning. This can be advantageous in settings requiring none or minimal sample preparation and modification. We investigated the use of reflectance imaging for the detection of unmodified nanoceria in MDA MB231 breast cancer cells along with differential interference contrast imaging and fluorescent nuclear labeling. We also performed studies to evaluate the uptake capability, cellular toxicity and redox properties of nanocaria in these cells. Our results demonstrate that reflectance structured illumination imaging can effectively localize cerium oxide nanoparticles in breast cancer cells, and when combining with differential interference contrast and fluorescent cell label imaging, effective compartmental localization of the nanoparticles can be achieved. The total number of cells taking up the nanoparticles and the amount of nanoparticle uptake increased significantly in proportion to the dose, with no adverse effects on cell survival. Moreover, significant reduction in reactive oxygen species was also observed in proportion to increasing nanoceria concentrations attesting to its ability to modulate oxidative stress. In conclusion, this work serves as a pre-clinical scientific evaluation of the effective use of reflectance structured illumination imaging of cerium oxide nanoparticles in breast cancer cells and the safe use of these nanoparticles in MDA MB231&nbsp;cells for further therapeutic applications. © 2020 The Authors.Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated. [https://www.selleckchem.com/products/npd4928.html NPD4928] It is well known that abnormal glycosylation is involved in oncogenesis, and fucosylation is one of the most important types of glycosylation. In particular, fucosyltransferase 8 (FUT8) is the only FUT responsible for α1, 6-linked fucosylation (core fucosylation), and it is involved in various physiological as well as pathophysiological processes, including cancer biology. Therefore, we aimed to identify the expression of FUT8 in endometrial endometrioid carcinoma and investigate the effect of the partial silencing of the FUT8 gene on the cell proliferation of Ishikawa cells, an epithelial-like endometrial cancer cell line. Quantitative real-time PCR analysis showed that FUT8 gene expression was significantly elevated in the endometrial endometrioid carcinoma, compared to the normal endometrium.