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5-fold) in comparison with the control. The prophylactic co-immunization significantly decreased the breast tumors' volume (78%) and increased the tumor-bearing mice survival time (37.5%) in comparison with the control. Taking together, prophylactic co-immunization with these multiepitope DNA and peptide cancer vaccines can activate the immune system against breast cancer. However, further experiments are needed to evaluate their efficacy from different angles.The Official World Golf Ranking (OWGR) offers a rich data source that may be used by golf National Sporting Organisations (NSOs) to inform the allocation of human and financial capital. Golf has undergone many changes over the past few decades, thus before rankings data can be used for benchmarking purposes it is crucial to appraise its temporal stability. This study aimed to determine whether the ranking pathways of top 100 golfers have changed over time. Data were collected on 470 golfers who entered the top 100 between January 1990 and December 2018. Golfers were assigned to birth-year defined cohorts Cohort 1 (1989-1999) (n = 79); Cohort 2 (1979-1988) (n = 153); Cohort 3 (1969-1978) (n = 174); and Cohort 4 (1959-1986) (n = 64). Descriptive statistics were reported for ranking milestones and one-way ANOVAs used to investigate temporal trends. Golfers from younger age cohorts reached milestones at significantly earlier ages and in less time than their older peers. For instance, the time taken to reach the OWGR top 100 for Cohort 1, 2, 3, and 4 was 3.55, 5.99, 7.72, and 10.23 years, respectively. Together, these findings highlight the temporal instability of golf rankings data and provide scientific data to inform athlete selection and investment decisions.ObjectiveThe Singapore myResponder is a novel smartphone application developed by the Singapore Civil Defence Force (SCDF) that notifies volunteer first responders of a suspected out-of-hospital cardiac arrest (OHCA) case and locations of Automated External Defibrillators (AED) in the vicinity so that they can assist with resuscitation. We aimed to examine the performance of this application, challenges encountered, and future directions.MethodsWe analyzed data from the myResponder app since its launch from April 2015 to July 2019. The number of installations, registered community first responders, suspected OHCA cases, notifications sent by the app, percentage of responders who accepted activation and arrived at scene were reviewed. A subgroup of taxi driving responders (within a 1.5-kilometer response radius) carrying an AED under a subsequent pilot program was also analyzed.ResultsBy July 2019, 46,689 responders were registered in the myResponder app. There were a total of 19,189 cases created for suspected OHCA, with a median of 358 cases per month (IQR 330-430), in which 10,073 responders accepted activation from myResponder and 4,955 arrived on-scene. A total of 135,599 notifications were sent for these cases, with a median of 7.1 notifications per case (IQR 4.3-8.7). In 2019, the percentages of responders who accepted notification and arrived on scene were 45.8% and 24.1%, respectively. 43% (1110/2581) of responders arrived before EMS crew.ConclusionThe myResponder mobile application is a feasible smart technology solution to improve community response to OHCA, and to increase bystander CPR and AED use. Future directions include increasing the number of active responders, improving response rates, app performance, and better data capture for quality improvement.Aquatain® is an alternative larvicide formulation to the currently used larvicides. Its efficacy can be assessed monitoring emerging adults with a floating device that was recently developed for use in catch basins. In this study, the efficacy of Aquatain in controlling Aedes albopictus and Culex pipiens complex was investigated by comparing the adults emerging from 25 treated catch basins with that of 25 control basins in northeastern Italy. Basins were monitored weekly for 9 times and the efficacy was evaluated using the Mann-Whitney U-test and calculating the inhibition of emergence at each sampling. Aquatain was effective in reducing the number of emerging mosquitoes for both species, but its duration was affected by rainfall. Intensive showers (&gt;10 mm daily) seem to reduce the efficacy of the product, allowing an increase in emerging adults after about 2 wk. This finding suggests that climatic factors should be taken into account to decide the right time for reapplication of Aquatain during routine larval treatments.Collections of mosquitoes were conducted for the surveillance of species of medical importance in the state of Morelos, Mexico, in June 2017. Species collected included Mansonia (Mansonia) dyari, which was identified using morphological characters and cytochrome c oxidase I DNA barcoding. Although 3 species of genus Mansonia have been previously reported in Mexico, this is the 1st confirmed record of Ma. dyari in Morelos State, where no Mansonia species had been recorded. Historical records of Ma. dyari and Ma. indubitans in Mexico were reviewed. Therefore, this record increases the number of mosquito species occurring in Morelos to 46. The specimens collected in this study were deposited in the Culicidae collection of the Universidad Autónoma Agraria Antonio Narro, Unidad Laguna.The efficacy of CocoBear™ Larvicidal Oil and Aquatain® AMF Liquid Mosquito Film against larval and pupal Culex quinquefasciatus was compared (at maximum label field application rates) when applied to concrete troughs treated with composted cow manure. At 1 h posttreatment, CocoBear provided significantly greater reduction of mosquito larvae than Aquatain, but both products were equally effective in producing &gt;97% control at 24 h. Each product provided &gt;98% pupal reduction at 1 h posttreatment, with complete elimination of pupae from troughs at 24 h. CocoBear and Aquatain proved to be equally effective against Cx. quinquefasciatus immatures in organically enriched aquatic habitats.Standard residual pesticides applied to US military materials such as camouflage netting can reduce mosquito biting pressure in the field but may contribute to the evolution of resistance. However, residual applications of a spatial repellent such as transfluthrin could allow mosquitoes the opportunity to escape, only inducing mortality if insects linger, for example after becoming trapped in a treated tent. In this study we investigated the capability of transfluthrin on 2 types of US military material to reduce natural populations of disease vector mosquitoes in a cool-arid desert field environment in southern California. [https://www.selleckchem.com/products/terephthalic-acid.html Terephthalic cell line] We found that transfluthrin could reduce Culex tarsalis incursion into protected areas by up to 100% upon initial treatment and up to 45% for at least 16 days posttreatment, showing that this compound could be an effective element in the US Department of Defense integrated vector management system appropriate for further study.