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The risk of adverse event occurrence was significantly higher for endoscopists with experience of  20 G-POEM procedures is significantly associated with decreased incidence of AEs.BACKGROUND Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) is a procedure that has had encouraging results for peritoneal metastases (PM) from diverse tumour origins, but it is not exempt from high morbidity. Recently, the important role of laparoscopy in oncologic surgeries and its benefits have been evaluated for CRS + HIPEC in selected patients, which has yielded promising results. The aim of our study is to analyse the use of laparoscopy for CRS + HIPEC in patients with limited peritoneal disease. METHODS We have conducted a retrospective study from a prospective database in our tertiary referral hospital within the period of January 2009 to July 2019, which includes 825 patients who had PM from varying tumour origins. We have compared the patients treated with the laparoscopic approach (L-CRS-HIPEC) to a matched population who have undergone the open approach (O-CRS-HIPEC) and fulfil the same selection criteria. We have analysed the postoperative outcomes and survival r Further investigation is required to confirm the benefits of minimally invasive procedures for the management of PM.Older adults with Hodgkin lymphoma (HL), commonly defined as age ≥ 60&nbsp;years, represent approximately 20% of the total HL population. Historically, they have significantly inferior outcomes compared with younger patients. The cause of this is multifactorial, including biologic differences (e.g., mixed cellularity and EBV-related disease); high incidence of advanced stage disease; and frequency of comorbidities and decreased organ reserve leading to poorer tolerability of therapy with increased toxicity, including treatment-related mortality. Pretreatment evaluation for older HL patients should entail a geriatric assessment (GA), with evaluation of functional status and comorbidities (e.g., geriatric cumulative illness rating scale, CIRS-G) to determine fitness. Furthermore, treatment selection should be based in part on GA, with fit older patients receiving curative chemotherapy-based regimens and unfit or frail patients considering less intensive or non-chemotherapy-based platforms. Additionally, there may be for unfit or frail patients. In this review, we examine the epidemiology, importance of GA, and current treatment options for older HL patients.BACKGROUND While prognostic information is considered important for treatment decision-making, physicians struggle to communicate prognosis to advanced cancer patients. This systematic review aimed to offer up-to-date, evidence-based guidance on prognostic communication in palliative oncology. METHODS PubMed and PsycInfo were searched until September 2019 for literature on the association between prognostic disclosure (strategies) and patient outcomes in palliative cancer care, and its moderators. Methodological quality was reported. RESULTS Eighteen studies were included. Concerning prognostic disclosure, results revealed a positive association with patients' prognostic awareness. Findings showed no or positive associations between prognostic disclosure and the physician-patient relationship or the discussion of care preferences. Evidence for an association with the documentation of care preferences or physical outcomes was lacking. Findings on the emotional consequences of prognostic disclosure were multifag over time and treatment decision-making, and focus on individualising care.PURPOSE OF REVIEW Studies have revealed a relation between birth weight (BW) and later risk of cardiovascular diseases (CVDs). This meta-analysis aimed to report the dose-response relationship between BW and risk of CVDs. RECENT FINDINGS The relation of BW to CVD subtypes was found to be U-shaped as BW below ~ 2500&nbsp;g and above ~ 4000&nbsp;g affected positively CVD risk (OR = 1.14 = 95%CI 1.03-1.27 and OR = 1.08; 95%CI 0.99-1.18, respectively). Regarding CVD subtypes, low BW was directly linked to greater risk of CHD (OR = 1.15; 95%CI 1.02-1.29) and stroke (OR = 1.28; 95% CI 1.05-1.55), while high BW was related to increased risk of arterial fibrillation in adulthood. A U-shaped nonlinear relationship was specifically demonstrated between BW and overall CVD and its subtypes. There is a U-shaped association between BW and all CVD subtypes.Continuous monitoring of water quality in dam reservoirs is a typically difficult and costly operation. In this study, the results of computer modeling with the CE-QUAL-W2 model were combined with data mining techniques to develop a new method called "delta-normal stress" for identifying the critical temporal and spatial monitoring ranges. For this purpose, long-term variations of three quality parameters including nitrite-nitrate level, dissolved oxygen (DO) level, and water temperature near the outlet of the dam, which is the point of interest for reservoir exploitation, were analyzed. [https://www.selleckchem.com/products/a-1331852.html A-1331852 research buy] Based on this analysis, the time intervals and depth ranges with the highest frequency of significant variations in terms of each parameter were identified. The results showed that given the difference between the delta-normal stress trend of temperature and that of other parameters in Karkheh Dam Reservoir, temperature can be monitored at much lower sampling resolutions and using cheaper methods and equipment without sacrificing accuracy. Based on the frequency of occurrence of delta-normal stress of more than 20% above the total average, the key sampling times and locations for nitrite-nitrate and DO levels were determined to be the periods of January-February, February-March, and March-April, and depths of 60, 55, 50, and 5&nbsp;m, respectively.Though many advancements in personalized medicine have been made, better methods are still needed to predict treatment benefit for patients with colorectal cancer. Patient-derived cancer organoids (PDCOs) are a major advance towards true personalization of treatment strategies. A growing body of literature is demonstrating the feasibility of PDCOs as an accurate and high-throughput preclinical tool for patient treatment selection. Many studies demonstrate that these cultures are readily generated and represent the tumors they were derived from phenotypically and based on their mutation profile. This includes maintenance of the driver muatations giving the cancer cells a selective growth advantage, and also heterogeneity, including molecular and metabolic heterogeneity. Additionally, PDCOs are now being utilized to develop patient biospecimen repositories, perform high to moderate-throughput drug screening, and to potentially predict treatment response for individual patients that are undergoing anti-cancer treatments.